Anti-Müllerian Hormone as a Diagnostic Marker in Egyptian Infertile Polycystic Ovary Syndrome Females: Correlations with Vitamin D, Total Testosterone, Dyslipidemia and Anthropometric Parameters

Bakeer, Engy M.; Radwan, Rasha Ali; Mandoury, Ahmed El; Rahman, Abdullah Abd El; Maksoud, Sahar Abd El

doi:10.1515/jomb-2017-0068

Cited by 27 publications

(29 citation statements)

References 53 publications

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“…The current systematic review included eighteen cross-sectional studies and six interventional studies assessing the relationship between serum vitamin D levels and serum AMH levels. The cross-sectional studies demonstrated conflicting results, with several studies finding a positive correlation between serum AMH and vitamin D levels [42,46,50,61], while most studies reported largely negative findings [43][44][45]47,49,[51][52][53][54][55][56][57][58][59]. The systematic review and meta-analysis of the interventional studies revealed that vitamin D supplementations affect serum AMH levels but have opposite effects depending on the ovulatory statuses of the women.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, Bednarska-Czerwińska et al [58] reported a negative correlation between AMH and vitamin D concentrations of up to approximately 30 ng/mL, while beyond that concentration, the trend became positive but statistically insignificant. In addition, differences in the population size may also account for negative findings, as some of the studies had small numbers of patients [43,49,[51][52][53][54]56,58] and were not adequately powered to detect small but significant associations between vitamin D and AMH.…”

Section: Discussionmentioning

confidence: 99%

“…There have been other studies that specifically evaluated the relationship between vitamin D and AMH in PCOS women. A study on PCOS women by Bakeer et al [51], which included 53 infertile PCOS women and 17 healthy ovulatory women, similarly showed no significant correlation between 25OH-D and AMH in either the PCOS or control group (r = −0.303). In contrast, in a large study from Hong Kong that included 451 PCOS women and 244 ovulatory women, Wong et al [50] found that serum 25OH-D levels in PCOS women significantly correlated positively with AMH, the AMH/AFC ratio, and other metabolic parameters.…”

Section: Observational Studiesmentioning

confidence: 93%

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The Association between Vitamin D and Anti-Müllerian Hormone: A Systematic Review and Meta-Analysis

et al. 2020

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Accumulating evidence from animal and human studies indicates a role for vitamin D in female reproductive physiology, and numerous clinical studies have suggested its potential benefit for various aspects of human reproduction. Anti-Müllerian hormone (AMH) is an ovarian biomarker that plays an important role in folliculogenesis. It is the most sensitive ovarian reserve marker and is widely used clinically in reproductive medicine. While initial studies have suggested that vitamin D may be associated with ovarian reserve markers, including AMH, evidence has been conflicting. Currently, there is considerable debate in the field whether vitamin D has the capacity to influence ovarian reserve, as indicated by the AMH level. The current systematic review aims to evaluate and summarize the available evidence regarding the relationship between vitamin D and AMH. In total, 18 observational studies and 6 interventional studies were included in this systematic review. Cross-sectional studies have reported largely discrepant findings regarding an association between serum vitamin D and AMH levels, which are likely due to the heterogeneity in study populations, as well as the apparently complex relationship that may exist between vitamin D and AMH. However, meta-analysis of interventional studies performed herein that examined the effects of vitamin D supplementation on serum AMH levels indicates a cause-effect relationship between vitamin D and AMH, the direction of which appears to depend on a woman’s ovulatory status. Serum AMH was significantly decreased following vitamin D supplementation in polycystic ovarian syndrome (PCOS) women (standardized mean difference (SMD) −0.53, 95% CI −0.91 to −0.15, p < 0.007), while it was significantly increased following vitamin D supplementation in ovulatory women without PCOS (SMD 0.49, 95% CI 0.17 to 0.80, p = 0.003). In conclusion, the results of this systematic review demonstrate that the relationship between vitamin D and AMH is a complex one, and large, randomized trials of vitamin D supplementation focusing on different vitamin D status ranges are necessary to gain more insight into the nature of this relationship and the potential benefit of vitamin D to female reproduction in general.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Observational Studiesmentioning

confidence: 93%

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The Association between Vitamin D and Anti-Müllerian Hormone: A Systematic Review and Meta-Analysis

et al. 2020

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“…Polycystic Ovary Syndrome (PCOS) is the most abundant endocrine disorder in females of reproductive age and one of the main causes of infertility with a prevalence of 9–18 % worldwide (1). Reports state that PCOS constitutes a major health issue in Egyptian females (2, 3). According to the Rotterdam consensus in 2003, PCOS can be diagnosed by the occurrence of two of the following criteria: Oligo-and/or anovulation, clinical and/or biochemical features of hyperandrogenism, and polycystic ovaries on performing ultrasound investigations (4).…”

