Anti-inflammatory potential of mushroom extracts and isolated metabolites

Taofiq, Oludemi; Martins, Anabela; Barreiro, María Filomena; Ferreira, Isabel C.F.R.

doi:10.1016/j.tifs.2016.02.005

Cited by 108 publications

(81 citation statements)

References 182 publications

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“…Therefore, the ethanolic extract studied in the present work can be further exploited as a tyrosinase inhibitor to reduce the severity of hyperpigmentation and decrease melanin biosynthesis, partly due to the registered amount on phenolic acids. Regarding the antiinflammatory activity, aqueous, methanolic and ethanolic extracts of G. lucidum presented activity mainly by inhibiting NO, PGE2, TNF-a IL1-b production (Taofiq et al, 2016c). In the present study, ethanolic extract of G. lucidum revealed anti-inflammatory activity by inhibiting NO production.…”

Section: G Lucidum Ethanolic Extracts As Relevant Bioactive Extractssupporting

confidence: 56%

“…In the present study, ethanolic extract of G. lucidum revealed anti-inflammatory activity by inhibiting NO production. Even though the phenolic compounds of mushrooms have been identified as the most important contributors to their anti-inflammatory activity (Taofiq et al, 2015), triterpenic acids such as ganoderic acid C1 and lanostane in G. lucidum, have also contributed significantly to its antiinflammatory activity (Taofiq et al, 2016c).…”

Section: G Lucidum Ethanolic Extracts As Relevant Bioactive Extractsmentioning

confidence: 99%

“…The use of G. lucidum bioactive extracts in the design of cosmeceutical formulations for topical application is receiving special attention. It is supported by existing reports on their power as tyrosinase inhibitors, inflammatory mediator suppressors and as photoprotective agents, which makes them multifunctional ingredients that can be used to control hyperpigmentation, suppressing skin inflammatory diseases and preventing skin photoaging (Taofiq et al, 2016a(Taofiq et al, , 2016cWu et al, 2016). Because of the above mentioned interesting properties, several mushroom extracts and their bioactive components are either presently used or patented to be used as cosmetics ingredients .…”

Section: Introductionmentioning

confidence: 95%

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The potential of Ganoderma lucidum extracts as bioactive ingredients in topical formulations, beyond its nutritional benefits

Taofiq

Heleno

Calhelha

et al. 2017

Food and Chemical Toxicology

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a b s t r a c tGanoderma lucidum was characterized in terms of nutritional value and chemical composition. Thereafter, ethanolic Soxhlet extracts were evaluated for antioxidant, anti-inflammatory, antityrosinase, antimicrobial and cytotoxic effects, and further characterized in terms of phenolic acids, polysaccharides and triterpenoids. Finally, the obtained extracts were tested as cosmeceutical ingredients. G. lucidum proved to be a source of macronutrients and important bioactive compounds such as terpenoids, specially triterpenoids, and polysaccharides. In the extracts, ganoderic acids C2, A and H were the most abundant triterpenic acids and protocatechuic, p-hydroxibenzoic and syringic acids the identified phenolics. The developed cosmeceutical formulation preserved the extract bioactivities, presented a lightyellow colour and a pH of 4.6, which is considered appropriate for cosmeceutical's design. Behind the important nutritional/bioactive composition of G. lucidum, a potential towards its valorisation in the field of cosmeceuticals is foreseeable, as deduced from the bioactivities of its ethanolic extract and preservation in the tested formulation.

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Section: G Lucidum Ethanolic Extracts As Relevant Bioactive Extractssupporting

confidence: 56%

Section: G Lucidum Ethanolic Extracts As Relevant Bioactive Extractsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

See 1 more Smart Citation

The potential of Ganoderma lucidum extracts as bioactive ingredients in topical formulations, beyond its nutritional benefits

Taofiq

Heleno

Calhelha

et al. 2017

Food and Chemical Toxicology

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“…phenolic compounds, terpenoids, polysaccharides, lectins, steroids, glycoproteins and several lipid components. Several mushroom extracts, as well as their secondary metabolites, have been reported to display important biological functions such as antioxidant, antitumor, antimicrobial, anti-inflammatory, immunomodulator, antiatherogenic, and hypoglycemic activities (Ferreira et al, 2009(Ferreira et al, , 2010Alves et al, 2012;Taofiq et al, 2016). On the contrary, only very few studies have been reported for the antityrosinase, anti-collagenase, anti-elastase and anti-hyaluronidase activities of mushroom extracts and individual compounds (References cited in Tables 1 and 2, respectively).…”

