Anti-Müllerian hormone (AMH): a reliable biomarker of oocyte quality in IVF

Lehmann, P.; Vélez, Maria P.; Saumet, Julio; Lapensée, Louise; Jamal, Wael; Bissonnette, François; Phillips, Simon; Kadoch, Isaac-Jacques

doi:10.1007/s10815-014-0193-4

Cited by 49 publications

(35 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To confirm that AMH is a better marker of COH response and IVF outcomes, we compared it with AFC. Our results confirm previously reported findings [24,25,26] that attested that AFC is less effective than AMH in predicting IFV outcomes; AFC was only associated with number of frozen embryos. La Marca et al [27] indicated that AMH has primarily been related to assisted reproduction because of its strong association with oocyte yield after COH.…”

Section: Discussionsupporting

confidence: 92%

AMH and AMHR2 Polymorphisms and AMH Serum Level Can Predict Assisted Reproduction Outcomes: A Cross-Sectional Study

Peluso

Fonseca²,

Gastaldo³

et al. 2015

Cell Physiol Biochem

View full text Add to dashboard Cite

Background: In human assisted reproduction, the ovarian response to exogenous recombinant Follicle-stimulating Hormone (FSH) therapy is variable and difficult to predict. The standard protocol of ovarian hyperstimulation can result in satisfactory response; however, an unsatisfactory response necessitates FSH dose adjustment or results in ovarian hyperstimulation syndrome (OHSS). Polymorphisms in AMH and AMHR2 genes appear to affect hormone biological activities, thus affecting follicle recruitment and development, leading to infertility. We aimed to evaluate AMH and AMHR2 polymorphisms in infertile women, and correlate those findings with AMH, FSH and estradiol serum level response to controlled ovarian hyperstimulation (COH), as well as assisted reproduction outcomes. Methods: A cross-sectional study comprising 186 infertile women that underwent one cycle of high complexity assisted reproductive treatment. Blood samples were collected and a TaqMan assay was used for AMH G146T/rs10407022 and AMHR2 A-482G/rs2002555, A10G/rs11170555, C1749G/rs2071558 and G4952A/rs3741664 genotyping, and FSH, estradiol and AMH levels were measured. The findings were correlated to human reproduction outcomes. Results: AMH rs10407022 and AMHR2 rs2002555 polymorphisms were not associated with hormonal measurements, whereas AMHR2 rs11170555 and rs3741664 were positively associated with AMH, estradiol and FSH levels. The genotype distribution of AMH and AMHR2 genes according to Controlled Ovarian Hyperstimulation did not show a positive association. However, an association with AFC, degree of oocyte maturation (allele G of AMHR2 rs2071558) the number of embryos produced (alleles T and G of AMH rs10407022 and AMHR2 rs2002555, respectively) and frozen embryo (allele G of AMHR2 rs11170555) were found to be statistically associated. Considering COH, serum AMH and AFC were a positive predictor to OHSS. Regarding serum AMH and assisted reproduction outcomes, a positive correlation with all variables studied was found. Comparing AFC and AMH as predictors of human reproduction outcomes, the AFC was less effective than serum AMH. Considering pregnancy rates, no marker was positively associated. Conclusion: AMHR2 polymorphisms were associated with estradiol, AMH and FSH measurements, as well as number and quality of embryos, while AMH polymorphisms was associated with number of embryos produced. Serum AMH was correlated with nearly all variables analyzed in assisted reproductive treatment, demonstrating that it represents a better biomarker of OHSS and human reproduction outcomes compared to AMH and AMHR2 polymorphisms.

show abstract

Section: Discussionsupporting

confidence: 92%

AMH and AMHR2 Polymorphisms and AMH Serum Level Can Predict Assisted Reproduction Outcomes: A Cross-Sectional Study

Peluso

Fonseca²,

Gastaldo³

et al. 2015

Cell Physiol Biochem

View full text Add to dashboard Cite

show abstract

“…Due to the specific population of breast cancer patients and their goal of fertility preservation in that study, embryo cryopreservation was a freeze-all condition performed at the pronuclear stage. Several studies have examined whether AMH levels are associated with successful supernumerary embryo cryopreservation, with some data showing a statistically significant correlation (16)(17)(18) and other data showing no difference (25). The cryopreservation of supernumerary embryos in the aforementioned studies was performed on day 3.…”

Section: Discussionmentioning

confidence: 99%

“…In terms of embryo cryopreservation, AMH has been shown to predict the availability of pronuclear embryos for cryopreservation in breast cancer patients (15). In addition, several studies have found that the AMH level may predict the availability of good-quality supernumerary day-3 embryos for cryopreservation (16)(17)(18). We sought to determine whether the AMH level can predict the availability of good-quality supernumerary blastocysts for cryopreservation.…”

mentioning

confidence: 99%

Antimüllerian hormone as a predictor of good-quality supernumerary blastocyst cryopreservation among women with levels <1 ng/mL versus 1–4 ng/mL

Kavoussi

Odenwald

Boehnlein

et al. 2015

Fertility and Sterility

View full text Add to dashboard Cite

show abstract

“…For example, during ovarian stimulation for IVF, an increase in soluble Fas (sFas) binding to Fas ligand (FasL) in follicular fluid prevents FasL interaction with its cell-surface receptor as a trigger for apoptosis, thereby inhibiting Fas-mediated apoptosis of mural granulosa and cumulus cells (132). In addition, AMH, a TGFbrelated peptide used to predict oocyte yield, but not necessarily oocyte quality (133)(134)(135)(136)(137), diminishes in the growing follicle (138), where it also predicts follicle responsiveness to FSH in normoandrogenic ovulatory women undergoing IVF (139).…”

Section: Proteins and Proteomicsmentioning

confidence: 99%

Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health

Dumesic

Meldrum

Katz‐Jaffe

et al. 2015

Fertility and Sterility

501

314

View full text Add to dashboard Cite

Anti-Müllerian hormone (AMH): a reliable biomarker of oocyte quality in IVF

Cited by 49 publications

References 34 publications

AMH and AMHR2 Polymorphisms and AMH Serum Level Can Predict Assisted Reproduction Outcomes: A Cross-Sectional Study

AMH and AMHR2 Polymorphisms and AMH Serum Level Can Predict Assisted Reproduction Outcomes: A Cross-Sectional Study

Antimüllerian hormone as a predictor of good-quality supernumerary blastocyst cryopreservation among women with levels <1 ng/mL versus 1–4 ng/mL

Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health

Contact Info

Product

Resources

About