Anti-inflammatory role of sesamin in STZ induced mice model of diabetic retinopathy

Ahmad, Saif; Elsherbiny, Nehal M.; Jamal, Mohammad Sarwar; Alzahrani, Faisal; Haque, Rizwanul; Khan, Raziuddin; Zaidi, Syed Kashif; Al-Qahtani, Mohammed Hussein; Liou, Gregory I.; Bhatia, Kanchan

doi:10.1016/j.jneuroim.2016.04.002

Cited by 56 publications

(34 citation statements)

References 62 publications

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“…This further elaborates the possibility of reducing the production of inflammatory cytokines in diabetic retina. Sesamin suppresses the induced diabetic retinal injury by inhibition of TNF-α and microglia Iba-1 [87].…”

Section: Diabetic Eye Diseasementioning

confidence: 99%

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

Aquino

Barbaza

et al. 2019

Molecules

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The use of foodstuff as natural medicines has already been established through studies demonstrating the pharmacological activities that they exhibit. Knowing the nutritional and pharmacological significance of foods enables the understanding of their role against several diseases. Among the foods that can potentially be considered as medicine, is sesame or Sesamum indicum L., which is part of the Pedaliaceae family and is composed of its lignans such as sesamin, sesamol, sesaminol and sesamolin. Its lignans have been widely studied and are known to possess antiaging, anticancer, antidiabetes, anti-inflammatory and antioxidant properties. Modern chronic diseases, which can transform into clinical diseases, are potential targets of these lignans. The prime example of chronic diseases is rheumatic inflammatory diseases, which affect the support structures and the organs of the body and can also develop into malignancies. In line with this, studies emphasizing the anti-inflammatory and anticancer activities of sesame have been discussed in this review.

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Section: Diabetic Eye Diseasementioning

confidence: 99%

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

Aquino

Barbaza

et al. 2019

Molecules

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“…There are two pathways associated with inflammation that contribute to BRB breakdown: inflammatory cytokine-induced death of retinal cells pathway and proinflammatory factor-mediated leukostasis and vascular occlusion pathway [15]. Proinflammatory proteins such as inducible nitric oxide synthase (iNOS), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and VEGF are highly expressed in diabetic retinas [16–18]. These molecules prompt leukocytes to adhere to the vascular walls and stimulate the release of inflammatory cytokines and vascular permeability factors, which result in BRB breakdown and consequent vascular hyperpermeability [19].…”

Section: Introductionmentioning

confidence: 99%

Danhong Huayu Koufuye Prevents Diabetic Retinopathy in Streptozotocin-Induced Diabetic Rats via Antioxidation and Anti-Inflammation

Chen

Yao

Zhou

et al. 2017

Mediators of Inflammation

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Danhong Huayu Koufuye (DHK), a traditional Chinese prescription, is used to treat central retinal vein occlusion clinically. We previously reported that DHK prevented diabetic retinopathy (DR) in rats. Moreover, we found that it protected endothelial cells from hyperglycemia-induced apoptosis through antioxidation and anti-inflammation. Here, we investigated whether antioxidative and anti-inflammatory activities of DHK contributed to its therapeutic effect on DR in streptozotocin- (STZ-) induced diabetic rats. DHK significantly blocked the breakdown of the blood-retinal barrier (BRB) and increased the thickness of the inner nuclear layer (INL), as well as suppressed the swelling of the ganglion cell layer (GCL) in diabetic retinas. DHK remarkably increased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in plasma, and decreased serum level of nitric oxide (NO). Moreover, DHK markedly reduced the serum levels of vascular endothelial growth factor (VEGF) and intercellular adhesion molecule-1 (ICAM-1). Furthermore, DHK significantly downregulated protein expressions of VEGF and inducible NO synthase (iNOS) and mRNA expression of ICAM-1 in retinas. These results suggest that the antioxidative and anti-inflammatory activities of DHK may be important mechanisms involved in the protective effect of DHK on DR in STZ-induced diabetic rats.

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“…When the human body loses its capacity to maintain adequately the equilibrium of angiogenic mediators, some diseases can develop, including arthritis, cancer, endometriosis, psoriasis, macular degeneration related to age and proliferative diabetic retinopathy [3,4]. Macular degeneration related to age is the main cause of blindness in persons older than 60 years in industrialized countries [5].…”

Section: Introductionmentioning

confidence: 99%

Antiangiogenic activity of PLGA-Lupeol implants for potential intravitreal applications

Soares

Oliveira

Barcelos

et al. 2017

Biomedicine & Pharmacotherapy

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Uncontrolled angiogenesis is directly associated with ocular diseases such as macular degeneration and diabetic retinopathy. Implantable polymeric drug delivery systems have been proposed for intravitreal applications and in the present work, we evaluated the antiangiogenic potential of PLGA ocular implants loaded with the triterpene lupeol using in vitro and in vivo models. The drug/polymer physiochemical properties of the lupeol-loaded PLGA were validated as functionally similar using differential scanning calorimetry, Fourier transform infrared spectroscopy, and scanning electron microscopy. Interestingly, in an in vitro culture system, lupeol (100μg/mL and 250μg/mL) was capable to inhibited the proliferation as well as the migration of Human Umbilical Vein Endothelial Cells (HUVEC), without interfering in cell viability, promoting a significant reduction in the percentage of vessels (39.41% and 44.12%, respectively), compared with the control group. In vivo test, by using the chorioallantoic membrane (CAM) model, lupeol-loaded PLGA ocular implants showed antiangiogenic activity comparable to the FDA-approved anti-VEGF antibody Bevacizumab. Overall, our results suggest lupeol-loaded PLGA ocular implants were able to inhibit the angiogenic process by impairing both proliferation and migration of endothelial cells.

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Anti-inflammatory role of sesamin in STZ induced mice model of diabetic retinopathy

Cited by 56 publications

References 62 publications

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

Danhong Huayu Koufuye Prevents Diabetic Retinopathy in Streptozotocin-Induced Diabetic Rats via Antioxidation and Anti-Inflammation

Antiangiogenic activity of PLGA-Lupeol implants for potential intravitreal applications

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