Anti-leukemic and topoisomerase I inhibitory effect of Mansonone E isolated from Ulmus davidiana

Lee, Keyong Ho; Cho, Choa Hyoung; Rhee, Kyu-Nam

doi:10.5897/jmpr11.1757

Cited by 2 publications

(4 citation statements)

References 17 publications

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“…Mansonone is a naphthoquinone-containing compound, isolated from Mansonia gagei Drumm, a Thai traditional plant which is locally used as an antidepressant, antiemetic, cardiac stimulant and refreshment agent (20,74). It was reported that mansonone E and F exhibited anticancer effect against various cancer cell lines including melanoma (A375-S2), cervical cancer (HeLa), breast cancer (MCF-7), lymphoma (U937), cervical cancer (HeLa), colorectal cancer (HT-29), oral cavity cancer ( KB) and leukemia cell lines (HL60, K562, THP-1 and U937) (23)(24)(25). However, the anticancer effect of mansonone G (MG) against CRC cells has not been reported.…”

Section: Chapter V Discussion and Conclusionmentioning

confidence: 99%

“…It is commonly known that caspase-mediated apoptotic cell death is accomplished through the cleavage of several key proteins required for cellular functions and cell survival. PARP is one of the several substrates of caspases (25)(26)(27).…”

Section: Chapter V Discussion and Conclusionmentioning

confidence: 99%

“…4 µM, respectively (24). Furthermore, toxicity of mansonone E, extracted from the root bark of Ulmus davidiana, against various human leukemia cell lines, including HL60, K562, THP-1 and U937 has been found (25).…”

Section: List Of Abbreviationsmentioning

confidence: 99%

“…4 µM, respectively(24). Furthermore, cytotoxicity of mansonone E, extracted from the root bark of Ulmus davidiana, has been found against various human leukemia cell lines, including HL60, K562, THP-1 and U937(25).In 2003, Tiew et al extracted several mansonones including mansonone C, E, N, O, P, H, G from the heartwood of Mansonia gagei Drumm and found that mansonone G (MG) is a major compound of the extract. The extraction yield was approximately 5 g (75).…”

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Anticancer effects of mansonone G derivative on human colorectal cancer cells

Chanvijit

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Mansonone G (MG), 1,2-naphthoquinone, isolated from the heartwood of�Mansonia gagei�Drumm (Chan-Cha-Mod), exhibited several pharmacological effects including anti-bacterial, anti-estrogenic and anti-adipogenic effects. However, anticancer activity of MG and its derivatives on colorectal cancer (CRC) has never been investigated. Therefore, the objective of this study was to investigate the cytotoxic effect of MG and its derivatives and to determine the mechanism(s) underlying cytotoxicity of the most potent MG derivative on two CRC cell lines, HCT-116 cells carrying p53 wild-type and HT-29 cells carrying p53 mutant. In the present study, MG and its derivatives could inhibit viability of HCT-116 and HT-29 cells in a concentration-dependent manner. Of all MG and its derivatives, G07 was the most potent cytotoxic agent toward the�cancer cells and less toxic to normal cells, PCS201-010 and CRL-1790. Mechanistic studies revealed that G07 could induce apoptosis through ROS generation in both HCT-116 and HT-29 cells and this effect was abolished by�N-acetyl cysteine (NAC). Western blot analysis revealed that G07 downregulated the expression of Bcl-2 and Bcl-xl proteins in both cells and upregulated the expression of Bak protein in HT-29 cells. Moreover, G07 downregulated AKT signaling pathway and modulated ERK1/2 signaling pathway by inhibiting ERK1/2 phosphorylation in HCT-116 cells and activating ERK1/2 phosphorylation in HT-29 cells. Taken together, the present study demonstrated�that G07 exerted a potent anticancer effect toward human colorectal cancer cells which was associated with induction of apoptosis, generation of ROS and modulation of ERK1/2 and AKT signaling pathways, suggesting that G07 is a promising compound for further development as an anticancer agent in CRC treatment.

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Section: Chapter V Discussion and Conclusionmentioning

confidence: 99%

Section: Chapter V Discussion and Conclusionmentioning

confidence: 99%

Section: List Of Abbreviationsmentioning

confidence: 99%

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Anticancer effects of mansonone G derivative on human colorectal cancer cells

Chanvijit

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LC/ESI-MS/MS profiling of Ulmus parvifolia extracts and evaluation of its anti-inflammatory, cytotoxic, and antioxidant activities

Mina

Melek

Adeeb

et al. 2016

Zeitschrift Für Naturforschung C

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In this study, a comparative liquid chromatography/mass spectroscopy (LC/ESI-MS/MS) profiling of different fractions of Ulmus parvifolia leaves and stems was performed. Identification of compounds was based on comparing the mass spectrometric information obtained including m/z values and individual compound fragmentation pattern to tandem mass spectral library search and literature data. Eleven compounds were tentatively identified in the different analyzed fractions. One of the major constituents of this plant was isolated and identified as Icariside E4 [dihydro-dehydro-diconiferyl alcohol-4-O-α-L-rhamnopyranoside] (5). The evaluation of anti-inflammatory activity of the total methanolic extract using nitric oxide inhibition on LPS-stimulated RAW 264.7 cells model strong anti-inflammatory activity with 17.5% inhibition of nitric oxide production versus 10% inhibition for dexamethasone. The cytotoxic activity of the methanolic extract and Icariside E4 was evaluated against four types of human cell lines using MTT assay. Icariside E4 showed cytotoxic effect against Hep-G2, MCF-7, and CACO-2 cell lines compared to a negligible activity for the total extract. The same extract showed a moderate antioxidant activity with SC50=362.5 μg/mL.

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Anti-leukemic and topoisomerase I inhibitory effect of Mansonone E isolated from Ulmus davidiana

Cited by 2 publications

References 17 publications

Anticancer effects of mansonone G derivative on human colorectal cancer cells

Anticancer effects of mansonone G derivative on human colorectal cancer cells

LC/ESI-MS/MS profiling of Ulmus parvifolia extracts and evaluation of its anti-inflammatory, cytotoxic, and antioxidant activities

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