Anti-nociceptive activity of the aqueous extract of Erythrina velutina leaves

Marchioro, Murilo; Blank, Maria de Fátima Arrigoni; Mourão, Rosa Helena Veras; Antoniolli, Ângelo Roberto

doi:10.1016/j.fitote.2005.07.002

Cited by 60 publications

(56 citation statements)

References 15 publications

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“…However, Ev was able to inhibit significantly the dextraninduced paw edema, showing, at both doses, the better results (reduced the paw edema significantly from the 1 st to the 24 th hour). Similar results with the leaves of Ev were also demonstrated by other research (Marchioro et al, 2005). Taken together these results suggest that the mast cells and inflammatory mediators, such as histamine and serotonin, seem to play an important role in the antiinflammatory effects of HAE of Em.…”

Section: Discussionsupporting

confidence: 89%

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Anti-inflammatory activities of the hydroalcoholic extracts from Erythrina velutina and E. mulungu in mice

Vasconcelos¹,

Sales²,

Lima³

et al. 2011

Rev. bras. farmacogn.

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This work studied the anti-inflammatory activities of the hydroalcoholic extracts (HAEs) from Erythrina velutina Willd. (Ev) and E. mulungu Mart. ex Benth. (Em) in the carrageenan-and dextran-induced mice hind paw edema models. These medicinal plants belonging to the Fabaceae family are used in some Brazilian communities to treat pain, inflammation, insomnia and disorders of the central nervous system. In the present work, the extracts were administered orally in male mice at the doses of 200 or 400 mg/kg. In the carrageenan-induced test, only Em showed anti-inflammatory activity, decreasing the paw edema, at the doses of 200 and 400 mg/kg. No effect was observed with Ev in this model. On the other hand, in the dextran model, Ev demonstrated anti-inflammatory effect, showing decrease of the paw edema at the 1, 2, 3, 4 and 24 th h. Em (200 or 400 mg/kg) presented antiinflammatory effect at the 2, 3 and 4 th h after administration of dextran, as compared to control. In conclusion, the work showed that Ev and Em present anti-edematous actions, which possibly occurs by distinct mechanisms. While Ev seems to interfere especially in inflammatory processes in which mast cells have an important role, Em exerts greater activity in the inflammatory process that depends mainly on polymorphonuclear leucocytes. However, further studies are needed to determine the exact mechanism of action of the species investigated.

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Section: Discussionsupporting

confidence: 89%

“…Many species of the genus Erythrina are used in Brazilian folk medicine to treat central nervous system diseases (Marchioro et al, 2005). Among these, there are Erythrina velutina Willd.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory activities of the hydroalcoholic extracts from Erythrina velutina and E. mulungu in mice

Vasconcelos¹,

Sales²,

Lima³

et al. 2011

Rev. bras. farmacogn.

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“…Considering that peripherally acting nonsteroidal drugs, such as dipyrone and indomethacin, inhibit the writhing response in the abdominal constriction model, these compounds were used as standard drugs. Peripheral drugs are cyclooxygenase (COX) inhibitors and show activity in this model (Deraedt et al, 1980;Marchioro et al, 2005). Therefore, it is possible the extract, fraction and 1, in mimicking indomethacin, may have a peripherally mediated activity, which may be associated partly with lipooxygenase and/or cyclooxygenase.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, 1 mimicked the effects of morphine, which indicated supraspinal antinociceptive effect with central activity. In the formalin model, however, there is a distinctive biphasic nociceptive response in which the first (or neurogenic) phase is associated with the irritating effect of formalin on the sensory fibers of type C, while the second phase represents inflammatory pain in response to the release of serotonin, histamine, bradykinin, and prostaglandins and, at least to some degree, central nociceptive neuron sensitization (Marchioro et al, 2005). Drugs that act primarily on the central nervous system inhibit both phases equally, while peripherally acting drugs inhibit the second phase (Chen et al, 1995;Marchioro et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive effects of an extract, fraction and an isolated compound of the stem bark of Maytenus rigida

Martins¹,

Estevam²,

Santos³

et al. 2012

Rev. bras. farmacogn.

