Anti‐inflammatory effects of low‐intensity extremely high‐frequency electromagnetic radiation: Frequency and power dependence

Gapeyev, A. B.; Mikhailik, E.N.; Chemeris, N. K.

doi:10.1002/bem.20381

Cited by 43 publications

(37 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At fixed intensity of 0.1 mW/cm 2 and exposure duration of 20 min, the antiinflammatory effect expressed frequency dependence. The most effective of the examined frequencies were 37.5, 42.2, 51.8, and 65 GHz; while some other ''therapeutic'' frequencies, for example, 53.57 and 61.22 GHz, accepted for so-called EHF-therapy, were less effective or not effective at all with respect to the studied inflammatory process [Gapeyev et al, 2008]. Detailed study of the effect dependence on frequency in a narrow range from 42.0 to 43.0 GHz (with a step of 200 MHz) has shown quasi-resonance character of the effect with the Q-factor of about 70.…”

Section: Introductionmentioning

confidence: 87%

“…To test the ability of low-intensity EHF EMR to induce anti-inflammatory effects, we used a technique of zymosan-induced paw edema previously described in Gapeyev et al [2006Gapeyev et al [ , 2008. Briefly, 25 ml of zymosan suspension (5 mg/ml) was subcutaneously injected into the plantar surface of the left hind paw of mice under light ether anesthesia.…”

Section: Model Of Acute Inflammationmentioning

confidence: 99%

See 1 more Smart Citation

Features of anti‐inflammatory effects of modulated extremely high‐frequency electromagnetic radiation

Gapeyev¹,

Mikhailik²,

Chemeris³

2009

Bioelectromagnetics

View full text Add to dashboard Cite

Using a model of acute zymosan-induced paw edema in NMRI mice, we test the hypothesis that anti-inflammatory effects of extremely high-frequency electromagnetic radiation (EHF EMR) can be essentially modified by application of pulse modulation with certain frequencies. It has been revealed that a single exposure of animals to continuous EHF EMR for 20 min reduced the exudative edema of inflamed paw on average by 19% at intensities of 0.1-0.7 mW/cm(2) and frequencies from the range of 42.2-42.6 GHz. At fixed effective carrier frequency of 42.2 GHz, the anti-inflammatory effect of EHF EMR did not depend on modulation frequencies, that is, application of different modulation frequencies from the range of 0.03-100 Hz did not lead to considerable changes in the effect level. On the contrary, at "ineffective" carrier frequencies of 43.0 and 61.22 GHz, the use of modulation frequencies of 0.07-0.1 and 20-30 Hz has allowed us to restore the effect up to a maximal level. The results obtained show the critical dependence of anti-inflammatory action of low-intensity EHF EMR on carrier and modulation frequencies. Within the framework of this study, the possibility of changing the level of expected biological effect of modulated EMR by a special selection of combination of carrier and modulation frequencies is confirmed.

show abstract

Section: Introductionmentioning

confidence: 87%

Section: Model Of Acute Inflammationmentioning

confidence: 99%

Features of anti‐inflammatory effects of modulated extremely high‐frequency electromagnetic radiation

Gapeyev¹,

Mikhailik²,

Chemeris³

2009

Bioelectromagnetics

View full text Add to dashboard Cite

show abstract

“…The specific absorption rate on the surface of skin of the animals back was calculated by the formula [20] …”

Section: Methodsmentioning

confidence: 99%

Effect on Tumoral Cells of Low Intensity Electromagnetic Waves

Kalantaryan¹,

Martirosyan²,

Nersesyan³

et al. 2011

PIER Letters

View full text Add to dashboard Cite

Abstract-Violations of the process of methylation reveal itself at the early stages of malignant transformation of cells, and the content of 5-methylcytosine can serve as a diagnostic test for tumor formation and treatment of disease. The carried out studies revealed the correlation of antitumor activity of MM-therapy (the use of coherent millimeter electromagnetic waves of low intensity for therapy) with inhibition of methylation of tumor DNA in vivo. It is revealed in our experiments that an half-hour exposure of MM-radiation results in the tumor growth inhibition by 33.5% and a sharp suppression of the level of DNA-methylation 2.5 times. The results obtained in this experiment indicate the prospects of working out the MM-therapy for clinical oncology in the treatment of malignant neoplasms.

show abstract

“…We have shown that the exposure of animals with local and systemic inflammation to EHF EMR with certain physical parameters induced pronounced anti-inflammatory effects [6,7]. The anti-inflammatory effects of EHF EMR were accompanied with significant decrease in DNA damage of peripheral blood leukocytes and neutrophils [8].…”

Section: Introductionmentioning

confidence: 96%

Hydrogen peroxide induced by modulated electromagnetic radiation protects the cells from DNA damage

Gapeyev¹,

Lukyanova²,

Gudkov³

2014

Open Life Sciences

View full text Add to dashboard Cite

It is believed that non-ionizing electromagnetic radiation (EMR) and low-level hydrogen peroxide (H2O2) may change nonspecific resistance and modify DNA damage caused by ionizing radiation. To check this assumption, the combined effects of extremely high-frequency EMR (EHF EMR) and X-rays on induction of DNA damage in mouse whole blood leukocytes were studied. The cells were exposed to X-rays with or without preliminary treatment with EHF EMR or low-level H2O2. With the use of enhanced chemiluminescence, it was shown for the first time that pulse-modulated EHF EMR (42.2 GHz, incident power density of 0.1 mW/cm2, exposure duration of 20 min, modulation frequency of 1 Hz) induced H2O2 at a concentration of 4.6 ± 0.3 nM L−1 in physiological saline. With the use of an alkaline comet assay, it was found that the exposure of cells to the pulse-modulated EHF EMR, 25 min prior to treatment with X-rays at a dose of 4 Gy reduced the level of ionizing radiation-induced DNA damage. Continuous EHF EMR was inefficient. In turn, it was shown that low-level H2O2 (30–500 nM L−1) protected the cells against X-irradiation. Thus, the mechanisms of radiation protective effect of EHF EMR are connected with the induction of the adaptive response by nanomolar concentrations of reactive oxygen species formed by pulse-modulated EHF EMR.

show abstract

Anti‐inflammatory effects of low‐intensity extremely high‐frequency electromagnetic radiation: Frequency and power dependence

Cited by 43 publications

References 37 publications

Features of anti‐inflammatory effects of modulated extremely high‐frequency electromagnetic radiation

Features of anti‐inflammatory effects of modulated extremely high‐frequency electromagnetic radiation

Effect on Tumoral Cells of Low Intensity Electromagnetic Waves

Hydrogen peroxide induced by modulated electromagnetic radiation protects the cells from DNA damage

Contact Info

Product

Resources

About