Anti-inflammatory isoflavonoids from the rhizomes of Iris germanica

Rahman, Atta-ur; Nasim, Shama; Baig, Irfan Ahmad; Jalil, Saima; Orhan, İlkay Erdoğan; Şener, Bilge; Choudhary, M. Iqbal

doi:10.1016/s0378-8741(03)00055-2

Cited by 88 publications

(52 citation statements)

References 20 publications

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“…In this experiment, intrahippocampal injection of the aggregated Aβ1-42 significantly induced impairments in cognitive ability in the rat. In our study, we have found that aqueous extract of I. germanica L. can improve the cognitive function (learning and memory) in AD model rat induced by Aβ1 it has been found that I. germanica has potent antioxidant and anti-inflammatory properties (Nadaroglu et al, 2007;Rahman et al, 2003). Inflammation and oxidative damage are two factors that implicate in AD pathogenesis.…”

Section: Discussionmentioning

confidence: 63%

“…Iris germanica L. which is known as "Irsa" in traditional Persian medicine, can be widely found in various geographical regions all over the world and is cultivated for decorative purposes, as well (Rahman et al, 2003). Iris species are rich sources of isoflavonoids.…”

Section: Introductionmentioning

confidence: 99%

“…The rhizomes have been used to manage some neurodegenerative disorders including AD in traditional Persian medicine (Choudhary et al, 2005). Several species of the genus Iris have been reported to exhibit a variety of biological functions including anti-bacterial, anti-ulcer and anti-inflammatory properties (Rahman et al, 2003). To our knowledge, there is no scientific report on the beneficial effect of I. germanica on neurodegenerative disorders.…”

Section: Introductionmentioning

confidence: 99%

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Protective Effect of Iris Germanica L. In Β-Amyloid-Induced Animal Model of Alzheimer’s Disease

Borhani

Sharifzadeh

Farzaei

et al. 2017

Afr J Tradit Complement Altern Med

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Background: Alzheimer's disease (AD) is the most common cause of dementia that is an irretrievable chronic neurodegenerative disease. In the current study, we have examined the therapeutic effects of Iris germanica extract on Amyloid β (Aβ) induced memory impairment. Materials and Methods: Wistar rats were divided into five groups of 8 per each. Groups were as followed: control group which were normal rats without induction of AD, Aβ group which received Aβ (50 ng/side), iris 100 group which received Aβ + Iris (100 mg/kg), iris 200 group which received Aβ + Iris (200 mg/kg), and iris 400 group which received Aβ + Iris (400 mg/kg). AD was established by intrahippocampal injection of 50 ng/μl/side Aβ1-42. The day after surgery, animals in treatment groups received different doses of the aqueous extract of Iris by gavage for 30 days. Morris water maze test (MWM) was performed to assess the effects of I. germanica on learning and memory of rats with Aβ induced AD. Results: Data from MWM tests, including escape latency and traveled distance, demonstrated that I. germanica extract could markedly improve spatial memory in comparison to control. Moreover, the plant had a significantly better effect on the performance of AD rats in the probe test. Conclusion: I. germanica extract can successfully reverse spatial learning dysfunction in an experimental model of AD. Further neuro psyco-pharmacological studies are mandatory to reveal the mechanism of action of this natural remedy in the management of AD symptoms.

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Section: Discussionmentioning

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Protective Effect of Iris Germanica L. In Β-Amyloid-Induced Animal Model of Alzheimer’s Disease

Borhani

Sharifzadeh

Farzaei

et al. 2017

Afr J Tradit Complement Altern Med

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“…There are large amounts of phenol-glucosidic compounds in the bulbs of the G. sisyrinchium (L.) Parl. (Rahmana et al 2003;Damirov et al, 1996) which inhibits the growth of P. placenta on beech wood and Scots pine. It is thought that Oleander may contain many other unknown or unresearched compounds (Inchem, 2005), that may have effects on the fungi.…”

Section: Resultsmentioning

confidence: 99%

Application of extracts from the poisonous plant, Nerium Oleander L., as a wood preservative

Göktaş¹,

Mammadov²,

Duru³

et al. 2007

Afr. J. Biotechnol.

