Anti-Irritative Effect of Methylrosaniline Chloride (Gentian Violet)

Abstract

Background: There are no published studies of the effect of methylrosaniline chloride (MRC) on inflammation when used at the concentration recommended in the New German Formulary. A tissue-damaging effect has been described in animal studies and at higher concentrations in humans. Objective: To determine whether 0.5% MRC increases or reduces skin damage in irritative dermatitis. Methods: The study was carried out on the sodium lauryl sulfate (SLS) skin irritation model in 18 healthy volunteers. The impact of intermittent treatment with 0.5% MRC or drug-free vehicle on three SLS exposure effects was determined: reduction of stratum corneum water content (corneometry), increase in subpapillary blood flow (laser Doppler method) and barrier damage (transepidermal water loss). Results: MRC produced significant reductions in all three SLS exposure effects. Conclusions: Treatment of irritative dermatitis with 0.5% MRC is expected to produce a high clinical efficacy not only because of the compound’s established antimicrobial activity, but also because of its anti-irritative effect.

Transmission-blocking compound candidates against Plasmodium vivax using P. berghei as an initial screening

“…In ookinete transformation, MMV665941 showed the third best inhibition rate. This compound, which is also called methylrosaniline, has a dermatological topical use, (27) and may target a steroldependent function. Plasmodium parasites require sterol lipids, which they can scavenge from the host.…”

New Treatment for Percutaneous Sites in Patients with a Ventricular Assist Device: Nihon University Crystal Violet Method

“…It has also been reported that cutaneous/mucous membrane disorders caused by methylrosanilinium chloride are mainly due to a primary concentration-dependent irritant effect, while a lower concentration does not affect epithelial regeneration. [15][16][17] Due to its potent antibacterial activity against MRSA, methylrosanilinium chloride has increasingly being used for the treatment of prosthetic graft infection 11,12) and decubitus ulcer 13) over the past several years. However, liquid preparations of methylrosanilinium chloride were used in previous studies and a method of percutaneous site disinfection for VAD patients has not been established.…”

Gentian violet: Revisited

“…Gloor et al noted anti-irritative effect of 0.5% gentian violet. 22 They found that 0.5% gentian violet reduces skin damage in irritative dermatitis. It also provides immediate pain relief in acute painful eczematous lesions.…”