Anti-Obesity Effects of Salted and Unsalted Doenjang Supplementation in C57BL/6J Mice Fed with High Fat Diet

Abstract

The aim of the present study is to elucidate the anti-obesity effects of Doenjang with and without salt in C57BL/6J mice. For the analysis, a total of forty mice were randomly divided into four groups: normal diet group (ND), high-fat diet group (HD), high-fat diet supplemented with 20% Doenjang group (DJ), high-fat diet supplemented with 20% unsalted Doenjang group (NS). During the study period, food intake and body weight were measured daily and weekly, respectively. The animals were sacrificed after 12 weeks. Body weight gain, epididymal fat pad weight and serum triglyceride levels of DJ group were found to be significantly lower than those of the HD and NS groups. Serum total-cholesterol levels of DJ and NS groups were significantly lower as compared to the HD group. There were significant decreases in plasma insulin and leptin levels in DJ group compared with the HD and NS groups. We did not observe any significant changes in the expression of hepatic lipogenic-related gene PPARγ among the HD, DJ and NS groups. However, ACC expression was found to be significantly decreased in DJ group. Lipolysis-related gene (PPARα and CPT-1) expression was significantly higher in the DJ group as compared to HD and NS groups. In conclusion, the results of this study showed that Doenjang supplementation lowers body weight gain and improves obesity-related parameters.Key words: high fat diet, doenjang, unsalted doenjang, C57BL/6J mice, anti-obesity

Anti-hypertensive effect of Korean fermented soybean paste (Doenjang) through regulation of the renin-angiotensin system (RAS) in male rats fed with high-fat and/or high-salt diet

“…These components in soybeans are responsible for its hypolipidemic and antiobesity effects, through increasing β-oxidation and inhibiting fatty acid synthesis [10,22]. Our previous study showed that doenjang has been lowered bodyweight and improved obesity-related parameters such as insulin, leptin, Pparg, and Acc [15]. The results of the present study also con rmed the antiobesity effect of doenjang evident by the decreased gene expression of leptin, while increased adiponectin levels (Fig.…”

“…[11]. However, excessive sodium intake is generally known to increase the risk of hypertension through hypervolemia, promote heart and kidney disease, and contribute to stroke and gastric cancer [14,15].…”

Okara, a soybean by-product, prevents high fat diet-induced obesity and improves serum lipid profiles in C57BL/6J mice

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Effects of Cladosiphon Okamuranus Dietary Fiber on Cholesterol in High Fat Diet-Fed Rats

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