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The antifungal properties of poisonous plant extracts from oleanders (Nerium oleander L.) were determined when used as a wood preservative. The extract was prepared from oleanders leaves and flowers in 96% ethyl alcohol. The wood blocks of Turkish oriental beech (Fagus orientalis L.) and Scots pine (Pinus sylvestris L.) were impregnated with the extracts. The abilities of the extract to suppress attack by Postia placenta (Fr.) (brown rot) and Trametes versicolor (L: Fr.) Quel. (a white-rot) was investigated. Treated blocks were exposed to P. placenta and T. versicolor attacks for 12 weeks by following the soil-block method. While untreated wood specimens have weight loss ranging between 27.37 and 30.66% for P. placenta and 8.64 and 24.06% for T. versicolor, the wood treated with the extracts is of weight loss between 5.54 and 10.98% for P. placenta, and between 5.02 and 28.25% for T. versicolor. The lowest weight loss was found to be for beech wood (5.02%) impregnated with the extract of oleander at a concentration level of 0.25% against T. versicolor. While the highest weight loss was also on the beech wood (28.25%) treated with the same extract at the level of 0.50% concentration against T. versicolor. In conclusion, the extracts could be used as effective wood preservative.

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“…Certain extracts or active principles obtained from plants of the Iridaceae family have a wide range of biological activities, including anti-bacterial, antiviral, antiprotozarian, antioxidant, anticancer, citotoxic, antinociceptive, and antiinflammatory and immunomodulating activity (Bianchi and Ceriotti 1975;Hosseinzadeh and Younesi 2002;Rahman et al 2003). Cipura paludosa (Iridaceae) has been used in traditional medicine against disorders such as inflammations, infections, renal tract affections and painful processes (Corrêa 1984).…”

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confidence: 99%

Evaluation of antinociceptive and anti-inflammatory activities of the topical preparation of Cipura paludosa (Iridaceae)

et al. 2014

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Alho do mato (Cipura paludosa, Iridaceae) is a medicinal plant found in the Amazon rain forest, North of Brazil. It has been used to treat algic, inflammatory and infectious processes. The aim of this study was to evaluate the anti-inflammatory and antinociceptive action of the crude Cipura paludosa ethanolic extract at concentrations ranging between 2.0 and 4.0% in Oil and Water cream formulations for topical use. The physical-chemical stability of the formulations was monitored over a six-month period with the use of accelerated stability tests. In order to evaluate the anti-inflammatory and antinociceptive activities, we used a paw edema test induced by carrageenan and a formalin test, respectively. The paw edema test showed that there was a statistical difference in the control group in relation to the treatments. The formalin test did not confirm antinociceptive action of the treatments with the extract in the early phase of the test. However, statistical difference was confirmed for the treatments in relation to the control in the late phase. The antinociceptive and anti-inflammatory activities of Cipura paludosa preparations, as demonstrated in the results, at least partially support the ethno-medical uses of this plant. KEYWORDS: Oil and Water Cream, medicinal plant, paw edema test, formalin test.Avaliação das atividades antinociceptiva e anti-inflamatória de preparação tópica de Cipura paludosa (Iridaceae) RESUMO Allho do mato (Cipura paludosa, Iridaceae) é uma planta medicinal encontrada na floresta Amazônica, norte do Brasil. Essa planta tem sido usada para tratar dores, processos inflamatórios e infecciosos. O objetivo do estudo foi avaliar a ação antiinflamatória e antinociceptiva do extrato bruto etanólico de Cipura paludosa, nas concentrações que variaram entre 2,0 e 4,0%, em formulações de cremes óleo e água de uso tópico. A estabilidade físico-química das formulações foi monitorada ao longo de um período de seis meses, com a aplicação de ensaios de estabilidade acelerada. A fim de avaliar as atividades anti-inflamatória e antinociceptiva, utilizou-se um teste de edema de pata induzido por carragenina e um teste de formalina, respectivamente. O teste de edema de pata mostrou que houve uma diferença significativa no grupo controle em relação aos tratamentos. O teste da formalina não confirmou efeito antinociceptivo dos tratamentos com o extrato, na primeira fase do ensaio. No entanto, a diferença estatística foi confirmada para os tratamentos em relação ao controle na segunda fase. As atividades antinociceptiva e anti-inflamatória das preparações com Cipura paludosa confirmam de forma parcial o uso etno-médico desta planta. PALAVRAS-CHAVES: Creme óleo e água, planta medicinal, teste edema de pata, teste de formalina. Evaluation of antinociceptive and anti-inflammatory activities of the topical preparation of Cipura paludosa (Iridaceae)

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Anti-inflammatory isoflavonoids from the rhizomes of Iris germanica

Cited by 88 publications

References 20 publications

Protective Effect of Iris Germanica L. In Β-Amyloid-Induced Animal Model of Alzheimer’s Disease

Protective Effect of Iris Germanica L. In Β-Amyloid-Induced Animal Model of Alzheimer’s Disease

Application of extracts from the poisonous plant, Nerium Oleander L., as a wood preservative

Evaluation of antinociceptive and anti-inflammatory activities of the topical preparation of Cipura paludosa (Iridaceae)

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