Anti‐Jo<sup>a</sup>: An Antibody Defining a High‐frequency Erythrocyte Antigen

Jensen, Leila; Scott, Edward P.; Marsh, W. L.; MacIlroy, M.; Rosenfield, Richard E.; Brancato, P; Fay, Ann

doi:10.1111/j.1537-2995.1972.tb04452.x

Cited by 16 publications

(13 citation statements)

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“…The high‐prevalence antigen Jo a 12 was shown to have a phenotypic association with Gy a and Hy antigens because RBCs with either the Gy(a–) phenotype or the Hy– phenotype are also Jo(a–) 13,14 . Another high‐incidence antigen, Jc a , was shown to be associated with Gy a and Hy 15 but later shown not to be a discrete antigen 16,17 …”

Section: Characteristics Of Dombrock As Revealed By Hemagglutinationmentioning

confidence: 99%

Complexities of the Dombrock blood group system revealed

Reid

2005

Transfusion

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The Do(a) antigen was discovered after I began my career in immunohematology and I have been fortunate to be involved in several fascinating discoveries in the Dombrock blood group system. The Do(a) antigen and its antithetical antigen, Do(b), have a prevalence that makes them useful as genetic markers. The paucity of reliable anti-Do(a) and anti-Do(b) has prevented this potential from being realized; however, our ability to type for DO alleles at the DNA level has made it possible to test cohorts from different populations. In 1992, the Dombrock blood group system was expanded to include three phenotypically related antigens, Gy(a), Hy, and Jo(a), when it was discovered that the Gy(a-) phenotype was the null of the Dombrock system. Based on the knowledge that the Dombrock glycoprotein is attached to the RBC membrane via a glycosylphosphatidylinositol linkage and subsequent to the assignment of the corresponding gene to the short arm of chromosome 12, expressed sequence tags from terminally differentiating human erythroid cells were analyzed in silico to identify the DO gene. This allowed determination of the molecular basis of the various Do phenotypes and the realization that DO is identical to the gene encoding a mono-ADP-ribosyltransferase, ART4. No enzymatic activity in RBCs has been demonstrated and the function of this glycoprotein, on the outside surface of RBCs, has yet to be determined. This review is a synthesis of our current knowledge of the Dombrock blood group system.

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Section: Characteristics Of Dombrock As Revealed By Hemagglutinationmentioning

confidence: 99%

Complexities of the Dombrock blood group system revealed

Reid

2005

Transfusion

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“…Anti -Jo a (Joseph) was fi rst described when cells and sera of two African American patients with antibodies to high frequency antigens were found to be mutually compatible [38] , though subsequent genotyping suggests that the eponymous antibody may actually have been anti -Hy [37] . Another example of anti -Jo a was found in an African American sickle cell disease patient [39] , though he was also subsequently found to have an unexpected genotype, being heterozygous for the DO * JO allele and a normal DO * B allele [37] .…”

Section: Gy a ( Do3) And Gy( A−) The Do Null Phenotypementioning

confidence: 99%

“…Do a , Do b , and Jo a are fully expressed on cord red cells [11,12,38,40] . In contrast, it is reported that Gy a and Hy are expressed only weakly on cord cells [27,34] .…”

Section: Development and Distribution Of Dombrock Antigensmentioning

confidence: 99%

Dombrock Blood Group System

Daniels

2013

Human Blood Groups

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“…Anti‐Jo a (Joseph) was first described in 1972 and was discovered when an antibody in the serum of two unrelated black individuals was mutually compatible 1 . This antibody was incompatible with all other RBCs tested, and the Jo a antigen was described as an independent high‐incidence antigen.…”

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Evidence that Hy– RBCs express weak Jo^a antigen

Scofield¹,

Miller²,

Storry³

et al. 2004

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BACKGROUND: RBCs of the Hy– phenotype have, in the past, been typed as Gy(a+w), Hy–, Jo(a–), and RBCs with the Jo(a–) phenotype type Gy(a+), Hy+w, and Jo(a–). Anti‐Hy and anti‐Joa are difficult to identify mainly because appropriate reagent RBCs are poorly characterized. Historically, anti‐Joa has not reacted with RBCs with either phenotype. This report describes a case of an anti‐Joa that shows Hy– RBCs express some Joa antigen, albeit weakly. CASE REPORT: Anti‐Joa was identified in a serum sample of a 71‐year‐old woman. The antibody reacted 1+ to 2+ by the IAT with all untreated and ficin‐treated panel RBCs and did not react with Gy(a–) RBCs and Jo(a–) RBCs. Unexpectedly, the serum sample reacted weakly with six of eight RBC samples with the Hy– phenotype. The anti‐Joa was adsorbed onto and eluted from Hy– RBCs, indicating the presence of weak Joa antigen. The patient's RBCs typed Gy(a+), Hy+, Jo(a–). DNA studies using PCR‐RFLP analysis showed the patient to be homozygous for the JO allele, which is consistent with the serologically determined Jo(a–) status. CONCLUSION: The DNA and serologic evidence of this case show that Hy– RBCs may express low levels of Joa antigen, which contradicts previously published data concerning the Joa type of Hy– RBCs.

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Anti‐Jo^a: An Antibody Defining a High‐frequency Erythrocyte Antigen

Cited by 16 publications

References 1 publication

Complexities of the Dombrock blood group system revealed

Complexities of the Dombrock blood group system revealed

Dombrock Blood Group System

Evidence that Hy– RBCs express weak Jo^a antigen

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Anti‐Joa: An Antibody Defining a High‐frequency Erythrocyte Antigen

Cited by 16 publications

References 1 publication

Complexities of the Dombrock blood group system revealed

Complexities of the Dombrock blood group system revealed

Dombrock Blood Group System

Evidence that Hy– RBCs express weak Joa antigen

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Resources

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Anti‐Jo^a: An Antibody Defining a High‐frequency Erythrocyte Antigen

Evidence that Hy– RBCs express weak Jo^a antigen