Phytochemical Analysis, Antioxidant and Analgesic Activities of Incarvillea compacta Maxim from the Tibetan Plateau

Guo, Jiajia; Zhang, Dan; Yao, Ling; Chen, Zhuo; Tao, Yanduo; Cao, Wenxi

doi:10.3390/molecules24091692

Cited by 11 publications

(10 citation statements)

References 78 publications

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“…A recent study [27] showed that the FRAP and DPPH radical-scavenging activity of the ethanol extract of Melissa officinalis L. leaves were lower than ascorbic acid (control), which were consistent with our present findings. However, the current study has confirmed that the in vitro antioxidant activities of HFF are stronger than Impatiens balsamina L. [18], Agastache rugosa (Korean mint) [28], and Incarvillea compacta Maxim [29]. It is generally proven that the antioxidant activity of plants depends on the amounts of biologically active compounds (flavonoids, phenolics, phenylpropanoids, etc.).…”

Section: In Vitro Antioxidant Activities Of Hff Extractssupporting

confidence: 67%

Antioxidant, Antifungal Activities of Ethnobotanical Ficus hirta Vahl. and Analysis of Main Constituents by HPLC-MS

et al. 2020

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The medicinal and edible plant, Ficus hirta Vahl. (also called hairy fig), is used for the treatment of constipation, inflammation, postpartum hypogalactia, tumors, and cancer. There is an urgent need for scientific evaluation to verify the pharmacological properties of F. hirta. Therefore, in vitro assays evaluated the antioxidant and antifungal activities of various solvent extracts of hairy fig fruits (HFF). HFF extracts had abundant antioxidant components for a significant amount of total phenolic (TPC) and flavonoid contents (TFC) (TPC from 17.75 ± 0.52 to 85.25 ± 1.72 mg gallic acid/g dw and TFC from 15.80 ± 0.59 to 144.22 ± 8.46 mg rutin/g dw, respectively). The ethyl acetate extract (EAE) and acetone extract (AE) of HFF demonstrated potent antioxidant activities against 1,1-diphenyl-2-picrylhydrazyl (DPPH) (IC50 values of 2.52 and 2.02 mg/mL, respectively) and ABTS radicals (IC50 values of 3.06 and 9.26 mg/mL, respectively). Moreover, the AE with a high TFC showed a prominent in vitro and in vivo antifungal activity against Penicillium italicum, causing citrus blue mold. Eighteen metabolites were identified or putatively identified from six HFF extracts. Current findings indicated that HFF extracts had significant antioxidant and antifungal activities and could potentially be used as an alternative agent for the preservation of agricultural products.

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Section: In Vitro Antioxidant Activities Of Hff Extractssupporting

confidence: 67%

Antioxidant, Antifungal Activities of Ethnobotanical Ficus hirta Vahl. and Analysis of Main Constituents by HPLC-MS

et al. 2020

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“…Past research described the V. amygdalina was one of the potential therapeutic to analyse toxicity test [50]. The Carrageenan provoked rat was a better model to estimate the anti-oedematous effects of herbal yield with biphasic in nature [51]. The primary phase involving in the discharge of serotonin and the expressing of histamine in the second phase (after 1 h) was mediated by prostaglandins, cyclooxygenase harvest and the stability lying between two phases was offered by kinins [52].…”

Section: Discussionmentioning

confidence: 99%

Zinc oxide nanoparticles synthesised from the Vernonia amygdalina shows the anti-inflammatory and antinociceptive activities in the mice model

