2019
DOI: 10.3892/etm.2019.7191
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Anti‑obesity effect in high‑fat‑diet‑induced obese C57BL/6 mice: Study of a novel extract from mulberry (Morus alba) leaves fermented with Cordyceps militaris

Abstract: The therapeutic effects of mulberry ( Morus alba ) leaves on lipid metabolism, including lipogenesis, lipolysis and hyperlipidemia are widely known, although their fermented products are yet to be applied. To investigate the therapeutic effects of a novel extract of mulberry leaves fermented with Cordyceps militaris (EMfC) on lipid metabolism, the lipid profile of serum, lipid accumulation, lipolytic activity and lipogenesis regulation were measured in high fat die… Show more

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Cited by 28 publications
(27 citation statements)
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“…In the liver tissue of above mice, adipocyte size, percentage of crown-like structures, severity of hepatic steatosis, and number of inflammatory foci were remarkably increased compared with normal diet (ND)-fed mice. A similar enhancement was detected on the levels of serum biochemical markers including TC, glucose, and aminotransferases (AST and ALT) in HFD treated mice for 12 weeks [32,[86][87][88]. Also, the increase of insulin and leptin concentration were detected in the same mice [89].…”
Section: Discussionsupporting
confidence: 71%
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“…In the liver tissue of above mice, adipocyte size, percentage of crown-like structures, severity of hepatic steatosis, and number of inflammatory foci were remarkably increased compared with normal diet (ND)-fed mice. A similar enhancement was detected on the levels of serum biochemical markers including TC, glucose, and aminotransferases (AST and ALT) in HFD treated mice for 12 weeks [32,[86][87][88]. Also, the increase of insulin and leptin concentration were detected in the same mice [89].…”
Section: Discussionsupporting
confidence: 71%
“…Extraction mixture containing the fermented mixture and the solvent (fixed ratio 1:10) was sonicated for 1 h using a JAC ultrasonic device (KODO, Hwangseong, Korea) and collected the supernatant after centrifugation at 13,000 xg for 20 min. This resultant supernatant was filtered, evaporated and lyophilized under previously reported conditions to prepare EMfCs [ 32 ]. Finally, EMfC were completely dissolved in dimethyl sulfoxide (DMSO)(#D2660, Sigma-Aldrich Co., St Louis, MO, USA) at a concentration of 50 mg/mL in 1% diluted DMSO solution based on previous studies showing non-toxic concentrations of DMSO to prevent animal toxicity [ 35 ].…”
Section: Methodsmentioning
confidence: 99%
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