Anti-Inflammatory Metabolite Production in the Gut from the Consumption of Probiotic Yogurt Containing<i>Bifidobacterium animalis</i>subsp.<i>lactis</i>LKM512

Matsumoto, Mitsuharu; Benno, Yoshimi

doi:10.1271/bbb.50464

Cited by 50 publications

(30 citation statements)

References 28 publications

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“…Supplementation of Lactobacillus and Bifidobacterium strains was also positively correlated with the spermine and spermidine levels, which has been suggested to be associated with reduced inflammation (Matsumoto and Benno 2006). Most recently, Ibrahim et al (2010) demonstrated that a commercial probiotic cheese containing L. rhamnosus and L. acidophilus was able to improve NK cells ability to kill target tumour cells and the phagocytosis activity of granulocytes and monocytes.…”

Section: Critical Points In the Modulation Of The Gut Microbiota In Ementioning

confidence: 89%

Ageing of the human metaorganism: the microbial counterpart

Biagi

Candela

Fairweather‐Tait

et al. 2011

AGE

332

206

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Human beings have been recently reviewed as ‘metaorganisms’ as a result of a close symbiotic relationship with the intestinal microbiota. This assumption imposes a more holistic view of the ageing process where dynamics of the interaction between environment, intestinal microbiota and host must be taken into consideration. Age-related physiological changes in the gastrointestinal tract, as well as modification in lifestyle, nutritional behaviour, and functionality of the host immune system, inevitably affect the gut microbial ecosystem. Here we review the current knowledge of the changes occurring in the gut microbiota of old people, especially in the light of the most recent applications of the modern molecular characterisation techniques. The hypothetical involvement of the age-related gut microbiota unbalances in the inflamm-aging, and immunosenescence processes will also be discussed. Increasing evidence of the importance of the gut microbiota homeostasis for the host health has led to the consideration of medical/nutritional applications of this knowledge through the development of probiotic and prebiotic preparations specific for the aged population. The results of the few intervention trials reporting the use of pro/prebiotics in clinical conditions typical of the elderly will be critically reviewed.

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Section: Critical Points In the Modulation Of The Gut Microbiota In Ementioning

confidence: 89%

Ageing of the human metaorganism: the microbial counterpart

Biagi

Candela

Fairweather‐Tait

et al. 2011

AGE

332

206

View full text Add to dashboard Cite

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“…Thus, a high level of ammonia is responsible for elevation of luminal and fecal pH, which might lead to changes in the intestinal microbiota in uremic patients (4). Probiotics containing Bifidobacterium species and Lactobacillus species could beneficially affect the host by suppressing the growth or epithelial invasion of pathogenic bacteria, improving intestinal barrier function, and modulating immune system activity (2,5,19,24). Few studies have assessed the possible benefit of probiotics for patients with chronic kidney disease.…”

Section: Discussionmentioning

confidence: 99%

Real-Time PCR Analysis of the Intestinal Microbiotas in Peritoneal Dialysis Patients

Wang

Lai

et al. 2012

Appl Environ Microbiol

111

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Bifidobacterium and Lactobacillus can beneficially affect the host by producing acetic acid and lactic acid, which lower pH and thereby inhibit the growth of pathogens or allow the probiotic bacteria to compete with pathogens for epithelial adhesion sites and nutrients. The transmural migration of enteric organisms into the peritoneal cavity can cause peritonitis in peritoneal dialysis (PD) patients. We hypothesized that the composition of the intestinal microbiota with regard to Lactobacillus species and Bifidobacterium species differed between PD patients and healthy controls. The aim of the study was to investigate these differences by real-time PCR analysis of fecal samples. There is a large, complex, and diverse microbial community in the human intestine. The intestinal microbiota plays an important role in digesting food, metabolizing endogenous and exogenous compounds, and producing essential vitamins. It also stimulates the immune system and prevents the colonization of the gastrointestinal tract by pathogens, and hence it influences human health (7, 9). The gastrointestinal microbiota of an adult human consists of more than 500 species, with 10 11 to 10 12 CFU per gram of stool (12,25). The predominant microorganisms are non-spore-forming, obligate anaerobes, such as Bacteroides, Fusobacterium, Eubacterium, and Bifidobacterium species. Other anaerobic bacteria found in large numbers include Lactobacillus species, various anaerobic Gram-positive cocci, and Clostridium species (4). Hida et al. studied the fecal flora of hemodialysis (HD) patients and healthy controls using traditional plating methods and found quantitative and qualitative differences between the two groups (13). It is plausible to suggest that the chronic inflammatory state in dialysis patients is in part due to a microbial imbalance in the gut, resulting in alteration of proinflammatory cytokines and production of uremic toxins from proteins fermented in the large intestine (16). Moreover, impaired intestinal barrier function in peritoneal dialysis (PD) patients allows enteric organisms to enter the peritoneal cavity by transmural migration and to cause peritonitis (8,27). Peritonitis occasionally causes death and results in significant morbidity, including catheter loss, transfer to hemodialysis, transient loss of ultrafiltration, and possible permanent membrane damage (22). Bifidobacterium and Lactobacillus can beneficially affect the host by inhibiting the growth of pathogens through production of acetic acid and lactic acid, which lower pH, or by competing with pathogens for epithelial adhesion sites and nutrients (10).To the best of our knowledge, no study has investigated the intestinal microbiota in PD patients before. The aim of this study, therefore, was to evaluate the differences in the intestinal microbiota between PD patients and healthy controls by examining fecal samples. We focused on Bifidobacterium species, Lactobacillus species, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Enterococcus species....

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“…B. animalis subsp. lactis LKM512 showed the ability to produce metabolites, suppressing the release of inflammatory cytokine TNF-α (Matsumoto and Benno, 2006).…”

Section: Discussionmentioning

confidence: 99%