Anti-Osteoporotic Effects of Commiphora Myrrha and Its Poly-Saccharide via Osteoclastogenesis Inhibition

Hwang, Youn–Hwan; Lee, Ami; Kim, Taesoo; Jang, Seon‐A; Ha, Hyunil

doi:10.3390/plants10050945

Cited by 17 publications

(8 citation statements)

References 39 publications

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“…Studies have disclosed the modern pharmacology of myrrh. Water extracts and polysaccharides of C. myrrha are effective to treat the osteoporosis in postmenopausal women ( Hwang et al, 2021 ). A 10 min sitz-bath of myrrh extract greatly relieved the wound healing of the episiotomy in a clinical trial ( Faraji et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

The current status of old traditional medicine introduced from Persia to China

Shi

Yang²,

Zhou³

et al. 2022

Front. Pharmacol.

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Traditional Chinese medicine (TCM) includes over ten thousand herbal medicines, some of which were introduced from outside countries and territories. The Silk Road enabled the exchange of merchandise such as teas, silks, carpets, and medicines between the East and West of the Eurasia continent. During this time, the ‘Compendium of Materia Medica’ (CMM) was composed by a traditional medicine practitioner, Shizhen Li (1,518–1,593) of the Ming Dynasty. This epoch-making masterpiece collected knowledge of traditional medical materials and treatments in China from the 16th century and before in utmost detail, including the origin where a material was obtained. Of 1892 medical materials from the CMM, 46 came from Persia (now Iran). In this study, the basic information of these 46 materials, including the time of introduction, the medicinal value in TCM theory, together with the current status of these medicines in China and Iran, are summarized. It is found that 20 herbs and four stones out of the 46 materials are registered as medicinal materials in the latest China Pharmacopoeia. Now most of these herbs and stones are distributed in China or replacements are available but saffron, ferula, myrrh, and olibanum are still highly dependent on imports. This study may contribute to the further development, exchange, and internationalization of traditional medicine of various backgrounds in the world, given the barriers of transportation and language are largely eased in nowadays.

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Section: Resultsmentioning

confidence: 99%

The current status of old traditional medicine introduced from Persia to China

Shi

Yang²,

Zhou³

et al. 2022

Front. Pharmacol.

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“…After adaptation for 1 week, animals were randomly divided into 5 groups ( n = 5/group) as naïve, sham, OVX, OVX supplemented 5 mg/kg, and OVX supplemented 10 mg/kg. Under anesthesia using isoflurane (Baxter, Deerfield, IL, USA), the mice were surgically ovariectomized via dorsolateral incisions, as previously described [ 46 ]. In addition, sham was generated by bilateral dorsal laparotomy.…”

Section: Methodsmentioning

confidence: 99%

The Ethanol Extracts of Osmanthus fragrans Leaves Ameliorate the Bone Loss via the Inhibition of Osteoclastogenesis in Osteoporosis

Seo

Lim

Seo

et al. 2023

Plants

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The aim of this study was to evaluate the anti-osteoporosis effects of Osmanthus fragrans leaf ethanol extract (OFLEE) in bone marrow-derived macrophages (BMM) and animals with osteoporosis. OFLEE not only suppressed tartrate-resistant acid phosphatase (TRAP)-positive cells with multiple nuclei but also decreased TRAP activity in BMM treated with macrophage colony stimulating factor (M-CSF) and receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL). The formation of F-actin rings and the expression and activation of matrix metalloproteinases were decreased by OFLEE in BMM treated with M-CSF and RANKL. OFLEE suppressed M-CSF- and RANKL-induced osteoclastogenesis by inhibiting NF-κB phosphorylation, tumor necrosis factor receptor-associated factor 6, c-fos, the nuclear factor of activated T-cells, cytoplasmic 1, and cathepsin K in BMM. OFLEE downregulated reactive oxygen species, cyclooxygenase-2, inducible nitric oxide synthase, prostaglandin E2, tumor necrosis factor α, interleukin (IL)-1β, IL-6, IL-17, and RANKL in BMM treated with M-CSF and RANKL. Oral administration of OFLEE suppressed osteoporotic bone loss without hepatotoxicity in ovariectomy-induced osteoporosis animals. Our findings suggest that OFLEE, with anti-inflammatory effects, prevents osteoporotic bone loss through the suppression of osteoclastic differentiation in BMM and animals with osteoporosis.

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“…8 Various traditional herbal medicines are recognized as safe and cost-effective treatments for musculoskeletal disorders, such as Rhizoma Drynariae, Fructus Psoraleae, Salvia miltiorrhiza, Herba Epimedii, Commiphora myrrha, and Radix Dipsaci. [9][10][11][12][13][14] Taiwanofungus camphoratus, or Antrodia cinnamomea, is a native medicinal mushroom distinguished by its orange-red fruit bodies. This particular fungus only grows inside the native Cinnamomum kanehirae Hayata tree, which belongs to the Lauraceae family.…”

Section: Introductionmentioning

confidence: 99%

“…Traditionally used Chinese medicinal herbs are a valuable source for developing new drugs because they include active ingredients that have the ability to treat a wide range of illnesses 8 . Various traditional herbal medicines are recognized as safe and cost‐effective treatments for musculoskeletal disorders, such as Rhizoma Drynariae , Fructus Psoraleae , Salvia miltiorrhiza , Herba Epimedii , Commiphora myrrha , and Radix Dipsaci 9–14 . Taiwanofungus camphoratus , or Antrodia cinnamomea , is a native medicinal mushroom distinguished by its orange‐red fruit bodies.…”

Section: Introductionmentioning

confidence: 99%

Antrodia cinnamomea prevents ovariectomized‐promoted bone loss by inhibiting osteoclast formation

Po‐Chun,

Su,

Liu

et al. 2024

Environmental Toxicology

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Osteoporosis is a common bone disease in aging populations, particularly in postmenopausal women. Anti‐resorptive and anabolic drugs have been applied to prevent and cure osteoporosis and are linked with a variety of adverse effects. Antrodia cinnamomea extracts (ACE) are highly renowned for their anticancer, antioxidative, and anti‐inflammatory properties. However, whether ACE‐enriched anti‐osteoporosis functions are largely unknown. In a preclinical animal model, we found that ovariectomy significantly decreased bone volume in the ovariectomized (OVX) rats. Administration of ACE antagonized OVX‐induced bone loss. In addition, ACE reversed OVX‐reduced biomechanical properties. The serum osteoclast marker also showed improvement in the ACE‐treated group. In the cellular model, it was indicated that ACE inhibits RANKL‐induced osteoclast formation. Taken together, ACE seems to be a hopeful candidate for the development of novel anti‐osteoporosis treatment.

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Anti-Osteoporotic Effects of Commiphora Myrrha and Its Poly-Saccharide via Osteoclastogenesis Inhibition

Cited by 17 publications

References 39 publications

The current status of old traditional medicine introduced from Persia to China

The current status of old traditional medicine introduced from Persia to China

The Ethanol Extracts of Osmanthus fragrans Leaves Ameliorate the Bone Loss via the Inhibition of Osteoclastogenesis in Osteoporosis

Antrodia cinnamomea prevents ovariectomized‐promoted bone loss by inhibiting osteoclast formation

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