Anti-melanogenic effects of resorcinol are mediated by suppression of cAMP signaling and activation of p38 MAPK signaling

Kang, Mingyeong; Park, See‐Hyoung; Oh, Sae Woong; Lee, Seung Eun; Yoo, Ju Ah; Nho, Youn Hwa; Lee, Sukyeon; Han, Byung Seok; Cho, Jae Youl; Lee, Jongsung

doi:10.1080/09168451.2018.1459176

Cited by 21 publications

(17 citation statements)

References 35 publications

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“…Recently, our group demonstrated the anti-melanogenic mechanisms of resorcinol, which is one of the phenolic components of argan oil 36 . Similar to beauvericin, resorcinol suppressed the enzymatic activity of tyrosinase.…”

Section: Discussionmentioning

confidence: 99%

“…The real-time RT-PCR analysis was conducted using TaqMan probes (Applied Biosystems) including Tyrosinase (ID: Mm00495818_m1), MITF (ID: Mm01182484_m1), TRP-1 (ID: Mm01268471_m1), TRP-2 (ID: Mm01225584_m1), hypoxanthine-guanine phosphoribosyltransferase (HPRT) (Mm00446966_m1), 18S (Mm04277571_s1), and GAPDH (ID: Mm99999915_g1). The PCR reaction was done with parameters as follows: 50 °C for 2 min, 60 °C for 30 min, and 95 °C for 5 min, and then 45 cycles of 94 °C for 20 s and 60 °C for 1 min as described previously 36 . The PCR results were normalized to the expression level of three housekeeping genes ( GAPDH , 18S and HPRT ) using ABI sequence detector software version 2.0 (Applied Biosystems).…”

Section: Methodsmentioning

confidence: 99%

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Beauvericin inhibits melanogenesis by regulating cAMP/PKA/CREB and LXR-α/p38 MAPK–mediated pathways

Lee

Park

et al. 2018

Sci Rep

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Melanogenesis is the process of production of melanin pigments that are responsible for the colors of skin, eye, and hair and provide protection from ultraviolet radiation. However, excessive levels of melanin formation cause hyperpigmentation disorders such as freckles, melasma, and age spots. Liver X receptors (LXR) are nuclear oxysterol receptors belonging to the family of ligand-activated transcription factors and physiological regulators of lipid and cholesterol metabolism. In the skin, activation of LXRs stimulates differentiation of keratinocytes and augments lipid synthesis in sebocytes. However, the function of LXRs in melanogenesis has not been clearly elucidated. In addition, although beauvericin, a well-known mycotoxin primarily isolated from several fungi, has various biological properties, its involvement in melanogenesis has not been reported. Therefore, in this study, we examined the effects of beauvericin on melanogenesis and its molecular mechanisms. Beauvericin decreased melanin content and tyrosinase activity without any cytotoxicity. Beauvericin also reduced protein levels of MITF, tyrosinase, TRP1, and TRP2. In addition, beauvericin suppressed cAMP-PKA-CREB signaling and upregulated expression of LXR-α, resulting in the suppression of p38 MAPK. Our results indicate that beauvericin attenuates melanogenesis by regulating both cAMP/PKA/CREB and LXR-α/p38 MAPK pathways, consequently leading to a reduction of melanin levels.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Beauvericin inhibits melanogenesis by regulating cAMP/PKA/CREB and LXR-α/p38 MAPK–mediated pathways

Lee

Park

et al. 2018

Sci Rep

Self Cite

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“…As an example, it has been reported that both ferulic and caffeic acid inhibited melanin production in B16 melanoma cells, but ferulic acid reduced tyrosinase activity by directly binding to the enzyme, whereas no binding was observed in the case of caffeic acid [177]. Apart from the direct inhibition of tyrosinase activity, the anti-melanogenic activity of resorcinol in B16F10 cells has been attributed to the inhibition of cAMP signaling and activation of p38 MAPK [179]. The same applies e.g., to moracin J [181], 4,5-dicaffeoylquinic acid [183], chrysin [187], casuarictin [178], and synthetic compounds [135,136,153,197], which have been reported to both inhibit intracellular tyrosinase activity and regulate melanogenesis-related protein expression.…”

