<p>Effects of Supplementation with Anti-Inflammatory Compound Extracted from Herbs in Healthy and Obese Cats</p>

Abstract

Background: Obesity has become a serious public health problem all over the world, and prevalence of obesity has increased in cats. Obesity is characterized by continuous low-grade inflammation based on oxidative stress by excessively produced reactive oxygen species (ROS). Supplementation with anti-oxidant and anti-inflammatory compounds is very effective to relieve the obesity condition. A plant extract mixture containing Rhus verniciflua and some other herbs, Rv-PEM01-99, shows anti-oxidant and anti-inflammatory effects in animals. The aim of this study was to evaluate the effects of supplementation with Rv-PEM01-99 as an anti-inflammatory compound in healthy and obese cats. Materials and Methods: Ten healthy mix breed cats and four obesity disease cats were used. The healthy cats were randomly divided into control and test groups. Antiinflammatory compound, Rv-PEM01-99, in which quercetin derivative is the main component, was supplemented to the healthy test group and the obesity disease cats at the dose of 100-120 mg/kg/day (2.5-3.0 mg/kg/day as quercetin) for 4 weeks. Metabolites, hormones and enzymes were measured before and after the compound supplementation. Results: The anti-inflammatory compound supplementation decreased serum amyloid A (SAA) concentrations as inflammatory markers in both healthy and obesity disease cats. In obesity disease cats, plasma total cholesterol concentrations and AST and ALT activities decreased significantly after the compound supplementation. Conclusion: Quercetin derivative seems to have strong anti-inflammatory activities. In the healthy cats, anti-inflammatory compound supplementation decreased plasma NEFA and SAA concentrations. In the obesity disease cats, the compound supplementation may have alleviated obesity disease by relieving inflammation and improvement of lipid metabolism in livers.

Quercetin compound effect on a horse with chronic shoulder arthritis

“…Supplementation with QC induces remarkable improvement of lipid metabolism and anti-oxidant activation in obese dogs and cats (Kawasumi et al 2018, Kobayashi et al 2020. Quercetin is one of the common avonoids found in many foods and a powerful antioxidant and has been shown to have antiin ammatory properties to reduce metabolic syndrome, muscle atrophy (Le et al 2014), cardiovascular disease (Patel et al 2018), and others (Li et al 2016).…”

“…Powdered QC was mixed with food and orally supplemented with horses. Dose of QC was settled as 3.8~4.0 mg/kg body weight /day as quercetin derivative referring to the effective dose in dogs and cats (Kawasumi et al 2018, Kobayashi et al 2020) QC was supplemented to healthy horses (No. 1 and 2) for 4 weeks, and the injured horse for 25 days.…”

“…Quercetin is a avonoid which has various functions such as antioxidant activity, anti-in ammatory action, amelioration of lipid metabolism and others (Boots et al 2008, Singh et al 2021 We have previously reported that quercetin compounds (QC), extracted from some herbs including Rhus vernici ua, showed anti-in ammatory and anti-oxidant activities in dogs and cats (Kawasumi et al 2018, Kobayashi et al 2020.…”

Measurement of paraoxonase and telomerase enzymes and HDL (high density lipoprotein) values and research of their possible relationships with each other in bloodserum of obese cats

“…Gastrointestinal Recent reports show that obesity is a growing problem in domestic cats, with approximately 25% to 40% of domestic cats being overweight or obese (1,2). Since obesity is associated with some diseases in cats (eg diabetes mellitus, hepatic lipidosis, osteoarthritis, etc.…”