Homocysteine Level Related to Age Is Associated With Embryo Quality in Women Who Had IVF With Diminished Ovarian Reserve

Wang, Haiyan; Han, Aiqing; Jiang, Shiyuan; Cao, Deliang; Jiang, Yangyu; Sun, Lin; Zou, Na; Tao, Shiying; Xue, Xiaoou; Shao, Xiaoliang; Li, Jian

doi:10.3389/frph.2022.886277

Cited by 5 publications

(5 citation statements)

References 35 publications

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“…Our findings are consistent with previous reports that higher levels of serum homocysteine worsen the fertilization rate, although other parameters such as the number of oocysts retrieved and MII oocytes were not associated with the level of homocysteine. Furthermore, a recent retrospective cohort study reported that serum homocysteine levels were statistically lower in patients with high-quality embryos than in those with poor-quality embryos, and only serum homocysteine levels were found to correlate with embryo quality in a logistic regression analysis [39]. Our results were consistent with a statistically significant decrease in AMH levels in the group with higher homocysteine levels; however, there was no association between AMH, homocysteine, and embryo quality.…”

Section: Discussionsupporting

confidence: 85%

Impact of Homocysteine as a Preconceptional Screening Factor for In Vitro Fertilization and Prevention of Miscarriage with Folic Acid Supplementation Following Frozen-Thawed Embryo Transfer: A Hospital-Based Retrospective Cohort Study

Ogawa,

Ota,

Takahashi

et al. 2023

Nutrients

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Homocysteine is an amino acid naturally produced in the body and metabolized via the methionine cycle. High homocysteine levels can increase the risk of infertility and pregnancy complications, such as preeclampsia, preterm delivery, miscarriage, and low birth weight. Preconceptional homocysteine levels may be reduced by taking folic acid supplements to reduce the risk of such complications. This cross-sectional, hospital-based study was conducted to examine the role of homocysteine in 1060 infertile women with a history of IVF/intracytoplasmic sperm injection (ICSI) failure. We analyzed whether folic acid intervention altered homocysteine levels and influenced reproductive outcome. We found that a higher homocysteine level was statistically associated with a lower fertilization rate in patients with a history of IVF/ICSI failure. There was an inverse relationship between homocysteine levels and serum 25(OH)VD, and a trend towards lower anti mullerian hormone in the group with higher homocysteine levels. This is the first interventional study to identify that folic acid supplementation improved pregnancy outcomes following freeze embryo transfer (FET) in women with a history of FET failure by monitoring the reduction in homocysteine levels. Therefore, folic acid supplementation and homocysteine level monitoring may constitute a novel intervention for improving IVF/ICSI pregnancy outcomes.

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Section: Discussionsupporting

confidence: 85%

Impact of Homocysteine as a Preconceptional Screening Factor for In Vitro Fertilization and Prevention of Miscarriage with Folic Acid Supplementation Following Frozen-Thawed Embryo Transfer: A Hospital-Based Retrospective Cohort Study

Ogawa,

Ota,

Takahashi

et al. 2023

Nutrients

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“…One study found that lower homocysteine levels in embryo culture medium were associated with a better chance of pregnancy and better embryo quality [ 45 ]. However, another study found no association between serum homocysteine levels and IVF/ICSI pregnancy outcomes [ 46 ]. Additionally, high homocysteine levels have been identified as a risk factor for unexplained infertility and pregnancy complications such as preeclampsia, preterm delivery, miscarriage, and low birth weight [ 3 ].…”

Section: Reviewmentioning

confidence: 99%

“…Elevated homocysteine levels have been associated with various aspects of infertility, including poor oocyte quality, male infertility due to abnormal sperm, and unexplained infertility in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) [ 43 - 44 ]. Lower follicular fluid homocysteine levels have been associated with a better chance of clinical pregnancy, and homocysteine-lowering agents have shown a favorable impact on the outcome of infertility in cases of unexplained infertility associated with hyperhomocysteinemia [ 45 - 46 ]. Additionally, high homocysteine levels have been identified as a risk factor for pregnancy complications such as preeclampsia, preterm delivery, miscarriage, and low birth weight [ 46 ].…”

Section: Reviewmentioning

confidence: 99%

“…Lower follicular fluid homocysteine levels have been associated with a better chance of clinical pregnancy, and homocysteine-lowering agents have shown a favorable impact on the outcome of infertility in cases of unexplained infertility associated with hyperhomocysteinemia [ 45 - 46 ]. Additionally, high homocysteine levels have been identified as a risk factor for pregnancy complications such as preeclampsia, preterm delivery, miscarriage, and low birth weight [ 46 ]. These findings suggest a potential role for homocysteine in assessing and managing subfertility.…”

Section: Reviewmentioning

confidence: 99%

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Unraveling the Link Between Serum Homocysteine Levels and Nutrient Deficiency in Subfertility: A Comprehensive Review

Shukla,

Shrivastava

2023

Cureus

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Subfertility, a prevalent and emotionally taxing condition affecting couples worldwide, has garnered increasing attention in reproductive health. While its etiology remains multifaceted, emerging research has explored the role of serum homocysteine levels and nutrient deficiencies in influencing subfertility. This comprehensive review synthesizes current knowledge, beginning with an introduction to subfertility and the significance of investigating serum homocysteine levels. It proceeds to elucidate the role of nutrient deficiencies, particularly folate and vitamin B12, in homocysteine metabolism and examines existing research linking homocysteine to subfertility. The review explores potential mechanisms underlying this relationship, addressing the variability in study findings and their contributing factors. Implications for clinical practice, including assessing serum homocysteine levels, nutritional interventions, and personalized medicine, are discussed. Moreover, the review underscores the importance of ongoing research. It offers a call to action for advancing our understanding of subfertility and improving the lives of individuals and couples navigating reproduction challenges.