Liu

Kang

Liu³

et al. 2020

Artificial Cells, Nanomedicine, and Biotechnology

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In this study, we synthesised the zinc oxide nanoparticles from Vernonia amygdalina and evaluated its anti-inflammatory and antinociceptive potentials against the different inflammation and pain induced mice model. The synthesised zinc oxide nanoparticles were characterised by UV, SEM, XRD and FTIR techniques. The anti-nociceptive effects of V. amygdalina were examined by different stimuli e.g. acetic acid, glutamate, capsaicin, and formalin-induced nociception in mice. The anti-inflammatory effects of synthesised zinc oxide nanoparticles were assessed by air sack assessment and the level of inflammatory cytokines were studied. The muscle tension of animals were studied through open field assessment. The present study exhibited proficient antinociceptive and anti-inflammatory actions of the synthesised Zinc oxide nanoparticles from V. amygdalina. The sormulated zinc oxide nanoparticles were appreciably reduced the acetic acid, glutamate, capsaicin, and formalin-induced nociceptive responses in mice. Further the zinc nanoparticles were exhibited the potent anti-inflammatory actions via reducing the inflammatory response and pro-inflammatory cytokines level in the mice. In conclusion, the findings of this study proved the beneficial effects of zinc oxide nanoparticles from V. amygdalina against the different pain and inflammation-induced mice. Hence, it was clear that the zinc nanoparticles from V. amygdalina could be promising antinociceptive and anti-inflammatory agent in the future.

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“…(1) 1,1-Diphenyl-2-picrylhydrazyl (DPPH) Assay . The scavenging ability of the DPPH free radicals of the three extracts was determined using the reported methods [ 11 , 12 ]. DPPH (0.09 mM of methanol) (0.8 mL) was added to the extraction solution of different concentrations (0.2 mL).…”

Section: Methodsmentioning

confidence: 99%

In Vitro and In Vivo Antioxidative Activity against Radiation‐Induced Damage and the Systematic Chemical Components of Different Extracts of Lagotis brevituba Maxim

Zhang

Tan

Yao

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Lagotis brevituba Maxim is a perennial species distributed in the highlands of China, which has been used for more than 2000 years as a traditional Tibetan medicinal plant. However, no attention has been paid to the antioxidant activities of Lagotis brevituba Maxim in vitro or in vivo. Thus, this study aimed to evaluate the in vitro and in vivo antioxidant activity of Lagotis brevituba Maxim against radiation-induced damage as well as the systematic chemical components. To explore the relationship between the antioxidant activity and extraction solvent, Lagotis brevituba Maxim was extracted with three different solvents: methanol, water, and acetone. In antioxidant assays in vitro, the water extract had the strongest reducing power, 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) radical, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity compared with the methanol and acetone extracts. However, the methanol extract was more potent in the β-carotene/linoleic acid cooxidation assay. In antioxidant assays in vivo, mice that were exposed to 6.0 Gy60Co γ-ray whole-body radiation on day 15 after administration of Lagotis brevituba Maxim decreased their level of malondialdehyde (MDA) in a dose-dependent manner compared with the control group, indicating that Lagotis brevituba Maxim had favorable antioxidant activities in vivo. In addition, a total of 44 compounds were tentatively identified by liquid chromatography electrospray ionization quadrupole time-of-flight mass spectrometry (LC-ESI-QTOF-MS/MS), including 19 flavonoids, 14 phenols, 8 phenylethanoid glycosides, 2 iridoid glycosides, and 1 carbohydrate. We obtained 25 compounds from plants in the genus Lagotis for the first time. These results suggested that Lagotis brevituba Maxim had potent antioxidant activity and could be explored as a novel natural antioxidant.

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Phytochemical Analysis, Antioxidant and Analgesic Activities of Incarvillea compacta Maxim from the Tibetan Plateau

Cited by 11 publications

References 78 publications

Antioxidant, Antifungal Activities of Ethnobotanical Ficus hirta Vahl. and Analysis of Main Constituents by HPLC-MS

Antioxidant, Antifungal Activities of Ethnobotanical Ficus hirta Vahl. and Analysis of Main Constituents by HPLC-MS

Zinc oxide nanoparticles synthesised from the Vernonia amygdalina shows the anti-inflammatory and antinociceptive activities in the mice model

In Vitro and In Vivo Antioxidative Activity against Radiation‐Induced Damage and the Systematic Chemical Components of Different Extracts of Lagotis brevituba Maxim

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