Anti‐obesity effect of feeding probiotic dahi containing <i>Lactobacillus casei </i><scp>NCDC</scp> 19 in high fat diet‐induced obese mice

Rather, Sarver A.; Pothuraju, Ramesh; Sharma, Raj Kumar; De, Sachinandan; Mir, Nazir Ahmad; Jangra, Surender

doi:10.1111/1471-0307.12154

Cited by 31 publications

(17 citation statements)

References 30 publications

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“…The administration of T17, however, significantly alleviated insulin resistance and decreased the serum levels of TG, T-CHO and LDL-C in HFD-fed mice, which may be partly explained by the significant increase in adiponectin, assumedly due to the reduction in adipocyte size in accordance with previous studies [31]. Adiponectin is known to play an important role in regulating energy homeostasis, and the improvement in adiponectin as a result of T17 feeding may be linked to the regulation of lipid metabolism, leading to a balanced serum lipid profile [32]. Another hormone synthesized and secreted by adipose tissue, leptin, is produced in proportion to fat stores and exerts negative feedback effects on energy intake to permit energy expenditure.…”

Section: Discussionsupporting

confidence: 86%

Weight-Reducing Effect of Lactobacillus Plantarum ZJUFT17 Isolated from Sourdough Ecosystem

Liu

Zhao

et al. 2020

Nutrients

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Lactobacillus plantarum ZJUFT17 (T17) is a potential probiotic bacterium isolated from Chinese traditional sourdough. The purpose of this study was to investigate its weight-reducing effects in mice fed a high-fat diet (HFD) and further to elucidate possible mechanisms. Male C57BL/6J mice fed HFD were given T17 (2–4 × 108 cfu) intragastrically for 10 weeks. The results showed that the administration of T17 significantly suppressed HFD-induced body weight gain, alleviated HFD-induced increase in serum lipids and decreased energy intake. The serum levels of obesity-related metabolic signaling molecules, including insulin, adiponectin, lipopolysaccharide (LPS) and the cytokines interleukin (IL)-1β and tumor necrosis factor (TNF)-α, were markedly improved. The 16S rRNA gene sequencing revealed that T17 administration dramatically modulated the gut microbiota, suppressing pathogenic and pro-inflammatory microbes and stimulating the microbes favoring anti-obesity. The weight-reducing efficacy of T17 may be explained by its ability to ameliorate systemic inflammation and insulin resistance mediated by gut microbiota. This study revealed that T17 could ameliorate obesity and the concomitant metabolic syndrome in mice and that the lactic acid bacteria in the sourdough ecosystem may also possess anti-obesity/weight-reducing properties.

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Section: Discussionsupporting

confidence: 86%

Weight-Reducing Effect of Lactobacillus Plantarum ZJUFT17 Isolated from Sourdough Ecosystem

Liu

Zhao

et al. 2020

Nutrients

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“…Similarly, a recent study revealed that the abundance of A. muciniphila decreased in HFD-fed mice, which is strongly correlated with weight gain, increased inflammation, increased expression of lipid-metabolism genes in adipose tissues, and increased level of blood markers (e.g., lipid and glucose) in obese mice (Schneeberger et al, 2015). Accumulating evidence shows that probiotic administration leads to a reduction in body weight gain, adipose weight, and obesity biomarkers (e.g., glucose and plasma lipid) in HFD-fed mice (Rather et al, 2014; Parker et al, 2017). In addition, the effect of probiotics on the improvement of metabolism was confirmed in normal mice (Zhao et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Akkermansia muciniphila-Derived Extracellular Vesicles as a Mucosal Delivery Vector for Amelioration of Obesity in Mice

et al. 2019

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Recent evidence suggests that probiotics can restore the mucosal barrier integrity, ameliorate inflammation, and promote homeostasis required for metabolism in obesity by affecting the gut microbiota composition. In this study, we investigated the effect of Akkermansia muciniphila and its extracellular vesicles (EVs) on obesity-related genes in microarray datasets and evaluated the cell line and C57BL/6 mice by conducting RT-PCR and ELISA assays. A. muciniphila-derived EVs caused a more significant loss in body and fat weight of high-fat diet (HFD)-fed mice, compared with the bacterium itself. Moreover, treatment with A. muciniphila and EVs had significant effects on lipid metabolism and expression of inflammatory markers in adipose tissues. Both treatments improved the intestinal barrier integrity, inflammation, energy balance, and blood parameters (i.e., lipid profile and glucose level). Our findings showed that A. muciniphila-derived EVs contain various biomolecules, which can have a positive impact on obesity by affecting the involved genes. Also, our results showed that A. muciniphila and its EVs had a significant relationship with intestinal homeostasis, which highlights their positive role in obesity treatment. In conclusion, A. muciniphila-derived EVs can be used as new therapeutic strategies to ameliorate HFD-induced obesity by affecting various mechanisms.

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“…Another study found that feeding of probiotic dahi, which contains L. casei NCDC 19, led to a reduction in epididymal fat weights, blood glucose, plasma lipids, leptin levels, and body weight among HFD mice (Rather et al, 2014). These observed effects were correlated with an increase in the population of bifidobacteria .…”

Section: Modulation Of Gut Microbiota By Dietary Approaches For Theramentioning

confidence: 99%

Gut Microbiota Modulation and Its Relationship with Obesity Using Prebiotic Fibers and Probiotics: A Review

Dahiya

Renuka

Puniya³

et al. 2017

Front. Microbiol.

283

166

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In the present world scenario, obesity has almost attained the level of a pandemic and is progressing at a rapid rate. This disease is the mother of all other metabolic disorders, which apart from placing an added financial burden on the concerned patient also has a negative impact on his/her well-being and health in the society. Among the various plausible factors for the development of obesity, the role of gut microbiota is very crucial. In general, the gut of an individual is inhabited by trillions of microbes that play a significant role in host energy homeostasis by their symbiotic interactions. Dysbiosis in gut microbiota causes disequilibrium in energy homeostasis that ultimately leads to obesity. Numerous mechanisms have been reported by which gut microbiota induces obesity in experimental models. However, which microbial community is directly linked to obesity is still unknown due to the complex nature of gut microbiota. Prebiotics and probiotics are the safer and effective dietary substances available, which can therapeutically alter the gut microbiota of the host. In this review, an effort was made to discuss the current mechanisms through which gut microbiota interacts with host energy metabolism in the context of obesity. Further, the therapeutic approaches (prebiotics/probiotics) that helped in positively altering the gut microbiota were discussed by taking experimental evidence from animal and human studies. In the closing statement, the challenges and future tasks within the field were discussed.

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Anti‐obesity effect of feeding probiotic dahi containing Lactobacillus casei NCDC 19 in high fat diet‐induced obese mice

Cited by 31 publications

References 30 publications

Weight-Reducing Effect of Lactobacillus Plantarum ZJUFT17 Isolated from Sourdough Ecosystem

Weight-Reducing Effect of Lactobacillus Plantarum ZJUFT17 Isolated from Sourdough Ecosystem

Akkermansia muciniphila-Derived Extracellular Vesicles as a Mucosal Delivery Vector for Amelioration of Obesity in Mice

Gut Microbiota Modulation and Its Relationship with Obesity Using Prebiotic Fibers and Probiotics: A Review

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