Anti-Müllerian Hormone and Inhibin-A, but not Inhibin-B or Insulin-Like Peptide-3, may be Used as Surrogates in the Diagnosis of Polycystic Ovary Syndrome in Adolescents: Preliminary Results

Yetim, Aylin; Yetim, Çağcıl; Baş, Firdevs; Erol, Oğuz Bülent; Çığ, Gülnaz; Uçar, Ahmet; Darendelıler, Feyza

doi:10.4274/jcrpe.3253

Cited by 25 publications

(32 citation statements)

References 55 publications

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“…Reduced inhibin βA may serve as a potential diagnostic biomarker for PCOS detection. In contrast, Yetim et al reported that the dimeric inhibin A level in serum of PCOS patients was significantly higher than that in controls [28]. The reasons for the different expression of inhibin βA or dimeric inhibin A in patients with PCOS may be as follows.…”

Section: Discussionmentioning

confidence: 76%

Novel Serum Biomarkers Detected by Protein Array in Polycystic Ovary Syndrome with Low Progesterone Level

Zheng

Zhou

Cui

et al. 2018

Cell Physiol Biochem

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Background/Aims: Polycystic ovary syndrome (PCOS), characterized by female infertility and metabolic abnormalities, is one of the most common endocrine disorders. The etiology of PCOS remains unknown. The comprehensive analysis of protein alterations in PCOS patients is meaningful for identifying diagnostic biomarkers of PCOS. Here, we explored the clinical value of serum proteins as novel biomarkers to detect PCOS with low progesterone level. Methods: A total of 43 patients with PCOS and 30 healthy women were enrolled. Protein array was used to detect the variations of serum proteins between PCOS patients and healthy women. The level of five serum proteins was further confirmed by ELISA and western blot. The human ovarian granulosa cells (KGN) was cultured to examine the underlying mechanism of PCOS. CCK8 assay and western blot were carried out to evaluate the alterations in proliferative ability, TUNEL assay and DAPI staining to detect the apoptosis of KGN cells. Results: Among the 507 proteins, we identified 76 differentially expressed serum proteins (≧1.5 fold), with 40 elevated and 36 decreased proteins. Moreover, 47 proteins were newly reported in PCOS. The alterations in the five significantly decreased proteins (EREG, inhibin βA, IDE, PDGF-D and KNG1) were further confirmed by ELISA and western blot. The level of these proteins were directly associated with the low progesterone, and the expression could be upregulated by progesterone. EREG and inhibin βA also promoted the proliferation and inhibited the apoptosis of ovarian granulosa cells. Conclusion: The study highlights that serum proteins are differentially expressed in PCOS patients and healthy women, and EREG and inhibin βA levels are upregulated by progesterone, which are correlated with ovarian functions. The study suggests that EREG and inhibin βA may be applied as novel potential biomarkers for PCOS with low progesterone level.

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Section: Discussionmentioning

confidence: 76%

Novel Serum Biomarkers Detected by Protein Array in Polycystic Ovary Syndrome with Low Progesterone Level

Zheng

Zhou

Cui

et al. 2018

Cell Physiol Biochem

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“…Mean, Childhood: Lee, Cui, Savas‐Erdeve, Sahin and Korkmaz . Median, Adolescence: Lee, Lashen, Anderson, Pinola, Elchuri, Cui, Hart, Hernandez and Yetim . Mean, Adolescence: Lee, Elchuri, Cui, Akin, Kim, Reinehr and Sophor…”

Section: Resultsmentioning

confidence: 99%

“…Twenty‐five studies reported serum AMH levels between 10 and 18 years Only five studies reported serum inhibin levels, and only three reported AFC in adolescence . Following a transient decrease at puberty as detailed above, a broad consensus across studies show constant levels of serum AMH during adolescence.…”

