Anti-inflammatory properties of the marine plant Posidonia oceanica (L.) Delile

Vasarri, Marzia; Leri, Manuela; Barletta, Emanuela; Ramazzotti, Matteo; Marzocchini, Riccardo; Degl’Innocenti, Donatella

doi:10.1016/j.jep.2019.112252

Cited by 40 publications

(54 citation statements)

References 26 publications

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“…POE has been characterized for the total content of polyphenols and carbohydrates and for its antioxidant and radical scavenging activities as described in previous works [6][7][8] and reported in Table S1 of Supplementary material.…”

Section: Np and Np-poe Preparationmentioning

confidence: 99%

“…POE and POE-loaded into nanoformulations (NP-POE and PM-POE) were tested on human neuroblastoma SH-SY5Y cell line, at the final concentration of 3 μg/mL according to data previously obtained on POE bioactivities [6][7][8].…”

Section: Np-poe and Pm-poe Effect On Shsy5y Cell Migrationmentioning

confidence: 99%

“…Specifically, the P. oceanica phytocomplex has been proven to reduce the motility of human fibrosarcoma cells and the activity of metalloproteases (MMP-2/9) through the activation of a transient autophagic process without any detectable effect on cell viability [6,7]. The anti-inflammatory mechanism of P. oceanica phytocomplex was recently elucidated [8].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Chitosan Nanoparticles and Soluplus Micelles to Optimize the Bioactivity of Posidonia oceanica Extract on Human Neuroblastoma Cell Migration

et al. 2019

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Posidonia oceanica (L.) Delile is a marine plant endemic of Mediterranean Sea endowed with interesting bioactivities. The hydroalcholic extract of P. oceanica leaves (POE), rich in polyphenols and carbohydrates, has been shown to inhibit human cancer cell migration. Neuroblastoma is a common childhood extracranial solid tumor with high rate of invasiveness. Novel therapeutics loaded into nanocarriers may be used to target the migratory and metastatic ability of neuroblastoma. Our goal was to improve both the aqueous solubility of POE and its inhibitory effect on cancer cell migration. Methods: Chitosan nanoparticles (NP) and Soluplus polymeric micelles (PM) loaded with POE have been developed. Nanoformulations were chemically and physically defined and characterized. In vitro release studies were also performed. Finally, the inhibitory effect of both nanoformulations was tested on SH-SY5Y cell migration by wound healing assay and compared to that of unformulated POE. Results: Both nanoformulations showed excellent physical and chemical stability during storage, and enhanced the solubility of POE. PM-POE improved the inhibitory effect of POE on cell migration probably due to the high encapsulation efficiency and the prolonged release of the extract. Conclusions: For the first time, a phytocomplex of marine origin, i.e., P. oceanica extract, has enhanced in terms of acqueous solubility and bioactivity once encapsulated inside nanomicelles.

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Section: Np and Np-poe Preparationmentioning

confidence: 99%

Section: Np-poe and Pm-poe Effect On Shsy5y Cell Migrationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparison of Chitosan Nanoparticles and Soluplus Micelles to Optimize the Bioactivity of Posidonia oceanica Extract on Human Neuroblastoma Cell Migration

et al. 2019

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“…Many of these compounds have special biological activities and chemical structures that can be used as potential medicines for many diseases [6,7]. Most of these marine plants extracts have been confirmed to be anti-cancer [8,9], anti-inflammatory [10,11], anti-viral [12,13], etc. Marine medicines derived from marine plant extracts have received more and more attention.…”

Section: Introductionmentioning

confidence: 99%

Exploration in the mechanism of fucosterol for the treatment of non-small cell lung cancer Based on network pharmacology and molecular docking

Lin

et al. 2020

Preprint

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Background: It has been demonstrated that fucosterol induces a therapeutic effect on cancer. However, the molecular mechanisms underlying the effects of fucosterol in the treatment of non-small cell lung cancer are still unclear.Methods: In this study, pharmMapper and GeneCards databases were utilized to gather the prediction of fucosterol targets and NSCLC-related targets. The mechanisms of fucosterol against NSCLC were identified in DAVID6.8 by enrichment analysis of GO and KEGG, and protein-protein interaction data was obtained from Sting Database. Molecular docking was used to predict the docking of GRB2. Moreover, the relationship of GRB2 expression and immune infiltrates was analyzed by TIMER database.Results: The results suggest that fucosterol acts against by candidate targets, such as MAPK1, EGFR, GRB2, IGF2, MAPK8 and SRC, which regulate biological processes including negative regulation of apoptotic process, peptidyl-tyrosine phosphorylation, positive regulation of cell proliferation. The Raf / MEK / ERK signaling pathway initiated by GRB2 maybe the most significant pathway for fucosterol to treat NSCLC.Conclusions: These results show that GRB2 is the key target for fucosterol in the treatment of NSCLC, which laying a theoretical foundation for further research and providing scientific support for the development of new drugs.

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“…Many of these compounds have special biological activities and chemical structures that can be used as potential medicines for many diseases [6,7]. Most of these marine plants extracts have been con rmed to be anti-cancer [8,9], antiin ammatory [10,11], anti-viral [12,13], etc. Marine medicines derived from marine plant extracts have received more and more attention.…”

Section: Introductionmentioning

confidence: 99%

Exploration in the mechanism of fucosterol for the treatment of non-small cell lung cancer based on network pharmacology and molecular docking

Lin

et al. 2020

Preprint

View full text Add to dashboard Cite

Background It has been demonstrated that fucosterol induces a therapeutic effect on cancer. However, the molecular mechanisms underlying the effects of fucosterol in the treatment of non-small cell lung cancer are still unclear.Methods In this study, pharmMapper and GeneCards databases were utilized to gather the prediction of fucosterol targets and NSCLC-related targets. The mechanisms of fucosterol against NSCLC were identified in DAVID6.8 by enrichment analysis of GO and KEGG, and protein-protein interaction data was obtained from Sting Database. Molecular docking was used to predict the docking of GRB2. Moreover, the relationship of GRB2 expression and immune infiltrates was analyzed by TIMER database.Results The results suggest that fucosterol acts against by candidate targets, such as MAPK1, EGFR, GRB2, IGF2, MAPK8 and SRC, which regulate biological processes including negative regulation of apoptotic process, peptidyl-tyrosine phosphorylation, positive regulation of cell proliferation. The Raf / MEK / ERK signaling pathway initiated by GRB2 maybe the most significant pathway for fucosterol to treat NSCLC.Conclusions These results show that GRB2 is the key target for fucosterol in the treatment of NSCLC, which laying a theoretical foundation for further research and providing scientific support for the development of new drugs.

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Anti-inflammatory properties of the marine plant Posidonia oceanica (L.) Delile

Cited by 40 publications

References 26 publications

Comparison of Chitosan Nanoparticles and Soluplus Micelles to Optimize the Bioactivity of Posidonia oceanica Extract on Human Neuroblastoma Cell Migration

Comparison of Chitosan Nanoparticles and Soluplus Micelles to Optimize the Bioactivity of Posidonia oceanica Extract on Human Neuroblastoma Cell Migration

Exploration in the mechanism of fucosterol for the treatment of non-small cell lung cancer Based on network pharmacology and molecular docking

Exploration in the mechanism of fucosterol for the treatment of non-small cell lung cancer based on network pharmacology and molecular docking

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