Anti-obesity potential of Moringa olifera seed extract and lycopene on high fat diet induced obesity in male Sprauge Dawely rats

Abstract

Present research explored the anti-obesity effect of Moringa olifera seed oil extract and lycopene (LYC). Forty eight male Sprauge Dawely rats were divided equally into 6 groups. Group Ι (C) served as control, group ΙΙ (MC) was given Moringa olifera seed oil extract (800 mg/kg b.wt) for 8 weeks, group ΙΙΙ (LC) was given (20 mg/kg b.wt) LYC for 8 weeks, group ΙV (O) received high fat diet (HFD) for 20 weeks, group Ѵ (MO), was given HFD for 20 weeks and received (800 mg/kg b.wt) Moringa olifera seed oil extract for last 8 weeks and group ѴΙ (LO), received HFD for 20 weeks and was given (20 mg/kg b.wt) LYC for last 8 weeks. Hematology, lipid peroxidation and antioxidants, non-esterified fatty acids (NEFA), glucose, lipid profile, serum liver and kidney biomarkers, inflammatory markers, leptin, resistin and heart fatty acid binding protein (HFABP) were determined. Also histopathology for liver, kidney and aorta were performed besides immunohistochemistry (IHC) for aortic inducible nitric oxide synthase (iNOS). Administration of Moringa olifera seed oil extract and LYC significantly ameliorated the HFD induced hematological and metabolic perturbations as well as reduced leptin and resistin. Both treatments exerted these effects through promotion of antioxidant enzymes and reducing lipid peroxidation as well as inflammatory cytokines along with reduced iNOS protein expression. Administration of Moringa olifera seed oil extract and LYC have anti-obesity potential in HFD induced obesity in male Sprauge Dawely rats.

Moringa oleifera Supplementation Improves Antioxidant Status and Biochemical Indices by Attenuating Early Pregnancy Stress in Beetal Goats

“…Our findings were in line with the results of a previous study on Jersey cows (63). In addition, MOLP supplementation also improved the bioavailability of carotenoids and lycopene to ameliorate metabolic and hematological perturbations by reducing LPO and inflammatory cytokines (64).…”

Lycopene is superior to moringa in improving fertility markers in diet-induced obesity male rats

“…This system is based on small scavenging molecules like GSH, and enzymes, which catalytically modify ROS into less harmful forms ( Bais and Sharma, 2014 ). In the current work, HFD decreased SOD, catalase activity, and GSH and increased MDA concentrations compared to RC, indicating a disruption of the antioxidant system with increased lipid peroxidation, as previously reported ( Kilany el al., 2020 ). This is conceivable as elevated oxidative stress has been implicated in obesity, a state of chronic inflammation ( Fernandez-Sanchez et al, 2011 ).…”

“…Medicinal plants have been used for treating obesity for millennia. Moringa or lycopene reduced the weight of HFD-fed animals significantly, suggesting an anti-obesity potential of either ( Bais et al, 2014 ; Pierine et al, 2014 , Xie et al, 2018 ; ( Kilany et al, 2020 ). Either treatment exerted anti-lipidemic effects on HFD-fed animals, consistent with other reports ( Fenni et al, 2017 , Pierine et al, 2014 , Jiang et al, 2015 ; (Kilany et al, 2020) with lycopene being more effective.…”

“…In a recent study, Moringa or lycopene was found to have comparable anti-obesity potential ( Kilany et al, 2020 ). Moringa or lycopene was also reported to improve male fertility parameters in normal or cadmium-induced toxicity rodent model ( Agrawal, 2018 , Gupta and Kumar, 2002 , Khalifa et al, 2016 , Obembe and Raji, 2018 ).…”

A Review on Obesity Management through Natural Compounds and a Green Nanomedicine-Based Approach

“…Different plant extracts with different anti-obesity effects are described in Table 1 . The plant extracts of Curcuma longa [ 76 ], Camellia sinensis [ 77 ], Cosmos cadatus [ 78 ], Morniga olifera [ 79 ] and Elateriospermum tapos [ 80 ] are reported to have anti-obesity efficacy and among these plants Curcuma longa is reported to have the highest anti-obesity potential. It decreased body weight and adipose tissue weight, and more importantly, regulated the expression of transcription factors like PPAR-γ (71 %) and C/EBP-α (38.83%).…”