Antinociceptive effects of an extract, fraction and an isolated compound of the stem bark of Maytenus rigida

Abstract

Abstract:The antinociceptive activity of the Maytenus rigida Mart. (Celastraceae) ethanol extract and its ethyl acetate fraction as well as of (-)-4′-methylepigallocatechin (1), a previously isolated compound, was demonstrated in vivo. ED50 for 1 in the writhing test was 14.14 mg/kg. The acetic acid-induced writhing was inhibited by 98.4, 84.4, and 58.3%, respectively, when mice were treated with the ethanol extract, ethyl acetate fraction, and 1. In the hot plate test, mice pretreated with 1 showed signifi cantly increased reaction times (60-89%). Oral administration of 1 signifi cantly inhibited fi rst and second phases of the formalin-induced pain (50 and 26.5%, respectively), whereas indomethacin inhibited only the second phase of the test (41.2%). Ethanol extract and its fraction showed effects on infl ammatory pain, while neurogenic and infl ammatory pain suppression by 1 is a strong indication of the presence of both central and peripheral effects and suggests its analgesic and anti-infl ammatory potential.

Tingenone, a Pentacyclic Triterpene, Induces Peripheral Antinociception Due to Opioidergic Activation

“…For example, the hexane and ethyl acetate extracts of Maytenus ilicifolia inhibited formaldehyde-induced nociception and paw edema in mice and carrageenan-induced paw edema in rats [10], while the chloroform extract of Maytenus senegalensis reduced edema induced by croton oil in mice [8]. The antinociceptive effect of Maytenus rigida [11] and the anti-inflammatory effect of Maytenus heterophylla [12] were also demonstrated. Our previous phytochemical study of Maytenus imbricata roots resulted in the isolation and characterization of pentacyclic triterpenes, including tingenone [13].…”

In Vivo Antinociceptive, Muscle Relaxant, Sedative, and Molecular Docking Studies of Peshawaraquinone Isolated from Fernandoa adenophylla (Wall. ex G. Don) Steenis

“…Martins et al isolated (−)-4′-methylepigallocattechin from Maytenus rigida Mart. which demonstrated the antinociceptive activity in mice . Rodrigues et al.…”

“…which demonstrated the antinociceptive activity in mice. 29 Rodrigues et al investigated the antinociceptive effect of three alkaloids (dihydro-piplartine, piplartine, and 3,4,5-trimethoxydihydrocinnamic acid) and crude extracts from the fruits of Piper tuberculatum J ACQ (Piperaceae). 30 Similarly, essential oils and their monoterpenes/sesquiterpenes possess analgesic properties.…”

Photoprotective property and cytotoxicity of polar extracts of three species of Maytenus native to the Southwest of Bahia

“…This species is rich in bioactive metabolites, which have properties such as antimicrobial [20], antinoceptive [21], antioxidant [22], antiulcerogenic [23] and other pharmacological effects. From M. rigida were isolated friedelan-3-one, friedelan-3β-ol, lupeol and hydroxyl derivatives, rigidenol, ursolic acid, 4'-O-methyl-(-)-epigallocatechin, wilforine, proanthocyanidins A and B [21,22,[24][25][26][27].…”