Anti-ischemic effect of Aurantii Fructus on contractile dysfunction of ischemic and reperfused rat heart

Kang, Moonkyu; Kim, Jong-Hoon; Cho, Chongwoon; Chung, Hwan‐Suck; Kang, Chang-Woon; Kim, Yangseok; Shin, Monica; Hong, Min; Bae, Hyunsu

doi:10.1016/j.jep.2007.01.007

Cited by 21 publications

(11 citation statements)

References 23 publications

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“…Therefore, the identification of treatments with anti-apoptotic and anti-autophagic effects is important for protection of the heart from I/R injury. The investigation of traditional medicines as a potential treatment option in I/R injury has received interest due to their wide range of pharmacological effects (15)(16).…”

Section: Introductionmentioning

confidence: 99%

Curcumin inhibits autophagy and apoptosis in hypoxia/reoxygenation-induced myocytes

Huang

Dai

et al. 2015

Molecular Medicine Reports

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Abstract. Primary percutaneous coronary intervention, or thombolytic therapy, provides effective myocardial blood reconstruction in patients with acute myocardial infarction to reduce acute myocardial ischemic injury. However, reperfusion can itself induce cardiomyocyte death, termed myocardial reperfusion injury (I/R). Hypoxia/reoxygenation (H/R) induces apoptosis and excessive autophagy among cardiomyocytes, leading to cell death. The present study investigated the effect of curcumin, a natural extract from Curcuma longa, on these two cellular processes in H9c2 myocytes. The levels of cellular apoptosis and autophagy were found to be upregulated in the H9c2 myocytes during H/R and were correlated with a reduced rate of cell survival. However, curcumin significantly suppressed the levels of H/R-induced apoptosis (expression of annexin V) and autophagy (LC3B-II/LC3B-I ratio) in the H9c2 myocytes and promoted cell survival. Additionally, the expression of B-cell lymphoma 2 (Bcl-2) was significantly downregulated and the expression levels of Bcl-2-associated X protein, beclin-1, Bcl-2/adenovirus E1B 19 kDa interacting protein 3 (BNIP3) and silent information regulation 1 (SIRT1) were significantly upregulated in myocytes following H/R injury. These effects on the expression of these proteins were reversed by curcumin treatment. These findings suggested that the protective effect of curcumin against H/R injury in the H9c2 myocytes was through the inhibition of apoptosis and autophagy by inducing the expression of Bcl-2 and inhibiting the expression levels of Bax, beclin-1, BNIP3 and SIRT1. Therefore, curcumin may offer a promising therapeutic approach for the treatment of cardiomyocyte injury resulting from I/R.

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Section: Introductionmentioning

confidence: 99%

Curcumin inhibits autophagy and apoptosis in hypoxia/reoxygenation-induced myocytes

Huang

Dai

et al. 2015

Molecular Medicine Reports

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“…The rat heart is by far the best characterized, as well as being the most frequently used, organ for complex perfusion preparations such as working and blood-perfused hearts. 45) In terms of handling ease, the rat has a great advantage over smaller hearts, such as those of the mouse, in which intraventricular pressure recordings are more difficult. Under these ischemic conditions, myocardial oxidative metabolism is suppressed and glycolysis becomes an important source of ATP generation.…”

Section: Effects Of Gs On Cardiac Outputmentioning

confidence: 99%

Protective Roles of Ginseng Saponin in Cardiac Ischemia and Reperfusion Injury

Kim¹

2009

Journal of Ginseng Research

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“…It has been reported that ‘Zhiqiao’, ‘Zhishi’, ‘Chenpi’, ‘Qingpi’, ‘Huajuhong’, and ‘Foshou’ all contain similar constituents, such as flavonoids , coumarins , volatile oil , alkaloids , etc. These constituents are proved in previous studies to possess notable anti‐inflammatory , anti‐oxidation , gastric mucosal protective effects to prevent cardiovascular disease , and so on. As a result, they considered as important active ingredients in MMCG.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous quantitative analysis of nine constituents in six Chinese medicinal materials from Citrus genus by high‐performance liquid chromatography and high‐resolution mass spectrometry combined with chemometric methods

Tian

Sun

et al. 2019

J of Separation Science

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In this study, we aim to determine the chemical constituents of six Chinese medicinal materials from the Citrus genus using high‐performance liquid chromatography and high‐resolution mass spectrometry. Eight flavonoids and one coumarin were identified and further quantified as marker substances by high‐performance liquid chromatography method. The separation was performed on an Agilent TC‐C18 column with 0.1% formic acid and acetonitrile as the mobile phase under gradient elution. The analytical method was fully validated in terms of linearity, sensitivity, intra‐ and inter‐day precision and repeatability, limit of detection, limit of quantitation, and recovery. It was subsequently applied to evaluate the quality of 103 batches of the Chinese medicinal materials from the Citrus genus. In addition, the principal constituent analysis was used to compare the samples of different species from the Citrus genus leading to successful classification of the samples in accordance with their origins. It was found that the contents of nine constituents varied greatly in different ripening stages and varieties of the samples from the Citrus genus. In addition, neoeriocitrin and 5,7‐dimethoxycoumarin were determined as two unique constituents of ‘Zhiqiao’ and ‘Foshou’, respectively. In conclusion, this study provides a chemical basis for quality control of Chinese medicinal materials from the Citrus genus.

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Anti-ischemic effect of Aurantii Fructus on contractile dysfunction of ischemic and reperfused rat heart

Cited by 21 publications

References 23 publications

Curcumin inhibits autophagy and apoptosis in hypoxia/reoxygenation-induced myocytes

Curcumin inhibits autophagy and apoptosis in hypoxia/reoxygenation-induced myocytes

Protective Roles of Ginseng Saponin in Cardiac Ischemia and Reperfusion Injury

Simultaneous quantitative analysis of nine constituents in six Chinese medicinal materials from Citrus genus by high‐performance liquid chromatography and high‐resolution mass spectrometry combined with chemometric methods

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