Anti-obesity and anti-diabetic effects of Yerba Mate (Ilex paraguariensis) in C57BL/6J mice fed a high-fat diet

Abstract

Yerba Mate, derived from the leaves of the tree, Ilex paraguariensis, is widely-used as a tea or as an ingredient in formulated foods. The aim of the present study was to evaluate the effects of Yerba Mate extract on weight loss, obesity-related biochemical parameters, and diabetes in high-fat diet-fed mice.To this end, by using in vivo animal models of dietary-induced obesity, we have made the interesting observations that Yerba Mate has the ability to decrease the differentiation of pre-adipocytes and to reduce the accumulation of lipids in adipocytes, both of which contribute to a lower growth rate of adipose tissue, lower body weight gain, and obesity. Our data from in vivo studies revealed that Yerba Mate treatment affects food intake, resulting in higher energy expenditure, likely as a result of higher basal metabolism in Yerba Mate-treated mice. Furthermore, in vivo effects of Yerba Mate on lipid metabolism included reductions in serum cholesterol, serum triglycerides, and glucose concentrations in mice that were fed a high fat diet. In conclusion, Yerba Mate can potentially be used to treat obesity and diabetes.

Analgesic Effect of <i>Ilex paraguariensis</i> Extract on Postoperative and Neuropathic Pain in Rats

“…8) Recently published evidence has shown some beneficial effects of Mate, including antioxidant, 9) antiinflammatory, 10) antiobesity, 11) antihyperlipidemic, 12) and antidiabetic properties. 13) To our knowledge, based on pain-related experimental evidence, little is known about the potential analgesic effects of Mate.…”

A Review of Combination Effects and Adverse Effects of Yerba Mate (Ilex paraguariensis) on the Treatment of Obesity

“…비 만에 대한 효과는 열발생효과(thermogenesis) 6) , 지방대 사증진 효과 7) , 지방세포 크기를 줄이는 효과 8) , GLP-1(glucagon-like peptide-1)과 렙틴 분비의 증가를 통한 식욕억제 효과 9) , 그리고 지질생성(adipogenesis)과 관련 된 유전자의 발현을 조절하는 효과 에 발표되었다. 반면에 마테가 topoisomerase Ⅱ 활동의 억제를 통해 구강암 13) 과 사람의 간암세포 (HepG2) 14) 의 증식을 막는다는 in vitro 연구들도 있어 발 암 가능성에 대해 논쟁이 많다.…”

Phytochemistry and biology of Ilex pharmaceutical resources

“…Additionally, mate extract had a modulatory effect on the expression of several genes related to obesity (Arçari et al, 2009). Mate extract has the ability to decrease the differentiation of preadipocytes and to reduce the accumulation of lipids in adipocytes, both of which contribute to a lower growth rate of adipose tissue, lower body weight gain, and obesity (Kang et al, 2012). Mate extract has the ability to decrease the differentiation of preadipocytes and to reduce the accumulation of lipids in adipocytes, both of which contribute to a lower growth rate of adipose tissue, lower body weight gain, and obesity (Kang et al, 2012).…”