Anti-inflammatory glycoterpenoids from Scrophularia auriculata

Giner, Rosa M.; Villalba, Marı́a-Luisa; Recio, M. C.; Máñez, Salvador; Cerdá-Nicolás, Miguel; Rı́os, José-Luis

doi:10.1016/s0014-2999(99)00846-8

Cited by 74 publications

(75 citation statements)

References 26 publications

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“…While most publications focus on the anti-inflammatory properties (11,12), this work demonstrates for the first time the anti-proliferative and Figure 10. Effect of S. lucida extract on the NF-κB transactivation activity.…”

Section: Discussionmentioning

confidence: 74%

“…Giner et al (11) investigated the activity of four glycoterpenoids (two saponins, verbascosaponin A and verbascosaponin, and two iridoids, scropolioside A and scrovalentinoside) isolated from S. auriculata ssp. pseudoauriculata in different models of acute and chronic inflammation and demonstrated the anti-inflammatory activity in mice against different edema inducers.…”

Section: Discussionmentioning

confidence: 99%

“…Since ancient times, different Scrophularia species have been used as remedies for some medical treatments, including scabies, eczema, psoriasis, inflammatory diseases and tumours (8). There are more than 220 genera of the Scrophulariaceae family in which the genus Scrophularia is known for the rich presence of sugar esters and iridoid glycosides (9,10), and a few publications describe the anti-inflammatory properties of different Scrophularia species (11,12). Oleanonic and ursolonic acids extracted from the root of S. ningpoensis Hemsl were found to be cytotoxic against a series of human cancer cell lines (MCF7, K562 and A549) (10).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Scrophularia extracts on tumor cell proliferation, death and intravasation through lymphoendothelial cell barriers

et al. 2012

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Abstract. Different studies describe the anti-inflammatory effects of Scrophularia species, a medicinal plant widely used in folk medicine since ancient times. As knowledge regarding the anti-neoplastic properties of this species is rather limited, we investigated the influence of methanol extracts of different Scrophularia species on cell proliferation, cell death, and tumour cell intravasation through the lymph endothelial barrier. HL-60 leukaemia cells were treated with methanol extracts of different Scrophularia species leading to strong growth inhibition and high cell death rates. The expression of cell cycle regulators, oncogenes and cell death inducers was determined by Western blot analysis. Furthermore the effect of S. lucida was studied in an NF-κB reporter assay, and in a novel assay measuring 'circular chemo-repellent-induced defects' (CCID) in lymph endothelial monolayers that were induced by MCF-7 breast cancer spheroids. Methanol extracts of Scrophularia species exhibited strong anti-proliferative properties. S. floribunda extract inhibited G2/M-and later on S-phase and S. lucida inhibited S-phase and in both cases this was associated with the down-regulation of c-Myc expression. Extracts of S. floribunda and S. lucida led to necrosis and apoptosis, respectively. Furthermore, S. lucida, but not S. floribunda, effectively attenuated tumour cell intravasation through lymph endothelial cell monolayers, which correlated with the inhibition of NF-κB. S. lucida exhibited promising anti-neoplastic effects and this was most likely due to the downregulation of various cell cycle regulators, proto-oncogenes and NF-κB and the activation of caspase-3.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Scrophularia extracts on tumor cell proliferation, death and intravasation through lymphoendothelial cell barriers

et al. 2012

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“…Acylated derivatives showed excellent anti-inflammatory activity as compared to that of saponins (Anam, 2001). Giner et al (2000) also demonstrated that verbascosaponin A and verbascosaponin, isolated from Scrophularia auriculata, significantly inhibited the mouse paw edema induced by carrageenan and ear edema induced by single and multiple doses of TPA.…”

Section: Resultsmentioning

confidence: 83%

Antinociceptive and Anti-Inflammatory Effects of Saponin and Iridoid Glycosides from Verbascum pterocalycinum var. mutense Hub.-Mor.

Akkol

Tatlı

Akdemir

2007

Zeitschrift Für Naturforschung C

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The anti-inflammatory and antinociceptive properties of four major compounds from the flowers of Verbascum pterocalycinum var. mutense were investigated. Saponin glycosides called ilwensisaponin A and C and iridoid glycosides known as ajugol and picroside IV were isolated from the methanolic extract. A dose-related anti-inflammatory and antinociceptive response were obtained in this study at doses of 100 and 200 mg/kg. The results of the evaluation of the anti-inflammatory activity induced by carrageenan and PGE 1 showed that this species possesses active constituents that could diminish the cyclooxygenase activitiy. No effects were observed in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema model. Our results support the anti-inflammatory and analgesic effects of Verbascum pterocalycinum var. mutense. Ilwensisaponins A and C could explain in part the anti-inflammatory and analgesic activities of this species. Although antinociceptive and anti-inflammatory activities of ajugol and picroside IV were found insignificant in the statistical analysis, ilwensisaponin A and C showed notable activity without inducing any apparent acute toxicity as well as gastric damage.

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“…Both iridoids were active on the delayed type hypersensitivity reaction. They significantly reduced the inflammatory lesion and suppressed the cellular infiltration [44].…”

Section: Fig 2: Structures Of Compounds Having Anti-inflammatory Potmentioning

confidence: 95%

Terpenoids as Source of Anti-Inflammatory Compounds

Prakash

2017

Asian J Pharm Clin Res

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Terpenoids accounts for the major class of secondary metabolites produced by plants. It shows defense activity against environmental stress and help to heal injuries. Medicinal plants are rich in monoterpenoids, diterpenoids, sesquiterpenes, triterpenes, tetraterpenes, and ceramide. A number of therapeutic applications such as antibacterial, antimicrobial, antitumor, anti-inflammatory activity have been identified. Terpenoids are compounds similar to terpenes derived from 5-carbon monomer isoprene units. The review puts and detail insight on different class of compounds isolated from natural source from 2000 to 2016 showing anti-inflammatory potential of pharmacologically interesting agent and their mechanism of action.

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Anti-inflammatory glycoterpenoids from Scrophularia auriculata

Cited by 74 publications

References 26 publications

Effects of Scrophularia extracts on tumor cell proliferation, death and intravasation through lymphoendothelial cell barriers

Effects of Scrophularia extracts on tumor cell proliferation, death and intravasation through lymphoendothelial cell barriers

Antinociceptive and Anti-Inflammatory Effects of Saponin and Iridoid Glycosides from Verbascum pterocalycinum var. mutense Hub.-Mor.

Terpenoids as Source of Anti-Inflammatory Compounds

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