Anti-nociceptive mechanisms of flavonoids-rich methanolic extract from Terminalia coriacea (Roxb.) Wight &amp; Arn. leaves

Khan, Mohammed Safwan Ali; Ahmed, Naseer; Misbah,; Arifuddin, Mohammed; Zakaria, Zainul Amiruddin; Al-Sanea, Mohammad M.; Khundmiri, Syeda Umme Kulsoom; Ahmed, Inshah; Ahmed, Saleha; Mok, Pooi Ling

doi:10.1016/j.fct.2018.03.021

Cited by 11 publications

(3 citation statements)

References 51 publications

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“…The first one was the formalin test with neuronal pain (first phase) and inflammatory pain (second phase). Because acetic acid induces pain by indirectly releasing endogenous mediators, such as prostaglandin E2 (PGE2), to stimulate nociceptive neurons, it is often used in the screening of peripheral analgesic drugs [71]. The hot plate method is a physical stimulus reaction involving the advanced central nervous system, which can reflect the central analgesic effect [72].…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Analysis, Antioxidant and Analgesic Activities of Incarvillea compacta Maxim from the Tibetan Plateau

et al. 2019

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Incarvillea compacta Maxim is a traditional Tibetan plant widely used to treat rheumatic pain and bruises. We conducted qualitative analyses by liquid chromatography-mass spectrometry and quantitative analyses of the total phenols, flavonoids, and alkaloids content of different extracts of I. compacta Maxim. Antioxidant and analgesic activity were analyzed. The results showed that the methanol extract had the highest content of the various ingredients. A total of 25 constituents were identified, of which compounds 1–23 were found for the first time in this plant. The water extract had the highest capacity to clear free radicals in the antioxidant test. The water extract had dose-dependent analgesic effects in the first and second phase in a formalin test. The latency of pain from a hot-plate test was augmented by the water extract when the dose was greater than or equal to 30 g/kg. The water extract significantly decreased the amount of writhing in a dose-dependent manner compared with the control group in the acetic acid-induced writhing test. These results showed that I. compacta Maxim is a new antioxidant and analgesic agent, and this study provides information on its ingredients for further study.

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Section: Discussionmentioning

confidence: 99%

Phytochemical Analysis, Antioxidant and Analgesic Activities of Incarvillea compacta Maxim from the Tibetan Plateau

et al. 2019

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“…The solution was injected at a depth of 4.5-5 cm into the NMR tubes. The spectra were taken using the scale, and tetramethylsilane (TMS) was used as the internal standard on a 500 MHz Bruker Advance instrument (Khan et al 2018).…”

Section: Hplc Analysis Of the Emodinmentioning

confidence: 99%

“…The number of carbon atoms in the sample was determined using NMR 13 C. Spectra were produced using DMSO at 500 MHz (on scale) using a sample prepared in DMSO (Khan et al 2018). The studies were carried out using an NMR spectrometer set at 100.52 MHz for 13 C and 400 MHz for 1 H, with DMSO as a solvent.…”

Section: Hplc Analysis Of the Emodinmentioning

confidence: 99%

Bio-efficacy of insecticidal molecule emodin against dengue, filariasis, and malaria vectors

Ragavendran

Balasubramani

Venkatesh

et al. 2023

Environ Sci Pollut Res

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Emodin, a chemical isolated from Aspergillus terreus, was studied using chromatographic and spectroscopic methods and compound purity (96%) was assessed by TLC. Furthermore, high larvicidal activity against Aedes aegypti-AeA (LC 50 5.08 and LC 90 8.23 mg.L − 1 ), Culex quinquefasciatus-CuQ (7.13 and 12.01 mg.L − 1 ), and Anopheles stephensi-AnS larvae (6.40 and 15.24 mg.L − 1 ) was recorded. The rst isolated fraction showed higher pupicidal activity against AeA (0.349 and 0.872 mg.L − 1 ). Most emodintreated larvae (ETL) involutate variations in acetylcholine esterase, α and β-carboxylesterases, and phosphatase activities in the 4th instar, indicating intrinsic differences in their biochemical changes. ETL had numerous altered tissues, including muscle, gastric caeca, hindgut, midgut, nerve ganglia, and midgut epithelium. Acute toxicity of emodin against brine shrimp Artemia nauplii (154.0 and 184.5 mg.L − 1 ) and the zebra sh Danio rerio (less toxicity observed) was evaluated. In docking studies, Emodin interacted well with odorant-binding-proteins of AeA, AnS, and CuQ with docking scores of -8.89, -6.53, and − 8.09 kcal/mole, respectively. Therefore, A. terreus is likely to be effective against mosquito larvicides.

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Protective effects of a polyphenol-enriched fraction of the fruit peel of Annona crassiflora Mart. on acute and persistent inflammatory pain

et al. 2019

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Anti-nociceptive mechanisms of flavonoids-rich methanolic extract from Terminalia coriacea (Roxb.) Wight & Arn. leaves

Cited by 11 publications

References 51 publications

Phytochemical Analysis, Antioxidant and Analgesic Activities of Incarvillea compacta Maxim from the Tibetan Plateau

Phytochemical Analysis, Antioxidant and Analgesic Activities of Incarvillea compacta Maxim from the Tibetan Plateau

Bio-efficacy of insecticidal molecule emodin against dengue, filariasis, and malaria vectors

Protective effects of a polyphenol-enriched fraction of the fruit peel of Annona crassiflora Mart. on acute and persistent inflammatory pain

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