Anti-inflammatory effects of the extract of <i>Solanum nigrum</i> L. on an acute ear edema mouse model

Yeom, Young-Eun; Kim, Min Ah; Kim, Jin; Lee, Chang-Moon

doi:10.1080/10667857.2019.1638671

Cited by 16 publications

(6 citation statements)

References 24 publications

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“…Yeom et al showed in the TPA-induced acute ear edema mouse model that the cell viability in fruit extract of S. nigrum in 80% ethanol was 51.35% at the concentration of 0.125 mg/ml. The NO production in S. nigrum fruit extract in 80% ethanol decreased to 4.1%, 16.1%, 61.0%, and 79.8% at concentrations of 0.125, 0.250, 0.500, and 1.000 mg/ml, respectively, and could also relieve edema and decrease the thickness of ear tissue in vivo , probably accounting for the abundance of alkaloid and flavonoid ( Yeom et al, 2019 ). Similar results in acute and subacute rat models, and the hydroalcoholic extracts of S. nigrum showed less deposition of macrophages and more deposition of collagen fibres and exhibited organ protection properties (liver, stomach, and kidney), perhaps owing to the presence of steroidal alkaloids and steroidal saponins of S. nigrum ( Aryaa and Viswanathswamy, 2017 ).…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Solanum nigrum Linn.: An Insight into Current Research on Traditional Uses, Phytochemistry, and Pharmacology

Chen¹,

Dai²,

Liu³

et al. 2022

Front. Pharmacol.

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Solanum nigrum Linn., is a common edible medicinal herb of the Solanaceae family which is native to Southeast Asia and is now widely distributed in temperate to tropical regions of Europe, Asia, and America. Traditionally, it has been used to treat various cancers, acute nephritis, urethritis, leucorrhea, sore throat, toothache, dermatitis, eczema, carbuncles, and furuncles. Up to now, 188 chemical constituents have been identified from S. nigrum. Among them, steroidal saponins, alkaloids, phenols, and polysaccharides are the major bioactive constituents. Investigations of pharmacological activities of S. nigrum revealed that this edible medicinal herb exhibits a wide range of therapeutic potential, including antitumor, anti-inflammatory, antioxidant, antibacterial, and neuroprotective activities both in vivo and in vitro. This article presents a comprehensive and systematic overview of the botanical, traditional uses, phytochemical compositions, pharmacological properties, clinical trials, and toxicity of S. nigrum to provide the latest information for further exploitation and applications of S. nigrum in functional foods and medicines.

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Section: Pharmacological Activitiesmentioning

confidence: 99%

Solanum nigrum Linn.: An Insight into Current Research on Traditional Uses, Phytochemistry, and Pharmacology

Chen¹,

Dai²,

Liu³

et al. 2022

Front. Pharmacol.

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show abstract

“…It is investigated that patients with severe COVID-19 are also suffering from acute respiratory distress syndrome due to increased levels of proinflammatory cytokines [ 139 ]. In vitro and in vivo studies performed on different plant parts and active constituents of S. nigrum from berries, leaves, and stems prove anti-inflammatory activity [ 65 , 67 – 70 , 140 ]. Methanolic extract of S. nigrum fruits at 125, 250, and 275 mg/kg doses showed significant anti-inflammatory activity by inhibiting the edema caused by carrageenan [ 140 ].…”

Section: Solanum Nigrum In Covid-19 With Special Emphasis On...mentioning

confidence: 99%

Solanum nigrum L. in COVID-19 and post-COVID complications: a propitious candidate

et al. 2023

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COVID-19 is caused by severe acute respiratory syndrome coronavirus-2, SARS-CoV-2. COVID-19 has changed the world scenario and caused mortality around the globe. Patients who recovered from COVID-19 have shown neurological, psychological, renal, cardiovascular, pulmonary, and hematological complications. In some patients, complications lasted more than 6 months. However, significantly less attention has been given to post-COVID complications. Currently available drugs are used to tackle the complications, but new interventions must address the problem. Phytochemicals from natural sources have been evaluated in recent times to cure or alleviate COVID-19 symptoms. An edible plant, Solanum nigrum, could be therapeutic in treating COVID-19 as the AYUSH ministry of India prescribes it during the pandemic. S. nigrum demonstrates anti-inflammatory, immunomodulatory, and antiviral action to treat the SARS-CoV-2 infection and its post-complications. Different parts of the plant represent a reduction in proinflammatory cytokines and prevent multi-organ failure by protecting various organs (liver, kidney, heart, neuro, and lung). The review proposes the possible role of the plant S. nigrum in managing the symptoms of COVID-19 and its post-COVID complications based on in silico docking and pharmacological studies. Further systematic and experimental studies are required to validate our hypothesis.

