Anti-Inflammatory Substances in Wheat Malt Inducing Antisecretory Factor

Johansson, Ewa; Lange, Stefan; Oshalim, Merna; Lönnroth, Ivar

doi:10.1007/s11130-019-00767-1

Cited by 8 publications

(6 citation statements)

References 21 publications

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“…For most of the currently available therapeutic options, significant limitations remain, which raises a major concern for identifying novel therapeutic options [34]. Quercetin exerts anti-inflammatory activity in multiple different disease models [35][36][37]. Hu et al [4] found that quercetin alleviated OA by attenuating the inflammation and apoptosis of chondrocytes.…”

Section: Discussionmentioning

confidence: 99%

Quercetin modulates the gut microbiota as well as the metabolome in a rat model of osteoarthritis

et al. 2021

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Although the mechanism of osteoarthritis (OA) has been widely studied and the use of quercetin for OA therapy is well documented, the relevant characteristics of the microbiome and metabolism remain unclear. This study reports changes in the gut microbiota and metabolism during quercetin therapy for OA in a rat model and provides an integrative analysis of the biomechanism. In this study, the rats were categorized into 3 different groups: the OA model, quercetin treatment, and control groups. The OA rats was conducted using a monoiodoacetate (MIA) injection protocol. The rats in the quercetin group received daily intragastric administration of quercetin from day 1 to day 28. Stool samples were collected, and DNA was extracted. We used an integrated approach that combined the sequencing of whole 16S rRNA, short-chain fatty acid (SCFA) measurements and metabolomics analysis by mass spectrometry (MS) to characterize the functional impact of quercetin on the gut microbiota and metabolism in a rat model of OA. The use of quercetin partially abrogated intestinal flora disorder and reversed fecal metabolite abnormalities. Compared with the control rats, the OA rats showed differences at both the class level (Clostridia, Bacteroidia, and Bacilli) and the genus level (Lactobacillus and unidentified Ruminococcaceae). Acetic acid, propionic acid and 24 metabolites were significantly altered among the three groups. However, the changes were significantly abrogated in quercetintreated OA rats. Consequently, this study provided important evidence regarding perturbations of the gut microbiome and the function of these changes in a potential new mechanism of quercetin treatment.

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Section: Discussionmentioning

confidence: 99%

Quercetin modulates the gut microbiota as well as the metabolome in a rat model of osteoarthritis

et al. 2021

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“…Quercetin exerts an obvious anti-inflammatory activity in many animal species, [25][26][27] and SAA as an inflammatory marker was reduced significantly in the obesity disease cats as well as in the healthy controls. MDA concentrations were not changed in the obesity disease cats, and this phenomenon may indicate insufficiency of anti-oxidant activity of quercetin derivative.…”

Section: Discussionmentioning

confidence: 95%

<p>Effects of Supplementation with Anti-Inflammatory Compound Extracted from Herbs in Healthy and Obese Cats</p>

Kobayashi¹,

Okada²,

Ueno³

et al. 2020

VMRR

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Background: Obesity has become a serious public health problem all over the world, and prevalence of obesity has increased in cats. Obesity is characterized by continuous low-grade inflammation based on oxidative stress by excessively produced reactive oxygen species (ROS). Supplementation with anti-oxidant and anti-inflammatory compounds is very effective to relieve the obesity condition. A plant extract mixture containing Rhus verniciflua and some other herbs, Rv-PEM01-99, shows anti-oxidant and anti-inflammatory effects in animals. The aim of this study was to evaluate the effects of supplementation with Rv-PEM01-99 as an anti-inflammatory compound in healthy and obese cats. Materials and Methods: Ten healthy mix breed cats and four obesity disease cats were used. The healthy cats were randomly divided into control and test groups. Antiinflammatory compound, Rv-PEM01-99, in which quercetin derivative is the main component, was supplemented to the healthy test group and the obesity disease cats at the dose of 100-120 mg/kg/day (2.5-3.0 mg/kg/day as quercetin) for 4 weeks. Metabolites, hormones and enzymes were measured before and after the compound supplementation. Results: The anti-inflammatory compound supplementation decreased serum amyloid A (SAA) concentrations as inflammatory markers in both healthy and obesity disease cats. In obesity disease cats, plasma total cholesterol concentrations and AST and ALT activities decreased significantly after the compound supplementation. Conclusion: Quercetin derivative seems to have strong anti-inflammatory activities. In the healthy cats, anti-inflammatory compound supplementation decreased plasma NEFA and SAA concentrations. In the obesity disease cats, the compound supplementation may have alleviated obesity disease by relieving inflammation and improvement of lipid metabolism in livers.

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“…29 Quercetin has been demonstrated to exert anti-inflammatory activity in multiple disease models. [30][31][32] However, the anti-inflammatory activity of quercetin during OA development and progression is not fully understood.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, it is important to find new therapeutic agents to mitigate the development and progression of OA in vulnerable patients 29 . Quercetin has been demonstrated to exert anti‐inflammatory activity in multiple disease models 30–32 . However, the anti‐inflammatory activity of quercetin during OA development and progression is not fully understood.…”

Section: Discussionmentioning

confidence: 99%

Quercetin prevents osteoarthritis progression possibly via regulation of local and systemic inflammatory cascades

Wang

Yan

Pathak

et al. 2023

J Cellular Molecular Medi

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Due to the lack of effective treatments, osteoarthritis (OA) remains a challenge for clinicians. Quercetin, a bioflavonoid, has shown potent anti‐inflammatory effects. However, its effect on preventing OA progression and the underlying mechanisms are still unclear. In this study, Sprague–Dawley male rats were divided into five groups: control group, OA group (monosodium iodoacetate intra‐articular injection), and three quercetin‐treated groups. Quercetin‐treated groups were treated with intragastric quercetin once a day for 28 days. Gross observation and histopathological analysis showed cartilage degradation and matrix loss in the OA group. High‐dose quercetin‐group joints showed failure in OA progression. High‐dose quercetin inhibited the OA‐induced expression of MMP‐3, MMP‐13, ADAMTS4, and ADAMTS5 and promoted the OA‐reduced expression of aggrecan and collagen II. Levels of most inflammatory cytokines and growth factors tested in synovial fluid and serum were upregulated in the OA group and these increases were reversed by high‐dose quercetin. Similarly, subchondral trabecular bone was degraded in the OA group and this effect was reversed in the high‐dose quercetin group. Our findings indicate that quercetin has a protective effect against OA development and progression possibly via maintaining the inflammatory cascade homeostasis. Therefore, quercetin could be a potential therapeutic agent to prevent OA progression in risk groups.

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Anti-Inflammatory Substances in Wheat Malt Inducing Antisecretory Factor

Cited by 8 publications

References 21 publications

Quercetin modulates the gut microbiota as well as the metabolome in a rat model of osteoarthritis

Quercetin modulates the gut microbiota as well as the metabolome in a rat model of osteoarthritis

<p>Effects of Supplementation with Anti-Inflammatory Compound Extracted from Herbs in Healthy and Obese Cats</p>

Quercetin prevents osteoarthritis progression possibly via regulation of local and systemic inflammatory cascades

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