Section: Introductionmentioning

confidence: 99%

Body mass index and C-reactive protein are potential predictors of asthma development in Egyptian polycystic ovary syndrome patients

Nasser¹,

Ezz²,

Abdel-Mageed³

et al. 2019

Journal of Medical Biochemistry

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Summary Background Recent studies suggest asthma prevalence in polycystic ovary syndrome (PCOS) patients. This is the first study to explore asthma prevalence among Egyptian PCOS patients. It highlighted common findings in PCOS and asthma. It investigated whether these findings could serve as potential predictors of asthma. Methods A hundred PCOS patients, sixty asthmatic patients and thirty apparently healthy females of matched age were included. Body mass index (BMI), C-reactive protein (CRP), IL-6, IgE, 25 (OH) vitamin D, testosterone and lipid profile were measured. Results Both PCOS and asthmatics had significantly higher BMI, Total cholesterol (TC), LDL-C, IgE, CRP and IL-6 (P<0.001) and lower 25 (OH) vitamin D levels (P<0.001) compared to controls. Within the PCOS group, 47 patients developed asthma with a significant increase in BMI (P=0.003), CRP and IgE levels (P<0.001) compared to non-asthmatic PCOS. Both asthmatic PCOS and asthmatics expressed elevated BMI, IgE, IL-6 and CRP levels, but with no significant difference between them. Asthmatic PCOS showed significantly higher testosterone and dyslipidemia profile. Multivariate regression revealed that BMI and CRP could predict asthma development within PCOS (OR=1.104, C.I 1.004–1.2 and OR=1, C.I. 1–1.02), respectively. Receiver operating characteristic (ROC) curve showed that BMI and CRP at a cutoff value 28.5 kg/m2 and 117.6 nmol/L respectively could differentiate between asthmatic and non-asthmatic PCOS with sensitivity 63.8 % and specificity 62% for BMI, and sensitivity and specificity of 66% for CRP. Conclusions This study shows that BMI and CRP are predictors of asthma development in Egyptian PCOS.

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“…The INSR gene is located on chromosome 19 and it consists of 22 exons and 21 introns. The exons 17-21 encode the tyrosine kinase domain of the receptor, which is necessary for insulin signal transduction (16). Mutations in these exons can cause insulin resistance and hyperinsulinemia (17,18).…”

Section: Introductionmentioning

confidence: 99%

Rs1799817 in INSR associates with susceptibility to polycystic ovary syndrome

Daghestani¹

2019

Journal of Medical Biochemistry

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Summary Background Insulin and its receptor (INSR) have been implicated in the etiology of the polycystic ovarian syndrome (PCOS). Here, we investigate the association between INSR rs1799817 polymorphism and PCOS in Saudi Arabian women. Methods study group included 126 PCOS women and 118 normo-ovulatory matched controls. The demographic data was recorded, and the plasma levels of glucose, lipids, leptin, E2, LH, FSH, T, SHBG, and insulin were determined. The genotypic and allele frequencies of rs1799817 were evaluated in both PCOS and control group. Polymerase chain reaction (PCR) was used to amplify Exon 17 of the INSR gene, and the amplified products were analyzed by direct sequencing. A single-nucleotide polymorphism (C to T) was found at locus 10923 (His1058) of rs1799817. Results In the PCOS group, the mutant allele T occurs at a significantly higher frequency (0.306) compared to the control group (0.174) (p<0.001). It shows a dominant effect and elevates the relative risk of PCOS even in the heterozygotes (RR=2.82). After stratification of the participants by body mass index, the frequency of T allele was significantly higher in the lean patients with PCOS compared to the lean control. The obese PCOS also had a higher frequency than the obese control, but the difference was not statistically significant. Several parameter values were affected by the INSR genotype, particularly W/H ratio, lipid, insulin and glucose levels and insulin resistance in PCOS patients. Conclusion The INSR gene polymorphism rs1799817 is a susceptibility locus associated with PCOS in Saudis and associated metabolic and hormonal changes, particularly, in the lean PCOS females.

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Anti-Müllerian Hormone as a Diagnostic Marker in Egyptian Infertile Polycystic Ovary Syndrome Females: Correlations with Vitamin D, Total Testosterone, Dyslipidemia and Anthropometric Parameters

Cited by 27 publications

References 53 publications

The Association between Vitamin D and Anti-Müllerian Hormone: A Systematic Review and Meta-Analysis

The Association between Vitamin D and Anti-Müllerian Hormone: A Systematic Review and Meta-Analysis

Body mass index and C-reactive protein are potential predictors of asthma development in Egyptian polycystic ovary syndrome patients

Rs1799817 in INSR associates with susceptibility to polycystic ovary syndrome

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