Anti-Inflammatory Potential of Aloe Vera in Oral Mucositis Therapy: Systematic Review

CHANDRA, VERRELY CHRISTIAN; Nur’aeny, Nanan; Wahyuni, Indah Suasani

doi:10.22159/ijap.2022.v14ti.21

Cited by 4 publications

(2 citation statements)

References 30 publications

(62 reference statements)

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“…Bradykinase can act as an antioxidant by reducing excessive inflammation that can induce ROS so as to inhibit formation of ROS [27]. Aloe vera mouthwash has anti-inflammatory effects equivalent to benzydamine in patients with radiotherapyinduced oral mucositis [30].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Effect of Mouthwash Containing Zinc, Aloe Vera, and Stabilized Chlorine Dioxide for Oral Manifestation of Acute Myeloblastic Leukemia (Aml)

PERMATASANTI,

FITRIASAR,

SARI

et al. 2023

Int J App Pharm

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Objective: This paper aims to report a study regarding the successful treatment using zinc, Aloe vera, and stabilized chlorine dioxide as an antioxidant mouthwash in a patient with AML. Methods: A series of clinical examinations, including subjective and objective examinations, were done to establish the diagnosis. Results: A 9 y old boy, who was already diagnosed with AML, referred to the oral medicine division because of the hemorrhagic crust of his lips. The extra-oral examination showed severe hemorrhagic crust and erosions on the upper and lower lips. The intra-oral examination could not be evaluated in detail, but the active bleeding was seen. A hematology investigation showed pancytopenia. Patients received packed red cell (PRC) and thrombocyte concentrate (TC) blood transfusions, as well as an antioxidant mouthwash containing zinc, Aloe vera, and stabilized chlorine dioxide, for compressing the lips every 1-2 h with a duration of 30 min. Significant improvement in lip lesions was gained in a short time after blood transfusions and regular use of the mouthwash compresses. Conclusion: In this study, the mouthwash containing zinc, Aloe vera, and stabilized chlorine dioxide that can accelerate the healing process in our AML patient was estimated due to its antioxidant effects.

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Section: Discussionmentioning

confidence: 99%

Antioxidant Effect of Mouthwash Containing Zinc, Aloe Vera, and Stabilized Chlorine Dioxide for Oral Manifestation of Acute Myeloblastic Leukemia (Aml)

PERMATASANTI,

FITRIASAR,

SARI

et al. 2023

Int J App Pharm

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“…They also include the use of aloe vera in their products which has some ability to reduce mucositis after radiotherapy. (30,31) The products are presumed to result in signi cant improvements in alleviating the signs and symptoms of xerostomia in patients. (8)…”

mentioning

confidence: 99%

Efficacy of Natural Enzymes Mouthwash: a Randomised Controlled Trial

Chiam

Choo²,

Ashar

et al. 2023

Preprint

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Background: Natural enzymes mouthwash is marketed as salivary substitutes to treat xerostomia or dry mouth. However, there are minimal published studies that investigate its efficacy. Therefore, the purpose of this study is to evaluate the efficacy of natural enzymes moisturising mouthwash to treat xerostomia. Methods: A double-blind, parallel group randomised control clinical trial involving N = 49 adult participants with xerostomia was carried out. Intervention group received natural enzymes moisturising mouthwash (with the active ingredients lactoferrin, lysozyme, lactoperoxidase and glucose oxidase); while control group received benzydamine mouthwash. Mouthwashes were repacked, labelled with specific code, and were given to participants by third-party. Subjects were instructed to rinse with the mouthwash 4 times per day at a specific period, for 2 weeks. Symptoms of xerostomia were assessed using Xerostomia Inventory at day 0 and 14 of the 2-week period; together with the assessment of Clinical Oral Dryness Score (CODS), and measurement of resting and stimulated salivary flow rate. Data collected were analysed using SPSS Version 23.0. Data were compared within each arm before and after using the mouthwashes; and between both arms after using the mouthwashes. Results: A total of 48 participants completed the clinical follow-up, and n = 1 had lost of follow-up. From the 48 participants, n = 23 received natural enzymes mouthwash, while n = 25 received benzydamine mouthwash. Intervention group achieved greater reduction in symptoms of xerostomia from the baseline than control group. Intervention group also showed significantly better improvements in the cognitive perception of dry mouth and oromotor function such as chewing, swallowing and speech of the participants as well as reduction in waking up at night to drink water (p<0.05). The CODS and resting salivary flow rate were also significantly improved in intervention group (p<0.05). Natural enzymes mouthwash was also rated more pleasant to use than benzydamine mouthwash. Conclusion: Use of natural enzymes mouthwash improved signs and symptoms of xerostomia and is potentially effective to treat xerostomia. Clinical Trial Registration Number: This study was retrospectively registered in ClinicalTrials.gov ID NCT05640362 on 7 December 2022.

