Anti-inflammatory Properties of Ethanolic Extract and 2″-O-β-d-Glucopyranosyl-vitexin Obtained from Alternanthera tenella Colla Whole Plant

The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives

“…ex DC. as anti-inflammatory agent: Sunmathi and the team had used ethanolic extract obtained from the leaves ( Sunmathi et al, 2016 ); Muniandy and the team had used 90% ethanolic extract of stems ( Muniandy et al, 2018a ); Sundar and the team had used petroleum ether and methanolic extracts of leaves ( Sundar et al, 2019 ); Kassuya and the team had used Ethanolic extract of whole plant (EEAT) as well as the isolated molecule, 2″-O-β-D-glucopyranosyl-vitexin ( Kassuya et al, 2021 ); Biella and the team had used aqueous extract of the whole plant ( Biella et al, 2008 ). Plenty of evidences obtained from the above researches leaved no doubt in that fact that Alternanthera sessilis (L.) R.Br.…”

“…Various mechanisms demonstrated by different preparations from Alternanthera sessilis (L.) R.Br. ex DC., including but not limited to cyclooxygenase -1 and -2 inhibition ( Biella et al, 2008 ), modulating NF- κB pathway ( Muniandy et al, 2018a ), leukocyte migration ( Kassuya et al, 2021 ), etc. Phytomolecules like kaempferol ( Devi et al, 2015 ; Pizzo et al, 2018 ), quercetin ( Lesjak et al, 2018 ), vitexin ( Rosa et al, 2016 ), stigmasterol ( Morgan et al, 2021 ), β-sitosterol ( Loizou et al, 2010 ), 4-hydroxybenzoic acid ( Winter et al, 2017 ), ellagic acid ( Corbett et al, 2010 ), ferulic acid ( Ozaki, 1992 ), campesterol ( Moreno-Anzúrez et al, 2017 ), spinasterol ( Jeong et al, 2010 ), β-carotene ( Uteshev et al, 2000 ), p-coumaric acid ( Pragasam et al, 2012 ), ricinoleic acid ( Vieira et al, 2001 ), and chlorogenic acid ( Hwang et al, 2013 ) may be responsible for the anti-inflammatory potential of Alternanthera sessilis (L.) R.Br.…”