Anti-inflammatory effects of methanol extract of Antrodia cinnamomea mycelia both in vitro and in vivo

Wen, Chi-Luan; Chang, Chia-Chuan; Huang, Shyh-Shyun; Kuo, Chao‐Lin; Hsu, Shih-Lan; Deng, Jeng-Shyan; Huang, Guan‐Jhong

doi:10.1016/j.jep.2011.06.009

Cited by 53 publications

(35 citation statements)

References 20 publications

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“…The extraction components of AC inhibited LPS-induced expression or production of cytokines, iNOS, COX-2, IL-6, and NO by reducing NF-κB signaling in murine macrophage cells 34–37 . The components of AC also alleviated the carrageenan-induced inflammation response, NO, and TNF-α production and ameliorated imiquimod-induced skin inflammation in vivo 38, 39 . However, the molecular mechanisms of the anti-inflammatory activity of the crude water extract of AC, which is obtained by the clinical traditional method, remain unclear.…”

Section: Introductionmentioning

confidence: 95%

CCM111, the water extract of Antrodia cinnamomea, regulates immune-related activity through STAT3 and NF-κB pathways

Lin

Pan

Lai

et al. 2017

Sci Rep

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Antrodia cinnamomea (AC) exhibits many bioactivities, including anti-inflammatory, anti-cancer, and hepatoprotection activities. Many researchers have studied the functions of the components or fractions of AC, but the functions of the original extractions of AC have not been studied. In addition, the detailed relationship between AC and immune-related signaling pathways is unclear. In this study, we screened the effects of CCM111, which is the extract of AC, on seven immune-related signaling pathways and further investigated whether CCM111 can influence inflammation. Interestingly, our results showed that CCM111 significantly inhibited the IL-6-stimulated STAT3 pathway and the LPS-stimulated NF-κB pathway in macrophages. CCM111 also decreased the phosphorylation of STAT3, Tyk2 and the nuclear translocation of p65. Moreover, CCM111 and F4, a fraction of CCM111, down-regulated nitric oxide (NO) production, the protein levels of iNOS and COX-2, and inflammatory cytokines in macrophage cells. Therefore, our study suggested that CCM111 has the potential to be developed as an effective anti-inflammatory agent.

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Section: Introductionmentioning

confidence: 95%

CCM111, the water extract of Antrodia cinnamomea, regulates immune-related activity through STAT3 and NF-κB pathways

Lin

Pan

Lai

et al. 2017

Sci Rep

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“…Numerous investigations have suggested that several mushroom species can exhibit antiinflammatory potential based on their ability to reduce the production of inflammatory mediators (Kim et al, 2003;Padilha et al, 2009;Wen et al, 2011;Elsayed, Hesham, Mohammad, & Aziz, 2014Taofiq et al, 2015. Their crude extracts (Table 1) have been described to display activity, and attention is now being focused on efforts to discover bioactive compounds capable to suppress the production of inflammatory mediators through gene expression downregulation of different types of inflammatory mediators (Kim et al, 2006, Fangkrathok, Junlatat, & Sripanidkulchai, 2013.…”

Section: The Anti-inflammatory Potential Of Mushroom Extractsmentioning

confidence: 99%

“…Their crude extracts (Table 1) have been described to display activity, and attention is now being focused on efforts to discover bioactive compounds capable to suppress the production of inflammatory mediators through gene expression downregulation of different types of inflammatory mediators (Kim et al, 2006, Fangkrathok, Junlatat, & Sripanidkulchai, 2013. Previous research studies have been carried out on several mushroom species, mainly in methanolic (Kim et al, 2003;Wen et al, 2011;Moro et al, 2012) and ethanolic Kim et al, 2006;Ruthes et al, 2013b;Taofiq et al, 2015) extracts. Most studies have shown that these extracts display antiinflammatory activity, but it is also crucial to identify the metabolites responsible for this bioactivity.…”

Section: The Anti-inflammatory Potential Of Mushroom Extractsmentioning

confidence: 99%

Anti-inflammatory potential of mushroom extracts and isolated metabolites

Taofiq

Martins

Barreiro

et al. 2016

Trends in Food Science & Technology

108

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Background: In the recent years natural resources are being in focus due to their great potential to be exploited in the discovery/development of novel bioactive compounds and, among them, mushrooms can be highlighted as alternative sources of anti-inflammatory agents. Scope and approach:The present review reports the anti-inflammatory activity of mushroom extracts and of their bioactive metabolites involved in this bioactive action.Additionally the most common assays used to evaluate mushrooms anti-inflammatory activity were also reviewed, including in vitro studies in cell lines, as well as in animal models in vivo. Key findings and conclusions:The anti-inflammatory compounds identified in mushrooms include polysaccharides, terpenes, phenolic acids, steroids, fatty acids and other metabolites.Among them, polysaccharides, terpenoids and phenolic compounds seem to be the most important contributors to the anti-inflammatory activity of mushrooms as demonstrated by numerous studies. However, clinical trials need to be conducted in order to confirm the effectiveness of some of these mushroom compounds namely, inhibitors of NF-κB pathway and of cyclooxygenase related with the expression of many inflammatory mediators.

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“…A. cinnamomea is expensive because of several characteristics, such as high medicinal value, scarcity in nature, and difficulty in artificial cultivation. The fruiting body and mycelium extracts of A. cinnamomea have been used as a medicine to improve the activity of organisms in studies involving cell lines and animal models in vivo and in vitro; A. cinnamomea extracts provide anti-oxidative [2], anticancer, anti-hepatitic [3], and anti-inflammatory properties [4]. Previous studies showed that the main active ingredients of A. cinnamomea are antroquinonol [5], succinic acid, maleic acid [6], benzenoids [7], triterpenoids [8], and polysaccharides [9].…”

Section: Introductionmentioning

confidence: 99%

Molecular cloning and expression analysis of mevalonate pyrophosphate decarboxylase inAntrodia cinnamomea

Lin

Shao

et al. 2016

MATEC Web of Conferences

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Abstract. Mevalonate pyrophosphate decarboxylase (MVD) plays important roles in triterpenoid biosynthesis via the mevalonate pathway. A novel MVD gene was isolated and identified in Antrodia cinnamomea (Ac-mvd). The fulllength cDNA contained an open reading frame with a length of 1,209 bp and encoded a 402-amino acid polypeptide with a molecular mass of 43.3 kDa and a theoretical pI of 8.23. As incubation time was prolonged for 28 days, the triterpenoid content in the mycelium gradually increased and reached 39.192 ± 2.025 mg/g; the triterpenoid content of the fruiting body grew in the hay of Cinnamomum kanehirae (ACFB-CK), was 49.391 ± 2.675 mg/g, which was significantly different from other samples (P < 0.05). qRT-PCR revealed that the highest expression levels of Ac-mvd in the mycelium of Antrodia cinnamomea were detected on the 7th day. The expression levels gradually decreased as culture time was extended from 14 days to 42 days.

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Anti-inflammatory effects of methanol extract of Antrodia cinnamomea mycelia both in vitro and in vivo

Cited by 53 publications

References 20 publications

CCM111, the water extract of Antrodia cinnamomea, regulates immune-related activity through STAT3 and NF-κB pathways

CCM111, the water extract of Antrodia cinnamomea, regulates immune-related activity through STAT3 and NF-κB pathways

Anti-inflammatory potential of mushroom extracts and isolated metabolites

Molecular cloning and expression analysis of mevalonate pyrophosphate decarboxylase inAntrodia cinnamomea

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