Section: Mushroom Extracts and Individual Compounds As Cosmetic Ingrementioning

confidence: 99%

Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics—A review

Taofiq

González-Paramás

Martins

et al. 2016

Industrial Crops and Products

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114

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a b s t r a c tThe cosmetic industry is constantly in search of ingredients from natural sources because of their competitive effectiveness and lower toxicity effects. Mushrooms have been an important part of our diet for years and are now finding their way as cosmetic ingredients, either as cosmeceutical or as nutricosmetics. The present review focuses on the most relevant activities of mushroom extracts, as well as on their bioactive compounds, which make them interesting ingredients for cosmetic formulations. Mushroom extracts, as well as their bioactive metabolites, revealed anti-tyrosinase, anti-hyaluronidase, anti-collagenase and anti-elastase activity. Emphasis was also given to their important anti-oxidant, antimicrobial and antiinflammatory potential, topics largely studied by numerous authors, making them very versatile and multi-functional cosmetic ingredients. Some of the bioactive compounds and the mechanism responsible for the activities ascribed to mushrooms were highlighted. Other activities were identified as needing to be further studied in order to identify the major compounds contributing to the target activity, as well as their mechanisms of action. Based on the above findings, mushroom extracts, as well as their bioactive metabolites, constitute important ingredients that can help to combat aging, reduce the severity of inflammatory skin disease and correct hyperpigmentation disorders. These findings and claims must be correctly supported by clinical trials and in vivo studies.

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“…The most famous member of Tricholoma genus is T. matsutake, on which scientist have focused because of its medicinal properties and commercial potential. The various phytochemicals were isolated form the T. matsutake exhibiting anti-inflammatory, antioxidant and anticancer activities (Ding and Hou, 2012;Taofiq et al, 2016;You et al, 2013). Besides this species other Tricholoma species have been also attracted (Chen et al, 2017;Hassan et al, 2015;Sadi et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Fatty Acid Composition and Antioxidant Activity of Tricholoma Imbricatum and T. Focale

Kaplaner

Singeç

Öztürk

2017

Turkish JAF Sci.Tech.

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Edible mushrooms are one of the important food source because of their tastes, and having high concentration of fatty acids and the other nutrients. In this study, fatty acid composition and antioxidant properties of Tricholoma imbricatum and T. focale were determined. The fatty acids were analysed by GC, and GC-MS while the antioxidant activity was tested using five complimentary methods; namely, β-carotene-linoleic acid, DPPH scavenging, ABTS scavenging, CUPRAC and metal chelating assays. Eight fatty acids were determined in hexane extract, and oleic acid was the major fatty acid with 46.4% and 35.0%, respectively. Palmitic acid (12.8%, and 5.12%) and lineloic acid (28.2% and 31.0%) were also detected in high amounts. In DPPH . scavenging and ABTS ·+ scavenging assays, the methanol extract of T. imbricatum (IC 50 : 0.12±0.01 mg/mL for both assay) showed better antioxidant activity than those of T. focale (IC 50 >0.8±0.01, and IC 50 : 0.21±0.01 mg/mL). All extracts of T. focale exhibited good activity in β-carotenelinoleic acid assay while only the hexane extract of T. imbricatum showed activity. Both mushroom indicated moderate in cupric reducing power. Since the mushrooms are nontoxic and edible, both can be used in food industry as preservatives.

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Anti-inflammatory potential of mushroom extracts and isolated metabolites

Cited by 108 publications

References 182 publications

The potential of Ganoderma lucidum extracts as bioactive ingredients in topical formulations, beyond its nutritional benefits

The potential of Ganoderma lucidum extracts as bioactive ingredients in topical formulations, beyond its nutritional benefits

Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics—A review

Fatty Acid Composition and Antioxidant Activity of Tricholoma Imbricatum and T. Focale

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