Anti-MAG IgM penetration into myelinated fibers correlates with the extent of myelin widening

Ritz, Marie‐Françoise; Erne, Beat; Ferracin, Fabrizia; Vital, Anne; Vital, C; Steck, Andreas

doi:10.1002/(sici)1097-4598(199908)22:8<1030::aid-mus4>3.0.co;2-h

Cited by 75 publications

(47 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Direct immunohistochemical studies reveal the presence of deposits of IgM mostly in the paranodal regions, the SchmidtLantermann incisure, and the basal membrane. A close correlation between the number of widely spaced myelin lamellae and the deposition of IgM has been demonstrated [25]. All these data support the pathogenic role of anti-MAG antibodies in this neuropathy.…”

Section: Neuropathies With Igm Monoclonal Gammopathiessupporting

confidence: 60%

Auto-antibody tests in peripheral neuropathies: pros and cons

Steck¹

2000

Journal of Neurology

View full text Add to dashboard Cite

Most inflammatory neuropathies, both acute and chronic, probably result from an immune attack against antigens of the peripheral nervous system. Specific antibodies in serum that react with the peripheral nervous system have been described in a number of inflammatory neuropathies. We review the pathophysiological significance of auto-antibodies and discuss their use for the diagnosis of patients with peripheral neuropathy.

show abstract

Section: Neuropathies With Igm Monoclonal Gammopathiessupporting

confidence: 60%

Auto-antibody tests in peripheral neuropathies: pros and cons

Steck¹

2000

Journal of Neurology

View full text Add to dashboard Cite

show abstract

“…A close correlation between the number of widely spaced myelin lamellae and the deposition of IgM has been demonstrated [16]. Sulfatide is a common glycolipid in peripheral nerve myelin and dorsal root ganglia [12,14].…”

Section: Discussionmentioning

confidence: 95%

Polyneuropathy attributes: a comparison between patients with anti-MAG and anti-sulfatide antibodies

Erb

Ferracin

Fuhr

et al. 2000

Journal of Neurology

View full text Add to dashboard Cite

Thirty-two patients with a peripheral neuropathy and paraproteinemia were tested for IgM antibodies against myelin-associated protein (MAG) and sulfatide by means of enzyme-linked immunosorbent assay. Nine patients (28 %) had increased anti-sulfatide IgM antibodies and showed a chronic, slowly progressive, distally pronounced, and symmetric polyneuropathy with sensory to sensory-motor impairment, ataxia, hyporeflexia, and axonal involvement in electrophysiological studies. Ten patients (31 %) with increased anti-MAG antibodies had a similar, homogeneous polyneuropathy syndrome but presented with demyelinating features. A weak cross-reactivity between anti-MAG and anti-sulfatide antibodies was present in only three patients. In conclusion, although the two neuropathy groups clearly differed in their electrophysiological features, their clinical presentation was rather similar.

show abstract

“…Many reports have confirmed monoclonal proteins localized in the myelin sheaths [28,[31][32][33][34]35]. Immunohistochemical analysis of sural nerve cross-sections reveals anti-MAG IgM antibody deposits on both large and small myelinated nerve fibers derived from patients with anti-MAG neuropathy (Fig.…”

Section: Pathologymentioning

confidence: 82%

“…IgM antibodies are not seen on the periaxonal membrane of longitudinal sections. Confocal microscopy reveals colocalization of anti-IgM antibodies and complement C3d, possibly activated by the complement pathway [34].…”

Section: Pathologymentioning

confidence: 97%