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Efficacy of natural enzymes mouthwash: a randomised controlled trial

Chiam,

Choo,

Ashar

et al. 2024

Clin Oral Invest

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Background:Natural enzymes mouthwash is marketed as salivary substitutes to treat xerostomia or dry mouth.However, there are minimal published studies that investigate its e cacy. Therefore, the purpose of this study is to evaluate the e cacy of natural enzymes moisturising mouthwash to treat xerostomia. Methods:A double-blind, parallel group randomised control clinical trial involving N = 49 adult participants with xerostomia was carried out. Intervention group received natural enzymes moisturising mouthwash (with the active ingredients lactoferrin, lysozyme, lactoperoxidase and glucose oxidase); while control group received benzydamine mouthwash. Mouthwashes were repacked, labelled with speci c code, and were given to participants by third-party. Subjects were instructed to rinse with the mouthwash 4 times per day at a speci c period, for 2 weeks. Symptoms of xerostomia were assessed using Xerostomia Inventory at day 0 and 14 of the 2-week period; together with the assessment of Clinical Oral Dryness Score (CODS), and measurement of resting and stimulated salivary ow rate. Data collected were analysed using SPSS Version 23.0. Data were compared within each arm before and after using the mouthwashes; and between both arms after using the mouthwashes. Results:A total of 48 participants completed the clinical follow-up, and n = 1 had lost of follow-up. From the 48 participants, n = 23 received natural enzymes mouthwash, while n = 25 received benzydamine mouthwash. Intervention group achieved greater reduction in symptoms of xerostomia from the baseline than control group. Intervention group also showed signi cantly better improvements in the cognitive perception of dry mouth and oromotor function such as chewing, swallowing and speech of the participants as well as reduction in waking up at night to drink water (p<0.05). The CODS and resting salivary ow rate were also signi cantly improved in intervention group (p<0.05). Natural enzymes mouthwash was also rated more pleasant to use than benzydamine mouthwash. Conclusion:Use of natural enzymes mouthwash improved signs and symptoms of xerostomia and is potentially effective to treat xerostomia. Clinical Trial Registration Number: This study was retrospectively registered in ClinicalTrials.gov ID NCT05640362 on

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Anti-Inflammatory Potential of Aloe Vera in Oral Mucositis Therapy: Systematic Review

Cited by 4 publications

References 30 publications

Antioxidant Effect of Mouthwash Containing Zinc, Aloe Vera, and Stabilized Chlorine Dioxide for Oral Manifestation of Acute Myeloblastic Leukemia (Aml)

Antioxidant Effect of Mouthwash Containing Zinc, Aloe Vera, and Stabilized Chlorine Dioxide for Oral Manifestation of Acute Myeloblastic Leukemia (Aml)

Efficacy of Natural Enzymes Mouthwash: a Randomised Controlled Trial

Efficacy of natural enzymes mouthwash: a randomised controlled trial

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