Anti-inflammatory phenylpropanoid glycosides from Clerodendron trichotomum leaves

Abstract

The chromatographic separation of MeOH extract from Clerodendron trichotomum Thunberg leaves led to the isolation of three phenylpropanoid compounds. Using spectroscopic methods, the structures of these compounds were determined as beta-(3', 4'-dihydroxyphenyl)ethyl-O-alpha-L-rhamnopyranosyl (1-->3)-beta-D-(4-O-caffeoyl)-glucopyranoside, acteoside (verbascoside) (1), beta-(3', 4'-dihydroxyphenyl)ethyl-O-alpha-L-rhamnopyranosyl (1-->3)-beta-D-(6-O-caffeoyl)-glucopyranoside, isoacteoside (2), beta-(3', 4'-dihydroxyphenyl) ethyl-O-alpha-L-rhamnopyranosyl (1-->3)-beta-D-glucopyranoside, and decaffeoylacteoside (3). We measured the anti-inflammatory activity of these three phenylpropanoid compounds both in vitro (DPPH reduction assay, TBARS assay on Cu (2+)-induced oxidized LDL, PGE(2) assay) and in vivo (acetic acid induced vascular permeability in mice and carrageenan-induced hind paw edema in rats). 80% methanol fraction and acteoside had the activity.

Therapeutic agents and herbs in topical application for acne treatment

“…These include Aralia continentalis via inhibition of cyclooxygenase-2 (COX-2) and NO expression including NF-jB deactivation [117]. Clerodendron trichotomum was found to suppress PGE 2 production [118], which appropriates for inflammatory acne treatment.…”

Genetic transformation of Harpagophytum procumbens by Agrobacterium rhizogenes: iridoid and phenylethanoid glycoside accumulation in hairy root cultures

“…Flavonoids and phenylethanoid glycosides have also been detected in root tubers of H. procumbens (Burger et al 1987;Boje et al 2003). Phenylethanoid glycosides, like verbascoside and isoverbascoside have anti-inflammatory, antiproliferative and antioxidative (antiradical) activity (Nagao et al 2001;Smejkal et al 2007;Kim et al 2009). …”

A new iridoid glycoside and NO production inhibitory activity of compounds isolated from Russelia equisetiformis

“…1), along with 24 known compounds . The structures of the known compounds were identified as rehmaglutins B (2) and D (3) [6], glutinoside (4) [7], catalpol (5) [8], specioside (6) [9,10], 6-O-cis-pcoumaroylcatalpol (7) [10], verminoside (8) [11], gmelinoside A (9) [12], dolichocymboside D (10) [13], 8-epiloganic acid (11) [14], citrusin C (12) [15], 4-allyl-2,6dimetnoxyphenyl glucoside (13) [16], eugenyl b-rutinoside (14) [17], decafeoylacteoside (15) [5], acteoside (16) [5], isoacteoside (17) [5], trans-leucosceptoside A (18) [18], cis-leucosceptoside A (19) [19], crenatoside (20) [20], (7S,8R)-dihydrodehydrodiconiferyl alcohol 4-O-glucoside (21) [21], citrusin B (22) [22], tricin 7-O-glucoside (23) [23,24], tricin 4 0 -O-glucoside (24) [24,25], and vitexin (25) [26] by comparison of their spectroscopic data with those reported in the literature. , four protons for cis and trans double bonds, and five protons for a monosubstituted benzene ring were observed.…”

“…An antinociceptive effect [1] and membrane stabilizing activity [2,3], and free radical scavenging activity [4] were observed for extracts of R. equisetiformis. Russetinol glycoside and russelianoside A were identified as possible antinociceptive compounds in a 50% EtOH extract of R. equisetiformis [1]; however, the former is a known compound, acteoside [5].…”