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“…Hasil pengujian menunjukkan bahwa pada dosis ekstrak air dan etanol 250 mg/mL terjadi pengurangan volume edema telinga pada volume masing-masing yaitu 0,57±0,09 dan [11] 0,52±0,05 mg/mm 2 . Jika dibandingan dengan kontrol yaitu indometasin dengan volume edema yaitu 0,61±0,02 mg/mm 2 , hal ini menunjukkan bahwa ekstrak buah leunca memiliki aktivitas antiinflamasi yang lebih baik [16]. Pada model tikus inflamasi yang diinduksi CFA, digunakan ekstrak etanol daun leunca 100 dan 200 mg/kg sebagai subjek uji.…”

Section: Hasil Dan Pembahasanunclassified

“…Pada sampel yang digunakan yaitu Ekstrak air dan etanol 80% dari buah serta herba leunca dengan konsentrasi 0,125; 0,250; 0,500; dan 1 mg/mL menunjukkan bahwa terdapat pengurangan produksi nitric oxide (NO) baik pada ekstrak etanol maupun ekstrak air. Pada ekstrak etanol menunjukkan penurunan masing-masing menjadi 4,1; 16,1; 61,0; dan 79,8% sedangkan pada kelompok yang diberi ekstrak buah air produksi NO menurun masing-masing menjadi 35,6; 32,8; 40,8; dan 76,0% [16]. Selain menggunakan ekstrak, terdapat juga penelitian yang menggunakan senyawa hasil isolasi dari tanaman leunca.…”

Section: Hasil Dan Pembahasanunclassified

Kajian Literatur Potensi dan Mekanisme Tanaman Leunca (Solanum nigrum L.) sebagai Nutrasetikal Antiinflamasi

I Kadek Sindhu Satya Mahindra T,

I Wayan Martadi Santika

2023

WSNF

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Inflamasi merupakan suatu respon alami tubuh dalam menanggapi rangsangan berbahaya, menghilangkan iritan, dan sel-sel rusak. Namun, aktivitas inflamasi yang berlebihan dapat menimbulkan dampak imunopatologis terhadap tubuh. Tanaman Leunca (Solanum nigrum L.) yang sering dimanfaatkan masyarakat sebagai pangan mengandung senyawa flavonoid yang memiliki aktivitas sebagai antiinflamasi. Kajian literatur ini bertujuan untuk mengetahui potensi dan mekanisme leunca sebagai agen antiinflamasi. Tinjauan ini dilakukan melalui pencarian hasil penelitian yang telah dipublikasikan secara online menggunakan search engine seperti Google Scholar dan PubMed dalam lingkup nasional dan internasional dengan kata kunci Solanum nigrum L. as antiinflammatory agent. Literatur yang diperoleh diseleksi dengan pedoman Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) yang menghasilkan 9 jurnal yang sesuai dengan kriteria inklusi dan eksklusi. Berdasarkan hasil menunjukkan bahwa leunca memiliki potensi sebagai agen antiinflamasi. Leunca memiliki mekanisme sebagai inhibitor pada jalur pensinyalan NF-κB, ERK1/2, Akt dan STAT1 serta sebagai inhibitor agen proinflamasi seperti iNOS, COX2 PGE2, IL-1, IL-2, IL-1β, IL-6, CXCL9, PGE2, NO, dan TNF-α.

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Anti-inflammatory effects of the extract of Solanum nigrum L. on an acute ear edema mouse model

Cited by 16 publications

References 24 publications

Solanum nigrum Linn.: An Insight into Current Research on Traditional Uses, Phytochemistry, and Pharmacology

Solanum nigrum Linn.: An Insight into Current Research on Traditional Uses, Phytochemistry, and Pharmacology

Solanum nigrum L. in COVID-19 and post-COVID complications: a propitious candidate

Kajian Literatur Potensi dan Mekanisme Tanaman Leunca (Solanum nigrum L.) sebagai Nutrasetikal Antiinflamasi

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