Anti-obesity effect of total phenylpropanoid glycosides from Ligustrum robustum Blume in fatty diet-fed mice via up-regulating leptin

Yang, Ruijie; Liu, Fang; He, Zhendan; Ji, Min Gun; Chu, Xin-xin; Kang, Zhuo-ying; Cai, Daozhang; Nannan, Gao

doi:10.1016/j.jep.2014.12.066

Cited by 31 publications

(23 citation statements)

References 25 publications

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“…This is consistent with that experienced by Yang et al. () in mice fed with a high‐fat diet, whose feed was supplemented with phenylpropanoid glycosides, extracted from the leaves of Ligustrum robustum Blume, a plant used in Chinese folk medicine for the treatment of obesity and hyperlipidemia. These authors have shown that the plant extract produces an inhibition of the synthesis of triglycerides by reducing the expression of RNA messenger, which carries the acetyl transferase diglyceride.…”

Section: Discussionsupporting

confidence: 91%

Dietary effect of lemon verbena extract on selected blood parameters and on plasma oxidative profile in Avelignese horses

Palazzo

Vizzarri

Cinone

et al. 2018

Animal Science Journal

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The effect of Lippia citriodora extract on selected blood parameters and on plasma oxidative markers in Avelignese horses was evaluated. Twenty-four horses were divided into three groups, consisting of eight animals each. Results of two experimental groups, 0.5 mg of verbascoside per kg of metabolic body weight (bw 0.75 ) in the low-dose group (LVB) and 1.0 mg of verbascoside per kg of metabolic body weight (bw 0.75 ) in the high-dose group (HVB), were compared to the control group (CON). Groups fed L. citriodora extract (HVB and LVB) showed a significant decrease in triglycerides, total cholesterol and LDL cholesterol (p < .01), bilirubin, and transaminases (p < .05), and an increase in HDL cholesterol (p < .01) compared to the CON group. Oxidative status was improved due to significant decrease in plasma concentration of ROMs and TBARS (p < .01) and increase in levels of vitamin A and vitamin E (p < .01). Based on obtained results, it is assumed that dietary supplementation with L. citriodora extract might find a useful application in horse feeding, with positive impact observed in blood parameters and plasma oxidative markers, with beneficial effects on the physiological welfare of livestock animals. K E Y W O R D Sanimal welfare, foal, Lippia citriodora, physiology, supplement

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Section: Discussionsupporting

confidence: 91%

Dietary effect of lemon verbena extract on selected blood parameters and on plasma oxidative profile in Avelignese horses

Palazzo

Vizzarri

Cinone

et al. 2018

Animal Science Journal

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“…Acteoside and isoacteoside exist widely in herbal medicines and exhibit multiple beneficial effects against metabolic disorders based on hepatoprotection and inhibition of angiotensin-converting enzyme and α-glucosidase activities [ 34 , 37 , 38 ]. Previous studies report the herb extracts rich in phenylpropanoid glycosides have anti-obesity effects on diet-induced mice, and the possible mechanisms were demonstrated as stimulating leptin expression and cholesterol catabolism, suppressing fatty acid synthesis, and accelerating fatty acid β-oxidation [ 39 , 40 ]. Plantagoguanidinic acid A is a newly found guanidine derivative from P. asiatica L. seeds, and improves glucose metabolism in alloxan-induced diabetic mice [ 29 , 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

Plantago asiatica L. Seed Extract Improves Lipid Accumulation and Hyperglycemia in High-Fat Diet-Induced Obese Mice

Yang

Tong

et al. 2017

IJMS

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Obesity and its common association with type 2 diabetes, dyslipidemia, and cardiovascular diseases are worldwide epidemics. Currently, to prevent or treat obesity and associated metabolic disorders, herbal dietary supplements or medicines have attracted more and more attention owing to their relative effectiveness with fewer significant side effects. We investigate the therapeutic effects and underlying mechanisms of Plantago asiatica L. seed extract (PSE) on obesity and associated metabolic disorders in high-fat (HF) diet-induced mice. Our results displayed that PSE did not modify food intake or body weight but decreased abdominal white adipose tissue ratio, white/brown adipocyte size, serum total cholesterol, triglyceride (TG), low density lipoprotein cholesterol, free fatty acid, and hepatic TG concentrations when compared with the HF group. The levels of fasting blood glucose and glucose tolerance were improved in the PSE group when compared with the HF group. Furthermore, PSE upregulated mRNA expressions of peroxisome proliferator activated receptors (PPARs) and target genes related to fatty acid metabolism and energy expenditure in liver and adipose tissue of obese mice when compared with the HF group. PSE treatment effectively improved lipid and glucose metabolism in HF diet-induced obese mice. These effects might be attributed to the upregulation of PPAR signaling

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“…163 The antiobesity effect of PhGs from L. purpurascens against fatty diet-fed mice was associated with the upregulating of mRNA and protein levels of adipose leptin. 164 Echinacoside (0.01-10 nmol/l) was reported to boost bone regeneration in MC3T3-E1 cells by enhancing receptor activator of NF-κB ligand (RANKL). 165 Similarly, 12 weeks' daily ig administration of echinacoside (30, 90, and 270 mg/kg/day) to ovariectomized (OVX) rats significantly increased osteoprotegerin (OPG) level and decreased RANKL level.…”

Section: Antidiabetic Activitymentioning

confidence: 99%

Therapeutic potential of phenylethanoid glycosides: A systematic review

Georgiev

Cao

et al. 2020

Medicinal Research Reviews

104

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Phenylethanoid glycosides (PhGs) are generally watersoluble phenolic compounds that occur in many medicinal plants. Until June 2020, more than 572 PhGs have been isolated and identified. PhGs possess antibacterial, anticancer, antidiabetic, anti-inflammatory, antiobesity, antioxidant, antiviral, and neuroprotective properties. Despite these promising benefits, PhGs have failed to fulfill their therapeutic applications due to their poor bioavailability. The attempts to understand their metabolic pathways to improve their bioavailability are investigated. In this review article, we will first summarize the number of PhGs compounds which is not accurate in the literature. The latest

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Anti-obesity effect of total phenylpropanoid glycosides from Ligustrum robustum Blume in fatty diet-fed mice via up-regulating leptin

Cited by 31 publications

References 25 publications

Dietary effect of lemon verbena extract on selected blood parameters and on plasma oxidative profile in Avelignese horses

Dietary effect of lemon verbena extract on selected blood parameters and on plasma oxidative profile in Avelignese horses

Plantago asiatica L. Seed Extract Improves Lipid Accumulation and Hyperglycemia in High-Fat Diet-Induced Obese Mice

Therapeutic potential of phenylethanoid glycosides: A systematic review

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