Anti-obesity effect of Schisandra chinensis in 3T3-L1 cells and high fat diet-induced obese rats

Schisandra chinensis fruit modulates the gut microbiota composition in association with metabolic markers in obese women: a randomized, double-blind placebo-controlled study

“…This result was not consistent with those of the previous in vivo [33] and in vitro [13] studies, which reported significant beneficial effects on obesity. Nevertheless, the obesity-related parameters such as fat mass and blood biomarkers showed interesting correlation with some gut microbiota.…”

“…Recent studies have shown the anti-obesity effect of SCF and its main components. Schisandra chinensis fruit inhibited preadipocyte differentiation and adipogenesis in 3T3-L1 cells, leading to decreased body weight and fat mass in high-fat dietinduced obese rats [13]. In addition, dibenzocylooctadiene lignans from SCF have fatty acid synthase inhibitory activity, [14] and schisandrin B isolated from SCF reduces hepatic lipid contents in hypercholesterolemic mice [15].…”

Hypolipidemic effect of dihydroisoquinoline oxaziridine in high-fat diet-fed rats

“…The adverse effects of HFD on metabolic homeostasis such as dyslipidemia, diabetes mellitus, and cardiovascular diseases, as hypertension and coronary heart disease, are linked to adipose tissue physiology and are highly influenced by gender [34,35]. In addition, the use of complementary treatments such as herbal remedies [36,37] and synthetic products [38,39] have been considered to have huge potential as an information source and starting point for the development of antiobesity products. oxaziridines, heterocyclic compounds containing oxygen, nitrogen and carbon atoms in a three-membered ring, were first reported in the mid-fifties by Emmons [40].…”

Protective Effect of Gomisin N against Endoplasmic Reticulum Stress-Induced Hepatic Steatosis

“…Several studies have demonstrated the diverse pharmacological activities of S. chinensis, which include anti-oxidant, anti-tumor, anti-obesity, anti-inflammatory, and cardioprotective effects. [11][12][13][14][15] In addition, hepatoprotective activities of S. chinensis have also been reported. [16][17][18][19] A recent study of ours showed that S. chinensis has a protective effect against ER stress-induced hepatic steatosis (unpublished data).…”