Anti-Metalotoxic Properties of Kelakai (Stenochlaena Palustris) Leaves Extract Against Cadmium-Induced Liver Tissue Damage

Biworo, Agung; Azizi, Nurul Ainun; Padelia, Rizki; Raharja, Muhammad Andino; Azima, Ozanata; Suhartono, Eko

doi:10.22159/ajpcr.2018.v11s3.30028

Cited by 6 publications

(3 citation statements)

References 16 publications

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“…The measured absorbance at specific wavenumbers indicates changes in the DNA and protein composition in the saliva of these newborns, which can be linked to an inflammatory process. This finding is consistent with that of a previous study showing protein damage in neonatal sepsis via the oxidative stress pathway [ 68 ].…”

Section: Shining a Light On Saliva-based Diagnosis: Exploring The App...supporting

confidence: 94%

Unlocking the Diagnostic Potential of Saliva: A Comprehensive Review of Infrared Spectroscopy and Its Applications in Salivary Analysis

Delrue

Bruyne

Speeckaert

2023

JPM

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Infrared (IR) spectroscopy is a noninvasive and rapid analytical technique that provides information on the chemical composition, structure, and conformation of biomolecules in saliva. This technique has been widely used to analyze salivary biomolecules, owing to its label-free advantages. Saliva contains a complex mixture of biomolecules including water, electrolytes, lipids, carbohydrates, proteins, and nucleic acids which are potential biomarkers for several diseases. IR spectroscopy has shown great promise for the diagnosis and monitoring of diseases such as dental caries, periodontitis, infectious diseases, cancer, diabetes mellitus, and chronic kidney disease, as well as for drug monitoring. Recent advancements in IR spectroscopy, such as Fourier-transform infrared (FTIR) spectroscopy and attenuated total reflectance (ATR) spectroscopy, have further enhanced its utility in salivary analysis. FTIR spectroscopy enables the collection of a complete IR spectrum of the sample, whereas ATR spectroscopy enables the analysis of samples in their native form, without the need for sample preparation. With the development of standardized protocols for sample collection and analysis and further advancements in IR spectroscopy, the potential for salivary diagnostics using IR spectroscopy is vast.

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Section: Shining a Light On Saliva-based Diagnosis: Exploring The App...supporting

confidence: 94%

Unlocking the Diagnostic Potential of Saliva: A Comprehensive Review of Infrared Spectroscopy and Its Applications in Salivary Analysis

Delrue

Bruyne

Speeckaert

2023

JPM

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“…According to Sholihah et al [36], the addition of Kalakai also positively increases the iron content of baby porridge. Moreover, Kalakai extract was proven to have high average amount of antioxidant activity compare with vitamin C [37], inhibitory effect against Cdinduced glycation and fructation in vitro [38],and also anti-metalotoxic properties [39].…”

Section: Resultsmentioning

confidence: 99%

Effectiveness of the Addition of Kelakai (Stenochlaena palustris) Extracts in Commercial Pellet as Immunostimulant for Snakehead (Channa striata)

2020

International Journal of Innovative Studies in Aquatic Biology

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This study was aimed at determining the best performance of the addition of Kelakai (Stenochlaena palustris) in commercial pellets as immunostimulant to increase the Snakehead's immune system. Sampling, extraction and measurement were carried out in the Wet Laboratory Faculty of Marine and Fisheries ULM and related institutions. A total of 240 individuals of Snakehead fingerlings (15-25 cm total length and 25-100 g weight) subjected to different feeding levels were investigated in 12 circle containers. A complete random design was used as a research method with four treatments and three repetitions. Treatment A: 0 ml/kg of pellet (control), treatment B: 50 ml/kg, treatment C: 100 ml/kg, and treatment D: 150 ml/kg. The results showed that the survival rate of Snakehead samples reared in indoor containers was 100% for all treatments.

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“…South Kalimantan is a province that has 103.556 ha of wetland and has a biodiversity that is potential to be developed for medicines. Some wetland plants have proven to be beneficial, for example the kelakai (Stenochlaena palustris) uses are used for antimetalotoxic, antiglycation, antioxidant, and protective skin from exposure to UV radiation [1][2][3]. In addition, the pasak bumi (Eurycoma Longifolia Jack.)…”

Section: Introductionmentioning

confidence: 99%

Molecular docking studies of 4-ethyl-2-metoxyphenol and 1,3-cyclopentanedione compounds from gemor (Nothaphoebe coriacea) with glucagon like-peptide-1 (GLP-1) receptor

Suhartono

Biworo

Santosa³

et al. 2022

IOP Conf. Ser.: Earth Environ. Sci.

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Gemor (Nothaphoebe coriacea) is a plant that grows in wetland forests. Many studies have revealed the potential of this plant for health and medicine, among others as an antioxidant, anti-inflammatory, antidiabetic, and others. However, the mechanism is unknown or not yet discovered. Previous studies have shown that gemor bark contains active compounds. One of them is 4-ethyl-2-metoxyphenol (PubChem ID 62465) and 1,3-cyclo pentanedione (PubChem CID 77466) compounds. This research will prove that 2 compounds act as antidiabetic by influencing Glucagon like-Peptide-1 (GLP-1) Receptor. Molecular docking was carried out on 2 these compounds. The protein is taken from RCSB PDB (4ZGM). Ligand and protein preparation, analyzed and visualized docking results were carried out with the Chimera 1.14. Molecular docking using SWISSDOCK. The results show that the 4-ethyl-2-methoxyphenol compound can be bound by 6 residues (SER 84, CYS 85, TRP 87, ALA 92, VAL 95, and Pro 96); 1,3-cyclopentanedione bind by 7 residues (GLY 45, CYS 46, TYR 42, SER 49, CYS 71, VAL 83 and PRO 73). Gibbs energy for 4-Ethyl-2-methoxyphenol and 1,3-Cyclopentanedione, against GLP-1 Receptor each -6.10 kcal/mol and -5.37 kcal/mol. The conclusion is that 4-Ethyl-2-methoxyphenol and 1,3-Cyclopentanedione compound has the potential as an antidiabetic by binding mechanism with residues of GLP-1 receptor.

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Anti-Metalotoxic Properties of Kelakai (Stenochlaena Palustris) Leaves Extract Against Cadmium-Induced Liver Tissue Damage

Cited by 6 publications

References 16 publications

Unlocking the Diagnostic Potential of Saliva: A Comprehensive Review of Infrared Spectroscopy and Its Applications in Salivary Analysis

Unlocking the Diagnostic Potential of Saliva: A Comprehensive Review of Infrared Spectroscopy and Its Applications in Salivary Analysis

Effectiveness of the Addition of Kelakai (Stenochlaena palustris) Extracts in Commercial Pellet as Immunostimulant for Snakehead (Channa striata)

Molecular docking studies of 4-ethyl-2-metoxyphenol and 1,3-cyclopentanedione compounds from gemor (Nothaphoebe coriacea) with glucagon like-peptide-1 (GLP-1) receptor

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