Anti-inflammatory properties of titanium in the joint environment

Overgaard, Lars C. T.; Danielsen, Nils; Bjursten, Lars Magnus

doi:10.1302/0301-620x.80b5.0800888

Cited by 15 publications

(3 citation statements)

References 25 publications

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“…Titanium particulates showed less initial reaction when injected into rats than particulates comprised of polymethylmethacrylate 22. Titanium implants showed less inflammatory response compared to polyethylene implants when placed in normal and arthritic joints of rats 23. Leukocytes associated with the surface of titanium implants in rats were less responsive to stimulation than were leukocytes from polytetrafluoroethylene implants 24.…”

Section: Discussionmentioning

confidence: 92%

Reactive oxygen species inhibited by titanium oxide coatings

Suzuki

Muyco

McKittrick

et al. 2003

J Biomedical Materials Res

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Titanium is a successful biomaterial that possesses good biocompatibility. It is covered by a surface layer of titanium dioxide, and this oxide may play a critical role in inhibiting reactive oxygen species, such as peroxynitrite, produced during the inflammatory response. In the present study, titanium dioxide was coated onto silicone substrates by radio-frequency sputtering. Silicone coating with titanium dioxide enhanced the breakdown of peroxynitrite by 79%. At physiologic pH, the peroxynitrite donor 3-morpholinosydnonimine-N-ethylcarbamide (SIN-1) was used to nitrate 4-hydroxyphenylacetic acid (4-HPA) to form 4-hydroxy-3-nitrophenyl acetic acid (NHPA). Titanium dioxide-coated silicone inhibited the nitration of 4-HPA by 61% compared to aluminum oxide-coated silicone and 55% compared to uncoated silicone. J774A.1 mouse macrophages were plated on oxide-coated silicone and polystyrene and stimulated to produce superoxide and interleukin-6. Superoxide production was measured by the chemiluminescent reaction with 2-methyl-6-[p-methoxyphenyl]-3,7-dihydroimidazo[1,2-a]pyrazin-3-one (MCLA). Titanium dioxide-coated silicone exhibited a 55% decrease in superoxide compared to uncoated silicone and a 165% decrease in superoxide compared to uncoated polystyrene. Titanium dioxide-coated silicone inhibited IL-6 production by 77% compared to uncoated silicone. These results show that the anti-inflammatory properties of titanium dioxide can be transferred to the surfaces of silicone substrates.

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Section: Discussionmentioning

confidence: 92%

Reactive oxygen species inhibited by titanium oxide coatings

Suzuki

Muyco

McKittrick

et al. 2003

J Biomedical Materials Res

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“…7 Several works have been done to evaluate the biocompatibility of polymers. [8][9][10][11][12][13] Certain polymers are suspected to induce carcinogenicity in tissues. Kinoshita et al 14,15 studied tumor formation on subcutaneous implantation of porous polyethylene on rat tissues.…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility of electroactive polymers in tissues

Kamalesh

Tan

Wang

et al. 2000

J. Biomed. Mater. Res.

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The biocompatibility of ethylene‐vinyl acetate copolymer (EVAc), polyethylene (PE), and polyaniline (PANi) films in the emeraldine (EM), nigraniline (NA) and leucoemeraldine (LM) intrinsic oxidation states were assessed through subcutaneous implantation into male Sprague‐Dawley rats beneath the dorsal skin, for a period ranging from 19 to 90 weeks. Histological examination, interstitial pressure measurement, and X‐ray photoelectron spectroscopy (XPS) were employed to determine the biocompatibility of the polymers. The polymers did not provoke inflammatory responses in the subcutaneous tissues over the entire implantation period. Characteristics features associated with tissue–implant incompatibility were not evident near the implantation. Interstitial pressure was measured to evaluate the development of tissue. Low interstitial pressure readings on the region of implantation confirmed the biocompatibility of these polymer types. The surface composition of the electroactive aniline polymers before and after the implantation was characterized by XPS. © 2000 John Wiley & Sons, Inc. J Biomed Mater Res, 52, 467–478, 2000.

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“…The production of ROS makes the implant loose with consequent decrease in the metabolic activity. 31,34–36 From this perspective, titania scavenges and removes the ROS (superoxide: O2 - and peroxynitrate: OONO − ), 35–41 which are detrimental to the metabolic activity. 42…”

Section: Introductionmentioning

confidence: 99%

Surface nanotopography-induced favorable modulation of bioactivity and osteoconductive potential of anodized 3D printed Ti-6Al-4V alloy mesh structure

et al. 2017

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The objective of the study described here is to fundamentally elucidate the biological response of 3D printed Ti-6Al-4V alloy mesh structures that were surface modified to introduce titania nanotubes with an average pore size of ∼80 nm via an electrochemical anodization process from the perspective of enhancing bioactivity. The bioactivity of the mesh structures were analyzed through immersion test in simulated body fluid, which confirmed the nucleation and growth of fine globular nanoscale apatite on the nanoporous titania-modified (anodized) mesh structure surface, and agglomerated apatite with fine flakes of apatite crystals on as-fabricated mesh structure surface, that were rich in calcium and phosphorous. The cellular activity of bioactive anodized mesh structure was explored in terms of cell-material interactions involving adhesion, proliferation, synthesis of extracellular and intracellular proteins, differentiation, and mineralization. Cells adhered with a sheet-like morphology on as-fabricated mesh structure, whereas, on anodized mesh structure, numerous filopodia-like cellular extensions interacting with nanotube pores were observed. The formation of a bioactive nanoscale apatite, cell-nanotube interactions as imaged via electron microscopy, higher expression of proteins (actin, vinculin, fibronectin, and alkaline phosphatase (ALP)), and calcium content points toward the determining role of anodized mesh structure in modulating osteoblasts functions. The unique combination of nanoporous bioactive titania and interconnected porous architecture of anodized titanium alloy mesh structure provided a multimodal roughness surface ranging from nano to micro to macroscale, which helps in attaining strong primary and secondary fixation of the implant device along with the pathway for supply of nutrients and oxygen to cells and tissue.

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Anti-inflammatory properties of titanium in the joint environment

Cited by 15 publications

References 25 publications

Reactive oxygen species inhibited by titanium oxide coatings

Reactive oxygen species inhibited by titanium oxide coatings

Biocompatibility of electroactive polymers in tissues

Surface nanotopography-induced favorable modulation of bioactivity and osteoconductive potential of anodized 3D printed Ti-6Al-4V alloy mesh structure

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