Section: Resultsmentioning

confidence: 99%

“…Data were included from 13 studies for a pooled estimate. The weighted median for serum AMH from 10 to 18 years was 26.32 pmol/L (3.68 ng/mL) (data pooled from studies by Lee, Lashen, Anderson, Pinola, Elchuri, Cui, Hart, Hernandez and Yetim) with the weighted mean being 31.84 pmol/L (4.46 ng/mL) (data pooled from studies from Lee, Elchuri, Cui, Akin, Kim, Reinehr, and Sophor(Table ). The weighted median for serum inhibin from 10 to 18 years was 53.86 pg/mL (data pooled from studies by Hagen, Lashen, Akar, and Yetim) .…”

Section: Resultsmentioning

confidence: 99%

“…Twenty-five studies reported serum AMH levels between 10 and 18 years [16][17][18][19][20][22][23][24][25]29,31,[34][35][36][37][38][39][40][41][42][43][44][45][46][47][48] Only five studies reported serum inhibin levels, 23,24,37,45,49 and only three reported AFC in adolescence. 23 16 Cui, 20 Lashen, 24 Lem, 27 Korkmaz 12 and Sahin.…”

Section: Adolescencementioning

confidence: 99%

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Biomarkers of ovarian reserve in childhood and adolescence: A systematic review

Bhide

Pundir

Homburg

et al. 2019

Acta Obstet Gynecol Scand

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Introduction Certain medical disorders as well as their management may affect gonadal function. Recent advances in the management of these conditions accompanied by the availability and success of methods of fertility preservation has highlighted the need for assessment of ovarian reserve in childhood and adolescence. Serum anti‐Mullerian hormone (AMH) and antral follicle count are well established markers of ovarian reserve and serum inhibin has also been used. However, literature on reference ranges for ovarian reserve markers in this age‐group is relatively scarce. Thus, our aim was to evaluate published data to estimate reference values of ovarian reserve makers in childhood and adolescence. Material and methods We performed a systematic review of the literature reporting ovarian reserve markers in childhood and adolescence. We included only those studies examining markers of ovarian reserve in the normal healthy population between the ages of 0 and 19 years. PROSPERO registration: CRD42018119064. Results Serum AMH emerged as the most common biomarker assessed. Serum AMH was detectable at birth and, after a transient increase in infancy, increased steadily in childhood. Following a slight decrease at puberty, levels were constant throughout adolescence with a peak in adolescence or early adulthood. The mean serum AMH values during infancy, childhood and adolescence were 10.55, 22.32 and 31.84 pmol/L, respectively. The corresponding median values were 9.85, 24.49 and 26.32 pmol/L. It was not possible to construct age‐specific reference intervals because of methodological heterogeneity, variations in the assay used to measure AMH and differing interval width for age used in included studies. Serum inhibin showed an increase from childhood to adolescence, with median serum inhibin values of 53.86 pg/mL in adolescence. Antral follicle count showed a significant positive correlation with serum AMH and a median value of 30.52 in adolescence. Conclusions We summarize the trends and levels of biomarkers of ovarian reserve from birth until young adulthood. Peak levels of serum AMH are reported in adolescence or early adulthood. We have reported median/mean values for serum AMH in different age‐groups based on data pooled from several studies, which may be used as a reference when evaluating ovarian reserve in childhood and adolescence especially when considering fertility preservation.

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Proteolytic activation of anti-Müllerian hormone is suppressed in adolescent girls

2022

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Anti-Müllerian Hormone and Inhibin-A, but not Inhibin-B or Insulin-Like Peptide-3, may be Used as Surrogates in the Diagnosis of Polycystic Ovary Syndrome in Adolescents: Preliminary Results

Cited by 25 publications

References 55 publications

Novel Serum Biomarkers Detected by Protein Array in Polycystic Ovary Syndrome with Low Progesterone Level

Novel Serum Biomarkers Detected by Protein Array in Polycystic Ovary Syndrome with Low Progesterone Level

Biomarkers of ovarian reserve in childhood and adolescence: A systematic review

Proteolytic activation of anti-Müllerian hormone is suppressed in adolescent girls

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