Anti-obesity, antiatherogenic, anti-diabetic and antioxidant activities of J. montana ethanolic formulation in obese diabetic rats fed high-fat diet

Hussein, Mohammed A.

doi:10.5530/ax.2011.1.9

Cited by 22 publications

(10 citation statements)

References 63 publications

(72 reference statements)

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“…[50] Recent investigations have shown that the antioxidant properties of plants could be correlated with oxidative stress defense and different human diseases. [5][6][7][8] Human organism possesses systems controlling oxidation processes posing a threat to structures and functions of cells. Three defense mechanisms has been developed, [51] including: prevention of reactions of reactive oxygen species with biologically-significant compounds, breaking free-radical chain reactions and undesirable non-radical oxidation reactions, scavenging the products of free radicals reactions with biological substances and repair of damages.…”

Section: Determination Of Reducing Powermentioning

confidence: 99%

Anti-inflammatory and antioxidant activities of Moringa peregrina Seeds

Koheil

Hussein

Othman

et al. 2011

Free Radicals and Antioxidants

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Access Free Rad. Antiox. www.antiox.org of deteriorative changes in the biological systems leading to cell inactivation. [1] Many antioxidant enzymes and compounds present in the cell, mitigate the oxidative stress due to free radicals, by dismutating these free radicals species or by converting these radicals into a less effective forms. [2] Antioxidant supplements or antioxidant-rich food are used to help the human body reduce oxidative damage from free radicals and active oxygen species. [3] Other synthetic antioxidants such as butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA) and trolox are widely used as antioxidants in the pharmaceutical and food industry. However, they have been shown to have toxic and/or mutagenic effects. [2] Because of their toxicity, the development and isolation of natural antioxidants IntroductIon The exogenous chemicals and endogenous metabolites in the body produce reactive oxygen species (ROS), which are capable of oxidizing various biomolecules resulting in tissue damage and cell death. Free radicals have been implicated in the cause of several diseases such as liver cirrhosis, atherosclerosis, cancer and diabetes and play an important role in ageing. Oxidative stress can also contribute to the development of neuro-degenerative disorders, such as Alzheimer's and Parkinson's as well as other diseases. These free radicals attack unsaturated fatty acids of biomembranes, resulting in lipid peroxidation and desaturation of proteins and DNA, causing a series

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Section: Determination Of Reducing Powermentioning

confidence: 99%

Anti-inflammatory and antioxidant activities of Moringa peregrina Seeds

Koheil

Hussein

Othman

et al. 2011

Free Radicals and Antioxidants

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“…The chemical composition of its essential oils showed high scavenging activity against peroxyl radicals [ 14 ]. Furthermore, the plant was found to exhibit anticancer [ 15 , 16 ], antioxidant [ 17 ], anticholestatic [ 18 ], and antimicrobial activities [ 19 ] as well as antiatherogenic [ 20 ] and anti-diabetic efficiency [ 21 , 22 ]. Therefore, C. montanus is considered one of the most valuable medicinal plants in the region and it has great potential as a therapeutic agent against multiple diseases [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Cultures and Volatile Organic Compound Production in Chiliadenus montanus (Vhal.) Brullo

