Anti-inflammatory steroids from the rhizomes of Dioscorea septemloba Thunb

Zhang, Yi; Yu, Haiyang; Chao, Li-Ping; Qu, Lu; Ruan, Jing; Liu, Yanxia; Dong, Yongzhe; Han, Lifeng; Wang, Tao

doi:10.1016/j.steroids.2016.05.007

Cited by 37 publications

(11 citation statements)

References 18 publications

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“…These have also been used with other herbs to treat wind-cold exterior syndrome and wind-cold-damp bisyndromes [23,24] . Dioscorea septemloba Thunb has also been shown to have anti-in ammatory effects [25] , and also could treat wind-cold-damp bi-syndromes. All the Chinese herbal medicine work together to improve blood circulation, reduce pain, and activate joints.…”

Section: Discussionmentioning

confidence: 99%

A Retrospective Study on Recovery of Joint Function of Distal Radial Fracture After Treated with Wei’s Traumatology Guidance combined with Limbs Fumigation Fang

Yan

Kong

Miao

et al. 2020

Preprint

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Objective: To explore the clinical effect on recovery of joint function of distal radial fracture after treated with Wei’s Traumatology Guidance combined with Limbs Fumigation Fang.Methods: A retrospective analysis was conducted on 84 patients with distal radius fracture. The cases were collected from October 2017 to July 2018 in Ruijin Hospital Affiliated to Medical College of Shanghai Jiao tong University. The fractured radius of patients was firstly fixed and then treated with Wei's traumatology guidance combined with Limbs Fumigation Fang. After that, the G-W wrist function, self-rating scale (PRWE) and simplified sf-36 health scale were used to analyze the recovery of joint function of distal radial fracture before and after treatment.Results: There were significant differences in wrist function evaluation, wrist patient self-rating scale (PRWE) and simplified SF-36 health scale before and after treatment (P < 0.05).After treated with Wei’s Traumatology Guidance combined with Limbs Fumigation Fang for 3 weeks, the wrist pain, range of motion, strength and quality of life were improved a lot than before. Conclusion: Wei’s Traumatology Guidance combined with Limbs Fumigation Fang is an ideal way to restore wrist function with definite curative effect and high safety.

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Section: Discussionmentioning

confidence: 99%

A Retrospective Study on Recovery of Joint Function of Distal Radial Fracture After Treated with Wei’s Traumatology Guidance combined with Limbs Fumigation Fang

Yan

Kong

Miao

et al. 2020

Preprint

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“…In the meantime, a chromatographic prospection of the main classes of the chemical compounds was made, and the presence of phenolic compounds and terpenes were observed (data not shown). Although no chemical studies related to D. altissima were identified in the literature, the occurrence of steroids glycosides 22) , phenolic compounds 23) and steroidal saponins 24) and norclerodane diterpenoids 25) is largely reported for other species of Dioscorea. No reports on toxicity effects of D. altissima were found.…”

Section: Discussionmentioning

confidence: 99%

Mechanical properties of a glass ionomer cement incorporated with Amazon plant extract

et al. 2019

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To evaluate the mechanical properties (MP) and antimicrobial activity of a glass ionomer cement (GIC) incorporated with an antimicrobial agent from the aerial parts of Dioscorea altissima. MP were: syneresis & imbibition; solubility; elasticity module; surface microhardness and fluoride release, and the anti-Streptococcus mutans (Smut) activity was accessed by microdilution broth assay and 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) analysis. Syneresis & imbibition did not change over time for both groups, but EG showed lower values at days 7th and 30th. The control group (CG)'s and the experimental group (EG)'s weights were similar before the solubility assay, but after seven days, CG exhibited weight gain in comparison to EG. The elasticity module had no significant differences between groups. The CG showed lower surface microhardness compared to the EG. CG and EG had similar behaviors regarding fluoride release. EG showed diminished Streptococcus mutans count in comparison to CG. EG showed similar or better mechanical properties and an improvement in the antibacterial activity than the original cement.

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“…Steroidal glycosides (SGs) possess broad biological activities, such as anti-inflammatory effect [1,2], anticancer activity [3][4][5], antifungal property [6][7][8], and antiviral activity [9,10]. Moreover, steroidal glycosides are able to serve as the precursors of pharmaceutical steroids [11].…”

Section: Introductionmentioning

confidence: 99%

OcUGT1-Catalyzing Glycodiversification of Steroids through Glucosylation and Transglucosylation Actions

Xü

Kong

2020

Molecules

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Steroidal glycosides are important sources of innovative drugs. The increased diversification of steroidal glycosides will expand the probability of discovering active molecules. It is an efficient approach to diversify steroidal glycosides by using steroidal glycosyltransferases. OcUGT1, a uridine diphosphate-d-glucose (UDP-Glc)-dependent glycosyltransferase from Ornithogalum caudatum, is a multifunctional enzyme, and its glycodiversification potential towards steroids has never been fully explored. Herein, the glycodiversification capability of OcUGT1 towards 25 steroids through glucosylation and transglucosylation reactions were explored. Firstly, each of 25 compounds was glucosylated with UDP-Glc. Under the action of OcUGT1, five steroids (testosterone, deoxycorticosterone, hydrocortisone, estradiol, and 4-androstenediol) were glucosylated to form corresponding mono-glucosides and biosides. Next, OcUGT1-mediated transglucosylation activity of these compounds with another sugar donor ortho-nitrophenyl-β-d-glucopyranoside (oNPGlc) was investigated. Results revealed that the same five steroids could be glucosylated to generate mono-glucosides and biosides by OcUGT1 through transglucosylation reactions. These data indicated that OcUGT1-assisted glycodiversification of steroids could be achieved through glucosylation and transglucosylation reactions. These results provide a way to diversify steroidal glycosides, which lays the foundation for the increase of the probability of obtaining active lead compounds.

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Anti-inflammatory steroids from the rhizomes of Dioscorea septemloba Thunb

Cited by 37 publications

References 18 publications

A Retrospective Study on Recovery of Joint Function of Distal Radial Fracture After Treated with Wei’s Traumatology Guidance combined with Limbs Fumigation Fang

A Retrospective Study on Recovery of Joint Function of Distal Radial Fracture After Treated with Wei’s Traumatology Guidance combined with Limbs Fumigation Fang

Mechanical properties of a glass ionomer cement incorporated with Amazon plant extract

OcUGT1-Catalyzing Glycodiversification of Steroids through Glucosylation and Transglucosylation Actions

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