Anti-nociceptive Activity of Combined Methanol Extract of Edible Fruit Pulps of some Medicinal Plants

Abstract

Hausa in Northern Nigeria as "Kuka", "Goruba", "Magarya" and "Kurna" while their respective English names are baobab, doum palm, jujube/Chinese date and Christ's thorn. People in North East Nigeria consume the fruit of these plants and believed to have nutritional and analgesic benefits. However, there is paucity of scientific data on the medicinal benefit of the edible parts of these plants especially the fruit pulps in their single form or in combination with each other. Scanty literature on the acute toxicity of the different fruit pulps in rodents showed LD50 values of greater than 5000 mg/kg. 12-14 The present study was aimed at determining the acute toxicity and anti-nociceptive activities of a methanol extracted recipe from the edible fruit pulps of A. digitata, H. thebaica, Z. mauritiana and Z. spina-christi plants. Materials and Methods Sample collection The fruit pulps of A. digitata, Z. mauritiana and Z. spina-christi were collected in dried form from Gamboru market,