Abu-Darwish

Shibli

Al‐Abdallat

2022

Plants

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Callus and microshoot cultures were established for Chiliadenus montanus (Vhal.) Brullo. (Asteraceae), a medicinal plant known for producing volatile organic compounds (VOCs). Callus induction was achieved successfully by culturing leaf explants on full-strength Murashige and Skoog medium (MS) supplemented with 2.2 µM 2, 4-dichlorophenoxy acetic acid (2,4-D) and 6.9 µM kinetin (Kin). Successful direct shoot regeneration was achieved using nodal explants cultured onto half-strength MS media supplemented with 1.4 μM Gibberellic Acid (GA3) and 4.4 μM 6-Benzylaminopurine (BAP). Indirect microshoots were successfully regenerated using callus cultured on MS media supplemented with 8.8 μM BAP, 2.2 μM Zeatin, and 1.4 μM GA3 followed by culturing on MS media supplemented with 8.8 μM BAP and 0.5 μM naphthalene acetic acid (NAA). Using wild plant aerial parts, callus and microshoots samples, VOCs were extracted successfully using Headspace Solid-Phase Micro-Extraction (HS-SPME) and analyzed by gas chromatography–mass spectrometry (GC-MS). In wild plant extracts, sesquiterpene hydrocarbons were found to be predominant with the following principal components: Alloaromadendrene (11.92%), trans-Cadina-1(6),4-diene (7.54%), and α-caryophyllene (6.77%). The analysis of in vitro microshoots revealed high levels of oxygenated monoterpenes with cis-Myrtanol (16.62%), and β-Cyclocitral (14.3%) as the main components. Callus extract was dominated by monoterpene hydrocarbons and the main compounds identified were (Z)-β-Ocimene (22.27%), p-Cymene (15.13%), and α-pinene (13.78%). In conclusion, an efficient in vitro production system of VOCs in C. montanus was established that can be used in the future for boosting their production without endangering wild plants.

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“…It has a good reputation among the traditional healers and Bedouins as a remedy for various ailments such as chest and kidney problems, diarrhea and stomachache [ 10 , 11 , 12 ]. Several biological studies have proved the hepatoprotective effect [ 13 ], the antidiabetic, antioxidant, anticholestatic and anti-obesity activities of the plant [ 14 , 15 , 16 , 17 ] and its ability to ameliorate the inflammation and neurodegeneration processes characterizing Alzheimer’s disease [ 18 ]. C. montanus owes its unique pharmacological activities to an array of secondary metabolites.…”

Section: Introductionmentioning

confidence: 99%

Jaceidin Flavonoid Isolated from Chiliadenus montanus Attenuates Tumor Progression in Mice via VEGF Inhibition: In Vivo and In Silico Studies

Elhady

Eltamany

Shaaban

et al. 2020

Plants

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Phytochemical study of Chiliadenus montanus aerial parts afforded six compounds; Intermedeol (1), 5α-hydroperoxy-β-eudesmol (2), 5,7-dihydroxy-3,3’,4’-trimethoxyflavone (3), 5,7,4’-trihydroxy-3,6,3’-trimethoxyflavone (jaceidin) (4), eudesm-11,13-ene-1β,4β,7α-triol (5) and 1β,4β,7β,11-tetrahydroxyeudesmane (6). These compounds were identified based on their NMR spectral data. The isolated compounds were tested for their cytotoxicity against liver cancer cell line (HepG2) and breast cancer cell line (MCF-7). Jaceidin flavonoid (4) exhibited the highest cytotoxic effect in vitro. Therefore, both of jaceidin and C. montanus extract were evaluated for their in vivo anti-tumor activity against Ehrlich’s ascites carcinoma (EAC). Compared to control group, jaceidin and C. montanus extract decreased the tumor weight, improved the histological picture of tumor cells, lowered the levels of VEGF and ameliorate the oxidative stress. Molecular docking and in silico studies suggested that jaceidin was a selective inhibitor of VEGF-mediated angiogenesis with excellent membrane permeability and oral bioavailability.

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Anti-obesity, antiatherogenic, anti-diabetic and antioxidant activities of J. montana ethanolic formulation in obese diabetic rats fed high-fat diet

Cited by 22 publications

References 63 publications

Anti-inflammatory and antioxidant activities of Moringa peregrina Seeds

Anti-inflammatory and antioxidant activities of Moringa peregrina Seeds

In Vitro Cultures and Volatile Organic Compound Production in Chiliadenus montanus (Vhal.) Brullo

Jaceidin Flavonoid Isolated from Chiliadenus montanus Attenuates Tumor Progression in Mice via VEGF Inhibition: In Vivo and In Silico Studies

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