2012
DOI: 10.1016/j.intimp.2012.08.021
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Anti-inflammatory effects of phlorofucofuroeckol B-rich ethyl acetate fraction obtained from Myagropsis myagroides on lipopolysaccharide-stimulated RAW 264.7 cells and mouse edema

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Cited by 23 publications
(21 citation statements)
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“…28,29 Yet very little is known about the anti-obesity effects of E. bicyclis and the underlying mechanisms. In this study we investigated potential anti-obesity effects of five purified phlorotannins isolated from E. bicyclis.…”
Section: Discussionmentioning
confidence: 99%
“…28,29 Yet very little is known about the anti-obesity effects of E. bicyclis and the underlying mechanisms. In this study we investigated potential anti-obesity effects of five purified phlorotannins isolated from E. bicyclis.…”
Section: Discussionmentioning
confidence: 99%
“…As anti-inflammatory activities from M. myagroides , fucoxanthin [32], fatty acid [33], 6,6-bieckol [22], and phlorofucofuroeckol B [21] have shown potent activities in macrophage or microglial cells. However, anti-inflammatory activity of MME in this study may not be due to fucoxanthin, fatty acid or phlorotannins, since the peaks of those compounds were not detected in the chromatogram (Figure  6) [20,21]. Thus, we hypothesized strong anti-inflammatory compounds are contained in MME and we separated the components from MME using C 18 column and isolated sargachromenol having strong anti-inflammatory activity (Table  1).…”
Section: Discussionmentioning
confidence: 99%
“…Activation of NF-κB caused by LPS or pro-inflammatory cytokines leads to degradation of IκB-α and inducing translocation of NF-κB into nucleus [12]. Recently, we demonstrated that extract of brown algae including Saccharina japonica [19,20], M. myagroides [21,22], Ecklonia stolonifera [15], and Sargassum fulvellum [39] inhibited the activation of NF-κB signaling pathway through the blockade of proteolytic degradation of IκB-α. In this study, we observed that enhanced phosphorylation of IκB-α by LPS was reduced by MME treatment, suggesting that MME protected the proteolytic degradation of IκB-α (Figure  4B).…”
Section: Discussionmentioning
confidence: 99%
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“…fucoxanthin, fucosterol, phlorotannin (Kim et al, 2010b;Kim et al, 2013a;Lee et al, 2013;Jung et al, 2014). (Joung et al, 2012a;Joung et al, 2012b;Gwon et al, 2013;Kim et al, 2013b), phlorotannin, sargachromenol sargaquinoic acid (Kang et al, 2013;Kim et al, 2014 , 20 µL 5% nonidet NP-40 5 .…”
Section: Nf-b Inhibitor Of Kappa B (I B)mentioning
confidence: 99%