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“…Типовість визначених змін свідчить про загальний патогенез ускладнень вагітності (передчасне переривання, прееклампсія, затримка росту плода), основна дія яких проявляється у зоні контакту трьох епітеліальних систем -ендотелію маткових судин, судин ворсин та епітелію міжворсинчастого простору [2,7,20,21].…”

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Analysis of perinatal consequences against the background of the proposed treatment complex in pregnant women after the application of assisted reproductive technologies

Vygivska,

Beniuk,

Oleshko

et al. 2023

RHW

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The course of pregnancy that occurs as a result of the application of assisted reproductive technologies is accompanied by numerous complications that affect the indicators of perinatal morbidity and mortality. Nowadays in Ukraine, there is no unified approach to the management of women whose pregnancy occurred as a result of ART application, which determined the direction of this work.The objective: to assess perinatal consequences against the background of the introduction of the proposed treatment complex in women whose pregnancy occurred as a result of the application of assisted reproductive technologies.Materials and methods. 249 pregnant women were examined, which were divided into: group I – 94 women with tubo-peritoneal, group II – 87 women with endocrine and group III – 68 women with male types of infertility. Depending on the prescribed therapy, women of groups I, II and III are divided into: subgroup IA – 49 pregnant women with tubo-peritoneal, subgroup IIA – 48 pregnant women with endocrine, subgroup IIIA – 36 pregnant women with male factor of infertility who received the proposed therapeutic and preventive complex; subgroup IB – 45 pregnant women with tubo-peritoneal, subgroup IIB – 39 pregnant women with endocrine, subgroup IIIB – 32 pregnant women with male factor of infertility, which were observed in accordance with generally accepted standards of obstetric care.Results. Against the background of prescribing the proposed complex, there was a significant decrease in the frequency of threatened miscarriage in women of Group I by 41.6%, in women of Group II by 37.1% (p<0.05). In the second and third trimesters, there was a significant decrease in the number of cases of threatening late spontaneous miscarriages, threatening premature birth, placental dysfunction, preeclampsia, and fetal growth retardation syndrome (p<0.05). A significant indicator of the effectiveness of the proposed treatment complex is a significant increase in the proportion of urgent labor in women of subgroups IA and IIA. Thus, 46 (93.8%) women of subgroup IA and 46 (95.8%) women of subgroup IIA had urgent labor.Assessing the pathological conditions of newborns, it should be noted that in children from women in labor of subgroups who received the proposed complex, respiratory disorders syndrome (p<0.05), intraventricular hemorrhages (p<0.05), hypoxic-ischemic encephalopathy (p<0.05), and cases of antenatal infection (p<0.05) were determined in a significantly smaller number of cases.Conclusions. The effectiveness of the proposed treatment complex and the complex of psychoemotional correction in pregnant women after the use of assisted reproductive technologies is confirmed by a reliably better course of the first, second and third trimesters of pregnancy, a reliably better course of Labor, which was reflected in an increase in cases of urgent labor and a decrease in cases of complications in childbirth, which was reflected in a significant decrease in the number of cesarean sections.Improvement of perinatal consequences against the background of the use of the proposed treatment complex and the complex of psychoemotional correction in newborns from women in labor after the use of assisted reproductive technologies is confirmed by a significantly larger mass of newborns, a significantly smaller number of newborns with low gestational weight, a significantly higher Apgar score, a significantly smaller number of cases of pathological and transient conditions, and a significantly shorter duration of stay of women in labor and newborns in an obstetric hospital, as well as the absence of cases of early neonatal and perinatal mortality among newborns.

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Homocysteine Level Related to Age Is Associated With Embryo Quality in Women Who Had IVF With Diminished Ovarian Reserve

Cited by 5 publications

References 35 publications

Impact of Homocysteine as a Preconceptional Screening Factor for In Vitro Fertilization and Prevention of Miscarriage with Folic Acid Supplementation Following Frozen-Thawed Embryo Transfer: A Hospital-Based Retrospective Cohort Study

Impact of Homocysteine as a Preconceptional Screening Factor for In Vitro Fertilization and Prevention of Miscarriage with Folic Acid Supplementation Following Frozen-Thawed Embryo Transfer: A Hospital-Based Retrospective Cohort Study

Unraveling the Link Between Serum Homocysteine Levels and Nutrient Deficiency in Subfertility: A Comprehensive Review

Analysis of perinatal consequences against the background of the proposed treatment complex in pregnant women after the application of assisted reproductive technologies

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