Anti-oxidant Property and Tyrosinase Inhibition Activity of Various Extracts from Plants in Compositae Plants

*Antioxidant activities of traditionally brewed Korean rice wines have recently been reported. The objective of this study was to identify the antioxidant activities of the volatile and non-volatile fractions of three Korean rice wines, and further to identify the active ingredients responsible for the antioxidant properties. Volatile and non-volatile components of three rice wines, Measilju, Kukwhaju and Gugijaju, were separated into seven fractions according to their polarities. Antioxidant activities were determined by an aldehyde-carboxylic acid assay for the volatile fractions and a lipid-malondialdehyde assay for the non-volatile fractions. Volatile constituents of each fraction were identified and quantified using gas chromatography-mass spectrometry. In addition, antioxidant activities of specific authentic chemicals from the volatile fractions of the wines were measured, and the antioxidant properties of the volatile fractions were determined. Identification of volatile compounds potentially showing high antioxidant activities were conducted in each fraction of the three wines. Among the volatile compounds identified from volatile fractions of the wines, benzeneethanol, 2-furanmethanol and 4-ethyl-2methoxyphenol showed the highest antioxidant activities, when added at higher concentrations (~100 μg/g). Identification of antioxidant properties, as well as the specific compounds responsible for these antioxidant properties, could aid Korean rice wine product developers, in terms of strategic planning for sales in the Korean market. Copyright

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“…Undecane, a major component of the aroma extracts in Tagetes erecta (L.). in Compositae plants, has also shown strong antioxidant activity .…”

Section: Resultsmentioning

confidence: 99%

“…In fraction v, 3-pyrrolidinol had the highest concentration; in fraction i, undecane had the highest concentration. Undecane, a (27). Volatile components identified in the extracts of GGJ are listed in Table 3.…”

Section: Major Volatile Compounds With Relatively High Antioxidant Acmentioning

confidence: 99%

Antioxidant activities of volatile and non-volatile fractions of selected traditionally brewed Korean rice wines

et al. 2014

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“…maackii have reported anti-inflammatory, , hepatoprotective, and anti-cancer effects. Additionally, it may have a preventive effect in diabetic complications through inhibition of advanced glycation end-product formation and aldose reductase. , Cirsium species show anti-tyrosinase inhibitory activity as well. , …”

Section: Introductionmentioning

confidence: 99%

Discovery of a Highly Potent Tyrosinase Inhibitor, Luteolin 5-O-β-d-Glucopyranoside, Isolated from Cirsium japonicum var. maackii (Maxim.) Matsum., Korean Thistle: Kinetics and Computational Molecular Docking Simulation

et al. 2018

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In the present study, the natural flavonoid luteolin 5-O-β-d-glucopyranoside isolated from the Korean thistle, Cirsium japonicum var. maackii (Maxim.) Matsum., for the first time, found to be a strong competitive inhibitor against mushroom tyrosinase (IC50 = 2.95 ± 0.11 μM, K i = 3.02 μM for l-tyrosine; IC50 = 8.22 ± 0.18 μM, K i = 11.56 μM for l-3,4-dihydroxyphenyl-alanine), which outperformed luteolin and 5-deoxy luteolin (3′,4′,7-trihydroxyflavone), showing noncompetitive and competitive inhibition only in l-tyrosine, respectively, emphasizing the importance of glycosylation at 5-OH position of luteolin. Furthermore, molecular modeling of luteolin 5-O-β-d-glucopyranoside showed strong H-bond interaction with Arg268 and peroxide ion (Per402) present between the copper ions. Additionally, the luteolin 5-O-β-d-glucopyranoside–tyrosinase complex was stabilized by electrostatic and hydrophobic interactions formed with key catalytic residues; however, in luteolin, these were lacking. Therefore, Cirsium maackii may act as an important anti-tyrosinase remedy because of the amount and potency of the active compounds luteolin 5-O-β-d-glucopyranoside and luteolin.

