Anti-obesity and Hypolipidemic Activity of Methanol Extract of Tecoma stans Flowers on Atherogenic Diet Induced Obesity in Rats

Kameshwara, S.; Jothimaniv, R.; Senthilkum, R.; Kothai, A.R.

doi:10.5567/pharmacologia.2013.77.81

Cited by 8 publications

(4 citation statements)

References 6 publications

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“…Treatment with 200 mg/kg and 400 mg/kg significantly attenuated the atherogenic index and In order to supplement the results, the histopathological studies were also performed. The literature review revealed that high fat diet-induced obesity and abnormal lipid metabolism all collectively are associated with inflammation, congestion, and nonalcoholic fatty liver disease (NAFLD) leading to hepatic failure causing a boost in SGOT, SGPT, and total bilirubin level in the serum [52][53][54]. Our results showed that consumption of high-fat diet may play a crucial role in the pathogenesis of fatty liver or hepatic steatosis associated with obesity depicted via ballooning degeneration.…”

Section: Discussionmentioning

confidence: 67%

Antiobesity and Hypolipidemic Activity ofMoringa oleiferaLeaves against High Fat Diet-Induced Obesity in Rats

Bais

Singh

Sharma

2014

Advances in Biology

104

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In the present study, the methanolic extract ofMoringa oleiferaleaves (MEMOL) was evaluated for antiobesity activity in rats. The antiobesity potential of MEMOL was studied against high fat diet-induced obesity (HFD) in rats. In this study, chronic administration of HFD in rats produced hypercholesterolemia (116.2 ± 0.27 mg/dL), which led to an increase in the body weight (225 gr), total cholesterol, triglycerides (263.0 ± 4.69 mg/dL), and attenuation in the levels of HDL (34.51 ± 2.20 mg/dL) as well as changes in body temperature of animals. Treatment of obese rats with MEMOL for 49 days resulted in a significant (P<0.001) change in body weight, total cholesterol, triglycerides, and LDL level along with a significant (P<0.001) increase in body temperature as compared to the HFD-induced obesity. MEMOL treated rats also showed a significant decrease in the level of liver biomarkers, organ weight, and blood glucose level. Further, rats treated with MEMOL (200 mg and 400 mg/kg) show reduced atherogenic index (1.7 ± 0.6 and 0.87 ± 0.76). The results indicate that the rats treated withMoringa oleifera(MO) have significantly attenuated the body weight without any change in the feed intake and also elicited significant thermogenic effect and to act as hypolipidemic and thermogenic property in obesity related disorders.

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Section: Discussionmentioning

confidence: 67%

Antiobesity and Hypolipidemic Activity ofMoringa oleiferaLeaves against High Fat Diet-Induced Obesity in Rats

Bais

Singh

Sharma

2014

Advances in Biology

104

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“…Obesity has been associated with numerous disturbances such as cardiovascular disease (CVD), atherosclerosis ( Azimi et al, 2013 , Ouimet, 2013 ), osteoarthritis ( Collins et al, 2018 ), type 2 diabetes ( Nath et al, 2006 ) and hypertension ( Dorresteijn et al, 2012 ), respiratory disorders ( Zammit et al, 2010 ), chronic musculoskeletal problems ( Onyemaechi et al, 2016 ), lumbago ( Shiri et al, 2009 ), skin problems ( Yosipovitch et al, 2007 ), infertility ( Bazzano et al, 2015 ) and certain cancers ( Vucenik and Stains, 2012 ). Also, HFD induces obesity and abnormal lipid metabolism that is subsequently associated with accumulation of fat in the liver ( Altunkaynak, 2005 , Kameshwaran et al, 2013 ). Moreover, it is accompanied with low-grade inflammation ( Monteiro and Azevedo, 2010 ) and increased adipose tissue that releases several adipokines and pro-inflammatory factors, such as, interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α) and interleukin 1 β (IL-1 β) ( Henry et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Anti-obesity potential of Moringa olifera seed extract and lycopene on high fat diet induced obesity in male Sprauge Dawely rats