Section: Human and Animal Tyrosinase Phenolic Inhibitorsmentioning

confidence: 99%

Natural and Bioinspired Phenolic Compounds as Tyrosinase Inhibitors for the Treatment of Skin Hyperpigmentation: Recent Advances

2019

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One of the most common approaches for control of skin pigmentation involves the inhibition of tyrosinase, a copper-containing enzyme which catalyzes the key steps of melanogenesis. This review focuses on the tyrosinase inhibition properties of a series of natural and synthetic, bioinspired phenolic compounds that have appeared in the literature in the last five years. Both mushroom and human tyrosinase inhibitors have been considered. Among the first class, flavonoids, in particular chalcones, occupy a prominent role as natural inhibitors, followed by hydroxystilbenes (mainly resveratrol derivatives). A series of more complex phenolic compounds from a variety of sources, first of all belonging to the Moraceae family, have also been described as potent tyrosinase inhibitors. As to the synthetic compounds, hydroxycinnamic acids and chalcones again appear as the most exploited scaffolds. Several inhibition mechanisms have been reported for the described inhibitors, pointing to copper chelating and/or hydrophobic moieties as key structural requirements to achieve good inhibition properties. Emerging trends in the search for novel skin depigmenting agents, including the development of assays that could distinguish between inhibitors and potentially toxic substrates of the enzyme as well as of formulations aimed at improving the bioavailability and hence the effectiveness of well-known inhibitors, have also been addressed.

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“…The melanin-producing enzyme tyrosinase contributes vitally to the rate-limiting step of the process through which melanin is produced. Therefore, pigmentation disorders are commonly treated and skin brightening achieved by inhibiting or downregulating tyrosinase activity [17,18].…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Antioxidants, Whitening and Antiaging Properties of Rice Protein Hydrolysates

Chen

Dai²,

Chen

et al. 2021

Molecules

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Plant-derived protein hydrolysates have potential applications in nutrition. Rice protein hydrolysates (RPHs), an excellent source of proteins, have attracted attention for the development of cosmeceuticals. However, few studies have reported the potential application of RPH in analysis, and this study examined their antioxidant activities and the inhibitory activities of skin aging enzymes. The results indicated that the total phenolic and flavonoid concentrations were 2.06 ± 0.13 mg gallic acid equivalent/g RPHs and 25.96 ± 0.52 µg quercetin equivalent/g RPHs, respectively. RPHs demonstrated dose-dependent activity for scavenging free radicals from 1,1-diphenyl-2-picrylhydrazyl [half-maximal inhibitory concentration (IC50) = 42.58 ± 2.1 mg/g RPHs] and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (IC50 = 2.11 ± 0.88 mg/g RPHs), dose-dependent reduction capacity (6.95 ± 1.40 mg vitamin C equivalent/g RPHs) and oxygen radical absorbance capacity (473 µmol Trolox equivalent/g RPHs). The concentrations of the RPH solution required to achieve 50% inhibition of hyaluronidase and tyrosinase activities were determined to be 8.91 and 107.6 mg/mL, respectively. This study demonstrated that RPHs have antioxidant, antihyaluronidase, and antityrosinase activities for future cosmetic applications.

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Anti-melanogenic effects of resorcinol are mediated by suppression of cAMP signaling and activation of p38 MAPK signaling

Cited by 21 publications

References 35 publications

Beauvericin inhibits melanogenesis by regulating cAMP/PKA/CREB and LXR-α/p38 MAPK–mediated pathways

Beauvericin inhibits melanogenesis by regulating cAMP/PKA/CREB and LXR-α/p38 MAPK–mediated pathways

Natural and Bioinspired Phenolic Compounds as Tyrosinase Inhibitors for the Treatment of Skin Hyperpigmentation: Recent Advances

Evaluating the Antioxidants, Whitening and Antiaging Properties of Rice Protein Hydrolysates

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