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“…이 과정에서 발생하는 산소는 유기호흡을 하는 생물에 있어 필수적이지만 에너지 대사과정 중 불완전한 환원에 의 해 발생하는 활성 산소종(reactive oxygen species, ROS)은 세포막 지질을 과산화 시키고 생체 내에서 DNA를 손상시켜 암을 유발할 뿐만 아니라 세포노화, 세포막분해, 지방산화 등 심각한 생리적 장애를 초래한다 (18)(19)(20). 이러한 이유에서 방어체계와 관련하여 인간의 노화억제라는 관점에서 연구 되어 오던 항산화제 연구는 합성 항산화제의 독성과 같은 안전성 문제와 천연 항산화물의 약한 활성이 지적되면서 약 용식물로부터 활성물질을 찾는 연구가 활발히 진행되고 있 다 (20,21). 우리나라에 자생하는 약용식물은 약 900여종에 달하며 생약으로 사용할 경우보다 식물 내 활성화합물을 탐 색하여 신물질로 개발하게 된다면 천연물의 경제적 이용가 치는 더욱 높아질 것으로 기대된다 (21).…”

unclassified

“…이러한 이유에서 방어체계와 관련하여 인간의 노화억제라는 관점에서 연구 되어 오던 항산화제 연구는 합성 항산화제의 독성과 같은 안전성 문제와 천연 항산화물의 약한 활성이 지적되면서 약 용식물로부터 활성물질을 찾는 연구가 활발히 진행되고 있 다 (20,21). 우리나라에 자생하는 약용식물은 약 900여종에 달하며 생약으로 사용할 경우보다 식물 내 활성화합물을 탐 색하여 신물질로 개발하게 된다면 천연물의 경제적 이용가 치는 더욱 높아질 것으로 기대된다 (21).…”

unclassified

Effect of Natural Plant Mixtures on Behavioral Profiles and Antioxidants Status in SD Rats

서보영¹,

김민정²,

김현수³

et al. 2011

Journal of the Korean Society of Food Science and Nutrition

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Caffeine, a psychoactive stimulant, has been implicated in the modulation of learning and memory functions due to its action as a non-selective adenosine receptors antagonist. On the contrary, some side effects of caffeine have been reported, such as an increased energy loss and metabolic rate, decrease DNA synthesis in the spleen, and increased oxidative damage to exerted on LDL particles. Therefore, the aim of this study was to develop a safe stimulant from natural plants mixture (Aralia elata, Acori graminei Rhizoma, Chrysanthemum, Dandleion, Guarana, Shepherd's purse) that can be used as a substitute for caffeine. Thirty SD rats were divided into three groups; control group, caffeine group (15.0 mg/kg, i.p.), and natural plants mixture group (NP, 1 mL/kg, p.o.). The effect of NP extract on stimulant activity was evaluated with open-field test (OFT) and plus maze test for measurement of behavioral profiles. Plasma lipid profiles, lipid peroxidation in LDL (conjugated dienes), total antioxidant capacity (TRAP) and DNA damage in white blood, liver, and brain cells were measured. In the OFT, immobility time was increased significantly by acute (once) and chronic (3 weeks) supplementation of NP and showed a similar effect to caffeine treatment. Three weeks of caffeine treatment caused plasma lipid peroxidation and DNA damage in liver cells, whereas there were no changes in the NP group. NP group showed a higher plasma HDL cholesterol concentration compared to the caffeine group. The results indicate that the natural plants mixture had a stimulant effect without inducing oxidative stress.

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Anti-oxidant Property and Tyrosinase Inhibition Activity of Various Extracts from Plants in Compositae Plants

Cited by 14 publications

References 7 publications

Antioxidant activities of volatile and non-volatile fractions of selected traditionally brewed Korean rice wines

Antioxidant activities of volatile and non-volatile fractions of selected traditionally brewed Korean rice wines

Discovery of a Highly Potent Tyrosinase Inhibitor, Luteolin 5-O-β-d-Glucopyranoside, Isolated from Cirsium japonicum var. maackii (Maxim.) Matsum., Korean Thistle: Kinetics and Computational Molecular Docking Simulation

Effect of Natural Plant Mixtures on Behavioral Profiles and Antioxidants Status in SD Rats

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