Anti-Inflammatory Effects of Resveratrol in Patients with Ulcerative Colitis: A Randomized, Double-Blind, Placebo-controlled Pilot Study

Samsamikor, Maryam; Daryani, Naser Ebrahimi; Asl, Parisa Rezanejad; Hekmatdoost, Azita

doi:10.1016/j.arcmed.2015.05.005

Cited by 167 publications

(120 citation statements)

References 17 publications

Supporting

Mentioning

114

Contrasting

Unclassified

Order By: Relevance

“…Many previous reports have indicated [36][37][38] that resveratrol can inhibit the inflammationrelated p38MAPK and NF-κB pathways to inhibit the production of inflammatory cytokines, such as COX-2, IL-6, and IL-8, and thereby inhibit the inflammatory cascade response. As a new anti-inflammatory agent, resveratrol has been used extensively in the treatment of many diseases, such as osteoarthritis [39], acute pancreatitis [40], colitis [41], esophagitis [41], acute gouty arthritis [42] and airway inflammation [43]. In the present study, various doses of resveratrol were given to a rat model of postoperative abdominal adhesions, and we found that resveratrol had a significant effect on adhesion prevention.…”

Section: Discussionmentioning

confidence: 53%

Effect of Resveratrol on the Prevention of Intra-Abdominal Adhesion Formation in a Rat Model

Wei

Chen

Wang

et al. 2016

Cell Physiol Biochem

View full text Add to dashboard Cite

Background: Intra-abdominal adhesions are a very common complication following abdominal surgery. Our previous studies have demonstrated that the inhibition of inflammation at the sites of peritoneal injury can prevent the formation of intra-abdominal adhesions. Resveratrol is a natural extract with a broad range of anti-inflammatory effects. Therefore, we propose that resveratrol can reduce the formation of intra-abdominal adhesions after surgery. The aim of this study was to investigate the effect of resveratrol on intra-abdominal adhesion prevention in a rat model with surgery-induced peritoneal adhesions. Materials and Methods: The cecum wall and its opposite parietal peritoneum were abraded following laparotomy to induce intra-abdominal adhesion formation. Varying doses of resveratrol were administered to the animals. On the eighth day after surgery, the adhesion score was assessed using a visual scoring system. Picrosirius red staining and a hydroxyproline assay were used to assess the amount of collagen deposition in the adhesion tissues. The levels of serum interleukin-6 (IL-6), tumor necrosis factor (TNF-α), and transforming growth factor beta-1 (TGF-β1) were determined by an enzyme-linked immunosorbent assay (ELISA). Western blotting was performed to determine the protein expression of TGF-β1, fibrinogen, and α-smooth muscle actin (α-SMA) in rat peritoneal adhesion tissue. Real-time RT-PCR was performed to quantify the mRNA expression of TGF-β1, fibrinogen, and α-SMA. Results: Resveratrol significantly reduced intra-abdominal adhesion formation and fibrin deposition in the rat model. Furthermore, resveratrol significantly reduced the serum levels of IL-6, TNF-α, and TGF-β1. The protein and mRNA expression of TGF-β1, fibrinogen, and α-SMA in the rat peritoneum and adhesion tissues were also down-regulated due to resveratrol intervention. Conclusion: Resveratrol can effectively prevent the formation of postoperative intra-abdominal adhesions in a rat model. This effect may be related to the suppression of inflammatory cytokine expression in the injured peritoneum by resveratrol. This study suggests that resveratrol may be a new and effective anti-adhesive agent that is worthy of further study and has potential application value.

show abstract

Section: Discussionmentioning

confidence: 53%

Effect of Resveratrol on the Prevention of Intra-Abdominal Adhesion Formation in a Rat Model

Wei

Chen

Wang

et al. 2016

Cell Physiol Biochem

View full text Add to dashboard Cite

show abstract

“…SIRT1 activators have a favorable safety profile and are currently being tested in phase 2 human trials (https://ClinicalTrials.gov) (48). Therefore, their usage as TB HDT could have important clinical implications through (i) avoiding the development of resistance by targeting the host and not the pathogen, (ii) shortening the course of multidrug therapy for TB, and (iii) improving anti- Mtb immune responses to facilitate pathogen clearance.…”

