Anti-Müllerian hormone and embryo quality as determined by time-lapse imaging

Korkidakis, Ann; Cho, Kristy K; Albert, Arianne; Au, Jason; Mellon, Jill Anne; Dunne, Caitlin

doi:10.23736/s0026-4784.20.04546-3

Cited by 8 publications

(5 citation statements)

References 23 publications

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“…There are contrasting data reported on the role of AMH in predicting embryo quality. While some studies revealed that serum AMH was not significantly associated with morphokinetic embryo quality as assessed by time-lapse imaging ( 58 , 59 ), there were reports that the oocyte-specific AMH concentration in follicular fluid had good prediction on embryonic development and live birth ( 60 , 61 ). It is interesting to further explore the functional relationship of follicular and serum AMH with oocyte competence, embryo euploidy and its role in embryo selection.…”

Section: Initial Observationsmentioning

confidence: 99%

Clinical Application of AMH Measurement in Assisted Reproduction

Nelson

2020

Front. Endocrinol.

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Anti-Müllerian hormone reflects the continuum of the functional ovarian reserve, and as such can predict ovarian response to gonadotropin stimulation and be used to individualize treatment pathways to improve efficacy and safety. However, consistent with other biomarkers and age-based prediction models it has limited ability to predict live birth and should not be used to refuse treatment, but rather to inform counselling and shared decision making. The use of absolute clinical thresholds to stratify patient phenotypes, assess discordance and individualize treatment protocols in non-validated algorithms combined with the lack of standardization of assays may result in inappropriate classification and sub-optimal clinical decision making. We propose that holistic baseline phenotyping, incorporating antral follicle count and other patient characteristics is critical. Treatment decisions driven by validated algorithms that use ovarian reserve biomarkers as continuous measures, reducing the risk of misclassification, are likely to improve overall outcomes for our patients.

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Section: Initial Observationsmentioning

confidence: 99%

Clinical Application of AMH Measurement in Assisted Reproduction

Nelson

2020

Front. Endocrinol.

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“…Our study showed that the level of serum AMH was significantly higher while PRL and Hcy were statistically lower in patients with high-quality embryos compared to those with poor-quality embryos. The role of AMH level as a biomarker of embryo quality remains controversial (23)(24)(25)(26). Most researchers argued that serum AMH concentrations fluctuate for three days after stimulating with standard hormone-based drugs.…”

Section: Discussionmentioning

confidence: 99%

Homocysteine Level Related to Age Is Associated With Embryo Quality in Women Who Had IVF With Diminished Ovarian Reserve

Wang

Han²,

Jiang³

et al. 2022

Front. Reprod. Health

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“…The role of AMH level as a biomarker of embryo quality remains controversial [23][24][25][26]. Most researchers argued that serum AMH concentrations uctuate on three days after stimulating with standard hormonebased drugs.…”

Section: Discussionmentioning

confidence: 99%

Homocysteine Level Related To Age Is Associated With Embryo Quality In IVF Women With Diminished Ovarian Reserve

Wang

Han

Wei

et al. 2022

Preprint

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Background: Diminished ovarian reserve (DOR) contributes significantly to female infertility. Embryo quality affects pregnancy outcome. However, the factors that influence pregnancy outcomes in DOR patients are not well established. In this study, we analyzed the medical records of infertile women with DOR who underwent ART to reveal the possible correlation between clinical characteristics and embryo quality. Methods: A retrospective cohort study was conducted using 3390 medical record data on IVF cycles from Dalian Municipal Women and Children’s Medical Center (Group) from January 2015 to December 2020. The data was divided into poor-quality embryos group and high-quality embryos group according to the embryo status. We summarized the demographic and clinical characteristics (age, infertility years, infertility type, AFC, and BMI), medical history, reproductive hormone parameters (AMH, FSH, LH, PRL, and E2), and carbohydrate and lipid metabolic indexes (CHO, TG, LP, LDL, HDL, FINS, Glucose, and Hcy). To further evaluate the Hcy levels in patients with different embryo quality, we performe subgroup analysis. In order to further evaluate the Hcy levels of patients with different embryo quality, we conducted a subgroup analysis, which was divided into three subgroups: Hcy ≥15, 15> Hcy >8 and Hcy ≤8. A total of 1023patients with DOR were included in this study.Results: Of these, 483 cases were with high-quality embryos (the number of high quality embryo, number≥1), and 540 cases with poor-quality embryos (no high quality embryo, number=0). Demographic characteristics of the two groups were similar. However, the level of serum Hcy was significantly higher in the poor-quality embryo group compared with the high-quality embryo group (P < 0.05). In addition, the levels of serum AMH and PRL were statistically different between the two groups. Patients with serum Hcy ≥ 15 μmol/L were at higher risk of having poor-quality embryos (82.1%) compared to patients with serum Hcy less than 8 μmol/L (43.9%) and at 8~15 μmol/L (48.1%) (c2 =15.859, P < 0.001).Conclusion: The presented study demonstrated that high serum Hcy level is linked to poor-quality embryos. Moreover, Hcy coupled with age might be a sensitive marker for embryo quality after IVF.

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Anti-Müllerian hormone and embryo quality as determined by time-lapse imaging

Cited by 8 publications

References 23 publications

Clinical Application of AMH Measurement in Assisted Reproduction

Clinical Application of AMH Measurement in Assisted Reproduction

Homocysteine Level Related to Age Is Associated With Embryo Quality in Women Who Had IVF With Diminished Ovarian Reserve

Homocysteine Level Related To Age Is Associated With Embryo Quality In IVF Women With Diminished Ovarian Reserve

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