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Abstract:The antinociceptive activity of the Maytenus rigida Mart. (Celastraceae) ethanol extract and its ethyl acetate fraction as well as of (-)-4′-methylepigallocatechin (1), a previously isolated compound, was demonstrated in vivo. ED50 for 1 in the writhing test was 14.14 mg/kg. The acetic acid-induced writhing was inhibited by 98.4, 84.4, and 58.3%, respectively, when mice were treated with the ethanol extract, ethyl acetate fraction, and 1. In the hot plate test, mice pretreated with 1 showed signifi cantly increased reaction times (60-89%). Oral administration of 1 signifi cantly inhibited fi rst and second phases of the formalin-induced pain (50 and 26.5%, respectively), whereas indomethacin inhibited only the second phase of the test (41.2%). Ethanol extract and its fraction showed effects on infl ammatory pain, while neurogenic and infl ammatory pain suppression by 1 is a strong indication of the presence of both central and peripheral effects and suggests its analgesic and anti-infl ammatory potential.

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“…The percentage reduction in the number of abdominal contractions (writhing) indicates the level of analgesia in the acetic acid writhing reflex model [19]. i.p injection of acetic acid causes pain by liberating endogenous substances such as prostaglandins (PGs), serotonin, histamine, bradykinins, and substance P, which stimulate nerve endings [20]. Local peritoneal receptors are postulated to be involved in the abdominal constrictions response [21].…”

Section: Salwe Et Almentioning

confidence: 99%

Evaluation of Analgesic Activity of Murraya Koenigii and Coriandrum Sativum Leaves Extract in Animal Model.

Mano

et al. 2018

Asian J Pharm Clin Res

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Objective: The objective of the study was to investigate the analgesic activity of hydroalcoholic extract of Murraya koenigii and Coriandrum sativum leaves and compared it with standard drug in an animal model. Methods:Hydroalcoholic extracts of M. koenigii and C. sativum leaves were obtained using Soxhlet apparatus. The central analgesic property was screened by hot plate method in mice and tail flick method in rats. The pain reaction time (PRT) was measured at 30, 60, and 120 min. The peripheral analgesic activity was evaluated by acetic acid induced writhing in mice. Results:In hot plate method M. koenigii leaves extract at both doses and tramadol showed significant increase in PRT at 30, 60, and 120 min compared with control group. C. sativum leaves extract showed significant increase in PRT only at 60 and 120 min compared to control group. In tail flick method M. koenigii leaves extract at both doses, higher dose of C. sativum leaves extract and tramadol showed significant increase in PRT at 30, 60, and 120 min compared with control group. Higher dose of M. koenigii leaves extract (200 mg/kg) was comparable with standard drug tramadol in both the methods. M. koenigii leaves extract at both dose showed significant reduction in the number of writhing but C. sativum leaves extract failed to show any significant reduction in the number of writhing compared with control. Higher dose of M. koenigii leaves extract was comparable with standard drug tramadol. Conclusion:M. koenigii leaves extract showed both peripheral and central analgesic effect while C. sativum leaves extract showed only peripheral analgesic effect.

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Anti-nociceptive activity of the aqueous extract of Erythrina velutina leaves

Cited by 60 publications

References 15 publications

Anti-inflammatory activities of the hydroalcoholic extracts from Erythrina velutina and E. mulungu in mice

Anti-inflammatory activities of the hydroalcoholic extracts from Erythrina velutina and E. mulungu in mice

Antinociceptive effects of an extract, fraction and an isolated compound of the stem bark of Maytenus rigida

Evaluation of Analgesic Activity of Murraya Koenigii and Coriandrum Sativum Leaves Extract in Animal Model.

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