Kilany

Abdelrazek

Aldayel

et al. 2020

Saudi Journal of Biological Sciences

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Present research explored the anti-obesity effect of Moringa olifera seed oil extract and lycopene (LYC). Forty eight male Sprauge Dawely rats were divided equally into 6 groups. Group Ι (C) served as control, group ΙΙ (MC) was given Moringa olifera seed oil extract (800 mg/kg b.wt) for 8 weeks, group ΙΙΙ (LC) was given (20 mg/kg b.wt) LYC for 8 weeks, group ΙV (O) received high fat diet (HFD) for 20 weeks, group Ѵ (MO), was given HFD for 20 weeks and received (800 mg/kg b.wt) Moringa olifera seed oil extract for last 8 weeks and group ѴΙ (LO), received HFD for 20 weeks and was given (20 mg/kg b.wt) LYC for last 8 weeks. Hematology, lipid peroxidation and antioxidants, non-esterified fatty acids (NEFA), glucose, lipid profile, serum liver and kidney biomarkers, inflammatory markers, leptin, resistin and heart fatty acid binding protein (HFABP) were determined. Also histopathology for liver, kidney and aorta were performed besides immunohistochemistry (IHC) for aortic inducible nitric oxide synthase (iNOS). Administration of Moringa olifera seed oil extract and LYC significantly ameliorated the HFD induced hematological and metabolic perturbations as well as reduced leptin and resistin. Both treatments exerted these effects through promotion of antioxidant enzymes and reducing lipid peroxidation as well as inflammatory cytokines along with reduced iNOS protein expression. Administration of Moringa olifera seed oil extract and LYC have anti-obesity potential in HFD induced obesity in male Sprauge Dawely rats.

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“…Because of the entry of high glucose levels into the mitochondria in hyperglycemia, the beta cells are damaged. With apparent hyperglycemia and a higher HOMA‐IR, the obese group acquired insulin resistance (Kameshwaran et al., 2013 ). In the present study, our results emphasized that using the Zingiber extract in combination with simvastatin enhanced glucose level, insulin level, HOMA IR, and leptin by 3.2%, 6.25%, 5.26%, and 3.9%, respectively, compared to HFD‐fed rats receiving SIM alone.…”

Section: Discussionmentioning

confidence: 99%

Zingiber officinale extract maximizes the efficacy of simvastatin as a hypolipidemic drug in obese male rats

Abdelhamid,

Sherif,

Abaza

et al. 2023

Food Science & Nutrition

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Obesity became a serious public health problem with enormous socioeconomic implications among the Egyptian population. The present investigation aimed to explore the efficacy of Zingiber officinale extract as a hypolipidemic agent combined with the commercially well‐known anti‐obesity drug simvastatin in obese rats. Thirty‐five male Wister rats were randomly divided into five groups as follows: group I received a standard balanced diet for ten weeks; high‐fat diet was orally administered to rats in groups II–V for ten weeks. From the fifth week to the tenth week, group III orally received simvastatin (40 mg/kg B.W.), group IV orally received Z. officinale root extract (400 mg/kg B.W.), and group V orally received simvastatin (20 mg/kg B.W.) plus Z. officinale extract (200 mg/kg B.W.) separately. Liver and kidney function tests, lipid profiles, serum glucose, insulin, and leptin were determined. Quantitative RT‐PCR analysis of PPAR‐γ, iNOS, HMG‐CoA reductase, and GLUT‐4 genes was carried out. Caspase 3 was estimated in liver and kidney tissues immunohistochemically. Liver and kidney tissues were examined histologically. The administration of Z. officinale extract plus simvastatin to high‐fat diet‐fed rats caused a significant reduction in the expression of HMG‐coA reductase and iNOS by 41.81% and 88.05%, respectively, compared to highfat diet (HFD)‐fed rats that received simvastatin only. Otherwise, a significant increase was noticed in the expression of PPAR‐γ and GLUT‐4 by 33.3% and 138.81%, respectively, compared to those that received simvastatin only. Immunohistochemistry emphasized that a combination of Z. officinale extract plus simvastatin significantly suppressed caspase 3 in the hepatic tissue of high‐fat diet‐fed rats. Moreover, the best results of lipid profile indices and hormonal indicators were obtained when rats received Z. officinale extract plus simvastatin. Z. officinale extract enhanced the efficiency of simvastatin as a hypolipidemic drug in obese rats due to the high contents of flavonoid and phenolic ingredients.

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Anti-obesity and Hypolipidemic Activity of Methanol Extract of Tecoma stans Flowers on Atherogenic Diet Induced Obesity in Rats

Cited by 8 publications

References 6 publications

Antiobesity and Hypolipidemic Activity ofMoringa oleiferaLeaves against High Fat Diet-Induced Obesity in Rats

Antiobesity and Hypolipidemic Activity ofMoringa oleiferaLeaves against High Fat Diet-Induced Obesity in Rats

Anti-obesity potential of Moringa olifera seed extract and lycopene on high fat diet induced obesity in male Sprauge Dawely rats

Zingiber officinale extract maximizes the efficacy of simvastatin as a hypolipidemic drug in obese male rats

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