Anti‐Mitotic Spindle Apparatus Antoantibodies: Prevalence and Disease Association in Chinese Population

Xi, Qian; Wu, Yongkang; Li, Lixin; Cai, Bei; Zhang, Junlong; Yang, Bin; Wang, Lanlan

doi:10.1002/jcla.21925

Cited by 6 publications

(5 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found a prevalence of 0.46% for the NuMA pattern compared with 0.047% in a Chinese study [ 24 ] and 0.77% in a European cohort, [ 3 ] indicating evident geographical and racial/ethnic variations, as shown for other ANA patterns. [ 25 , 26 ]…”

Section: Discussionmentioning

confidence: 53%

Uncommon patterns of antinuclear antibodies recognizing mitotic spindle apparatus antigens and clinical associations

Betancur¹,

Londoño²,

Estrada³

et al. 2018

Medicine

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 53%

Uncommon patterns of antinuclear antibodies recognizing mitotic spindle apparatus antigens and clinical associations

Betancur¹,

Londoño²,

Estrada³

et al. 2018

Medicine

View full text Add to dashboard Cite

show abstract

“…One of the main molecular targets of anti-MSA antibodies, a rare type of anti-nuclear antibodies (ANA), is KIF11, also known as HsEg5. Anti-MSA antibodies have been reported in connective tissue diseases, systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA), but also in vasculitis [30][31][32]. While the MSA pattern is usually rare, sometimes it represents the only serological marker for patients that are negative for other types of ANA [33].…”

Section: Discussionmentioning

confidence: 99%

Autoantibody Profiling and Anti-Kinesin Reactivity in ANCA-Associated Vasculitis

Mescia,

Bayati,

Brouwer

et al. 2023

IJMS

View full text Add to dashboard Cite

ANCA-associated vasculitides (AAV) are rare autoimmune diseases causing inflammation and damage to small blood vessels. New autoantibody biomarkers are needed to improve the diagnosis and treatment of AAV patients. In this study, we aimed to profile the autoantibody repertoire of AAV patients using in-house developed antigen arrays to identify previously unreported antibodies linked to the disease per se, clinical subgroups, or clinical activity. A total of 1743 protein fragments representing 1561 unique proteins were screened in 229 serum samples collected from 137 AAV patients at presentation, remission, and relapse. Additionally, serum samples from healthy individuals and patients with other type of vasculitis and autoimmune-inflammatory conditions were included to evaluate the specificity of the autoantibodies identified in AAV. Autoreactivity against members of the kinesin protein family were identified in AAV patients, healthy volunteers, and disease controls. Anti-KIF4A antibodies were significantly more prevalent in AAV. We also observed possible associations between anti-kinesin antibodies and clinically relevant features within AAV patients. Further verification studies will be needed to confirm these findings.

show abstract

“…Similarly, Xi et al reported that MSA-recognizing autoantibodies were predominantly coupled with CTD, mostly SS, RA, and SLE. 75 The RNP-associated patterns could be indicative of undifferentiated CTD. 74 Results of another study showed that the NuMA pattern was positive in patients with neurofibromatosis and small vessel vasculitis.…”

Section: Extension Of Autoantibody-based Diagnostics With Uncommon Au...mentioning

confidence: 99%

Clinical Significance of Uncommon, Non-Clinical, and Novel Autoantibodies

Shurin,

Wheeler

2024

ITT

View full text Add to dashboard Cite

Autoantibodies are a common mark of autoimmune reaction and their identification in the patients’ serum, cerebrospinal fluid, or tissues is generally believed to represent diagnostic or prognostic biomarkers of autoimmune diseases or autoinflammatory conditions. Traditionally, autoantibody testing is an important part of the clinical examination of suspected patients, and in the absence of reliable T cell tests, characterization of autoantibody responses might be suitable in finding causes of specific autoimmune responses, their strength, and sometimes commencement of autoimmune disease. Autoantibodies are also useful for prognostic stratification in clinically diverse groups of patients if checked repeatedly. Antibody discoveries are continuing, with important consequences for verifying autoimmune mechanisms, diagnostic feasibility, and clinical management. Adding newly identified autoantibody-autoantigen pairs to common clinical laboratory panels should help upgrade and harmonize the identification of systemic autoimmune rheumatic disorders and other autoimmune conditions. Herein, we aim to summarize our current knowledge of uncommon and novel autoantibodies in the context of discussing their validation, diagnostic practicability, and clinical relevance. The regular updates within the field are important and well justified.

show abstract

Anti‐Mitotic Spindle Apparatus Antoantibodies: Prevalence and Disease Association in Chinese Population

Cited by 6 publications

References 30 publications

Uncommon patterns of antinuclear antibodies recognizing mitotic spindle apparatus antigens and clinical associations

Uncommon patterns of antinuclear antibodies recognizing mitotic spindle apparatus antigens and clinical associations

Autoantibody Profiling and Anti-Kinesin Reactivity in ANCA-Associated Vasculitis

Clinical Significance of Uncommon, Non-Clinical, and Novel Autoantibodies

Contact Info

Product

Resources

About