Section: Discussionmentioning

confidence: 99%

Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis

et al. 2017

View full text Add to dashboard Cite

Mycobacterium tuberculosis (Mtb) executes a plethora of immune-evasive mechanisms, which contribute to its pathogenesis, limited efficacy of current therapy, and the emergence of drug-resistant strains. This has led to resurgence in attempts to develop new therapeutic strategies/targets against tuberculosis (TB). We show that Mtb down-regulates sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD+)–dependent deacetylase, in monocytes/macrophages, TB animal models, and TB patients with active disease. Activation of SIRT1 reduced intracellular growth of drug-susceptible and drug-resistant strains of Mtb and induced phagosome-lysosome fusion and autophagy in a SIRT1-dependent manner. SIRT1 activation dampened Mtb-mediated persistent inflammatory responses via deacetylation of RelA/p65, leading to impaired binding of RelA/p65 on the promoter of inflammatory genes. In Mtb-infected mice, the use of SIRT1 activators ameliorated lung pathology, reduced chronic inflammation, and enhanced efficacy of anti-TB drug. Mass cytometry–based high-dimensional analysis revealed that SIRT1 activation mediated modulation of lung myeloid cells in Mtb-infected mice. Myeloid cell–specific SIRT1 knockout mice display increased inflammatory responses and susceptibility to Mtb infection. Collectively, these results provide a link between SIRT1 activation and TB pathogenesis and indicate a potential of SIRT1 activators in designing an effective and clinically relevant host-directed therapies for TB.

show abstract

“…Furthermore, Samsami-Kor et al performed a pilot study on patients with ulcerative colitis showing that 6 weeks of resveratrol supplementation was able to improve quality of life in patients with active colitis at least partially through inflammation reduction. However, further studies with longer duration are needed to confirm the clinical application of resveratrol [24]. …”

Section: Introductionmentioning

confidence: 99%

Sex Differences in the Effect of Resveratrol on DSS-Induced Colitis in Mice

Wagnerová

Bábíčková

Lipták

et al. 2017

Gastroenterology Research and Practice

View full text Add to dashboard Cite

Resveratrol is a natural polyphenol studied for its possible protective properties in inflammatory bowel diseases. Moreover, it has been shown to interact with estrogen receptors. In the present study, we aimed to investigate possible diverse effects of resveratrol on female and male mice in DSS-induced colitis. Thirty-seven C57BL/6 mice (21 female and 16 male) were divided into three groups for each sex. The first group received pure water (CTRL). The other two groups received 1.5% dextran sulfate sodium (DSS) to induce colitis from which one group was treated with resveratrol (DSS + RSV). Intake of 1.5% DSS caused weight loss in all DSS groups compared to control mice. Weight loss, stool consistency, and discomfort did not show any protective effect of resveratrol in males and showed even adverse effects in females. In females, the activity of myeloperoxidase was lower compared to that in males. However, colon length and spleen weight showed no sex differences, which can indicate the induction of only mild colitis in mice. Resveratrol did not have any effect on TNF-alpha levels. Taken together, these results for the first time propose possible diverse effects of resveratrol in DSS-induced colitis model depending on the sex of the animal. However, this conclusion must be confirmed by further analyses.

show abstract

Anti-Inflammatory Effects of Resveratrol in Patients with Ulcerative Colitis: A Randomized, Double-Blind, Placebo-controlled Pilot Study

Cited by 167 publications

References 17 publications

Effect of Resveratrol on the Prevention of Intra-Abdominal Adhesion Formation in a Rat Model

Effect of Resveratrol on the Prevention of Intra-Abdominal Adhesion Formation in a Rat Model

Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis

Sex Differences in the Effect of Resveratrol on DSS-Induced Colitis in Mice

Contact Info

Product

Resources

About