Anti-inflammatory flavanol glycosides fromSaraca asocabark

Abstract

Saraca asoca (Roxb.) de Wilde, a common tree of India, is popularly used in the Ayurvedic and modern herbal systems of medicine for genito-urinary problems of women. Considering the reported antimicrobial or anti-inflammatory effect of S. asoca bark against such infections, we studied the anti-inflammatory activity-guided isolation of active compounds from methanol extract. The methanol extract of bark has yielded 10 compounds out of which 3'-deoxyepicatechin-3-O-β-D-glucopyranoside (6) and 3'-deoxycatechin-3-O-α-L-rhamnopyranoside (8) have been found to be in vitro and in vivo active. 3',5-Dimethoxy epicatechin (3), 3'-deoxyepicatechin-3-O-β-D-glucopyranoside (6), 3'-deoxycatechin-3-O-α-L-rhamnopyranoside (8) and epigallocatechin (9) are being reported for the first time from S. asoca.

Kingiodendron pinnatum , a pharmacologically effective alternative for Saraca asoca in an Ayurvedic preparation, Asokarishta

“…Saraca asoca bark, the main ingredient of Asokarishta has been reported to inhibit cyclooxygenase activity 22 and prostaglandin synthesis 13 and to have anti-inflammatory property. 32 In the present study, Asokarishta shows anti-inflammatory activity in animal models. This information suggests that the inhibition of cyclooxygenase and prostaglandin might be the reason for Asokarishta's clinical efficacy.…”

Antifungal Activity of Leaf Extracts of Polyalthia Longifolia (Sonn.) Benth. And Hook. F. Against Rhizoctonia Solani

“…It has been proved that there is a important relationship between extract and active compounds. (Callixte et al, 2020;Sheekh et al, 2020).There are several methods which are used to evaluate antifungal activity of plant extract (kohli et al, 2002).In support to this hypothesis many researchers found Polyalthia longifolia has Pharmacological activities, namely anti-inflammatory, anti-arthritic, antiulcer, anticancer, antioxidant, antidiabetic and analgesic activities has been reported in Polyalthia plant (Cibin et al, 2012;Gupta et al, 2014;Nag et al, 2015;Ahmad et al, 2016).). P. longifolia possess antiulcer activities (Malairajan et al, 2008), hepato protective anti-inflammatory (Tanna et al, 2009) activities, hypoglycemic and anti hyperglycemic (Nair et al, 2007) activities, and antimicrobial activity (Faizi et al, 2003;Murthy et al, 2005;Nair and Chanda, 2006).…”

Phytochemical, Botanical and Biological Paradigm of Astavarga Plants- The Ayurvedic Rejuvenators

“…Recent extensive surveys by Acharya Balkrishna (Table 1). In continuation of our interest in investigating and reviewing some of the Ayurvedic plants, we have taken up the phytochemical, botanical and biological paradigm of Astavarga group to inculcate fresh interest in nurturing and protecting them from extinction [13][14][15][16][17][18][19][20][21].…”