Anti-Inflammatory Potential of Brassicaceae-Derived Phytochemicals: In Vitro and In Vivo Evidence for a Putative Role in the Prevention and Treatment of IBD

Abstract

Inflammatory bowel disease (IBD) is a group of intestinal disorders, of unknown etiology, characterized by chronic inflammation within the gut. They are gradually becoming critical because of the increasing incidence worldwide and improved diagnosis. Due to the important side effects observed during conventional therapy, natural bioactive components are now under intense investigation for the prevention and treatment of chronic illnesses. The Brassicaceae family comprises vegetables widely consumed all over the world. In recent decades, a growing body of literature has reported that extracts from the Brassicaceae family and their purified constituents have anti-inflammatory properties, which has generated interest from both the scientific community and clinicians. In this review, data from the literature are scrutinized and concisely presented demonstrating that Brassicaceae may have anti-IBD potential. The excellent biological activities of Brassicacea are widely attributable to their ability to regulate the levels of inflammatory and oxidant mediators, as well as their capacity for immunomodulatory regulation, maintenance of intestinal barrier integrity and intestinal flora balance. Possible future applications of bioactive-derived compounds from Brassicaceae for promoting intestinal health should be investigated.

Current Knowledge on the Preparation and Benefits of Cruciferous Vegetables as Relates to In Vitro, In Vivo, and Clinical Models of Inflammatory Bowel Disease

“…rapa), the mustard Virginia pepperweed/peppergrass (Lepidium virginicum), arugula (Eruca vesicaria sativa), and wasabi (Wasabia japonica, W. koreana, and Eutrema japonicum) [ 97 , 98 ]. The presence of glucosinolates (GSLs), flavonoids, and polyphenols in crucifers provide antioxidants to scavenge ROS and anti-inflammatory agents to alleviate IBD symptoms and heal intestinal damage [ 101 , 102 ].…”

Health-Promoting Properties of Processed Red Cabbage (Brassica oleracea var. capitata f. rubra): Effects of Drying Methods on Bio-Compound Retention

“…In this sense, Koss-Mikołajczyk et al (2019) [ 16 ] described the α-amylase and α-glucosidase inhibition of red cabbage extracts related to an antidiabetic effect, and antioxidant potential measured by the FRAP [ 19 ] and DPPH assays [ 20 ] has also been reported. Other relevant functional properties such as anti-cancer [ 21 ], antimicrobial activity [ 22 ] and anti-inflammatory activity [ 23 ] have been found in red cabbage extracts as well. In addition, red cabbage extract has been shown to exhibit enhanced antibacterial and antiproliferative activity compared to other cruciferous vegetables like cauliflower, white cabbage and Chinese cabbage [ 24 ].…”

Chemical Characterization and Cytotoxic and Antioxidant Activity Evaluation of the Ethanol Extract from the Bulbs of Pancratium maritimun Collected in Sicily

“…In the frame of the ongoing research on Mediterranean plants with antioxidant properties [ 46 , 47 , 48 , 49 , 50 ], we describe here for the first time the chemical composition of a not previously studied accession of P. maritimum growing wild in Sicily. HPLC-DAD analysis is frequently applied for the detection of such compounds in Amarillidaceae and allows the separation of different derivatives and their quantification.…”