Anti-oxidative effects of curcumin on immobilization-induced oxidative stress in rat brain, liver and kidney

Samarghandian, Saeed; Azimi‐Nezhad, Mohsen; Farkhondeh, Tahereh; Samini, Fariborz

doi:10.1016/j.biopha.2016.12.105

Cited by 250 publications

(140 citation statements)

References 45 publications

Supporting

Mentioning

124

Contrasting

Unclassified

Order By: Relevance

“…Among the many types of tissues in the body, the brain is more susceptible to stress because of its high levels of intracellular mediators that are involved in the stress response (glucocorticoid receptors) [2]. Stress may induce a variety of central nervous system abnormalities, including depression, anxiety, locomotor activity, and cognitive function [3]. The main mechanism(s) associated with stress-induced behavioral disorders is the activation of the hypothalamo-hypophyseal-adrenal (HPA) axis, which involves elevation of the brain corticosterone level [4].…”

Section: Introductionmentioning

confidence: 99%

Protective effects of carnosol against oxidative stress induced brain damage by chronic stress in rats

Samarghandian

Azimi‐Nezhad

Borji

et al. 2017

BMC Complement Altern Med

Self Cite

View full text Add to dashboard Cite

BackgroundOxidative stress through chronic stress destroys the brain function. There are many documents have shown that carnosol may have a therapeutic effect versus free radical induced diseases. The current research focused the protective effect of carnosol against the brain injury induced by the restraint stress.MethodsThe restraint stress induced by keeping animals in restrainers for 21 consecutive days. Thereafter, the rats were injected carnosol or vehicle for 21 consecutive days. At the end of experiment, all the rats were subjected to his open field test and forced swimming test. Afterwards, the rats were sacrificed for measuring their oxidative stress parameters. To measure the modifications in the biochemical aspects after the experiment, the activities of malondialdehyde (MDA), reduced glutathione (GSH), as well as superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) and catalase (CAT) were evaluated in the whole brain.ResultsOur data showed that the animals received chronic stress had a raised immobility time versus the non-stressed animals (p < 0.01). Furthermore, chronic stress diminished the number of crossing in the animals that were subjected to the chronic stress versus the non-stressed rats (p < 0.01). Carnosol ameliorated this alteration versus the non-treated rats (p < 0.05). In the vehicle treated rats that submitted to the stress, the level of MDA levels was significantly increased (P < 0.001), and the levels of GSH and antioxidant enzymes were significantly decreased versus the non-stressed animals (P < 0.001). Carnosol treatment reduced the modifications in the stressed animals as compared with the control groups (P < 0.001). All of these carnosol effects were nearly similar to those observed with fluoxetine.ConclusionThe current research shows that the protective effects of carnosol may be accompanied with enhanced antioxidant defenses and decreased oxidative injury.

show abstract

Section: Introductionmentioning

confidence: 99%

Protective effects of carnosol against oxidative stress induced brain damage by chronic stress in rats

Samarghandian

Azimi‐Nezhad

Borji

et al. 2017

BMC Complement Altern Med

Self Cite

View full text Add to dashboard Cite

show abstract

“…Based on the use of N. sativa in traditional medicine as a natural treatment for some diseases, researchers have investigated its protective effects against asthma [6], hypertension [7], diabetes [8], and inflammation [9]. In addition, TQ is known to have antioxidant [10], analgesic, antipyretic [11], antischistosomal [12], antifungal [13], antibacterial [14], anticancer [15], anticonvulsant [16], hepatoprotective [17], and neuroprotective activities [18]. It has been found that TQ has beneficial protective effects against renal diseases through anti-inflammatory, antioxidant, and antiapoptotic activities [19].…”

Section: Introductionmentioning

confidence: 99%

An Overview on Renoprotective Effects of Thymoquinone

et al. 2018

Self Cite

View full text Add to dashboard Cite

Background: Kidneys as vital organs remove waste material from blood. Additionally, they may also have a role in the electrolyte balance, regulation of blood pressure, and red blood cell genesis. Kidney diseases may be caused by several factors such as ischemia/reperfusion injury, diabetes, and nephrotoxic agents. Oxidative stress and inflammation are involved in the pathogenesis and progression of kidney diseases. Traditionally, natural antioxidants are used for treatment of renal failure in various countries. Summary: People usually select natural antioxidants since they have an opinion that herbal medicine has not any important side effects. Nigella sativa is a flavoring herb that is widely used as a condiment and as a remedy for many disorders. Thymoquinone (TQ), the most important component of black seeds, mainly oil, is considered as an active agent responsible for a lot of the seed’s useful effects. This review describes the protective roles and related mechanisms of TQ against renal disorders. The search terms, including TQ, antioxidant, renal ischemia-reperfusion, diabetic nephropathy, and nephrotoxic agent were searched in scientific databases. TQ showed anti-inflammatory and antioxidant properties in animal and in vitro models of several renal diseases caused by inflammation and oxidative stress. Key Messages: Experimental studies have shown beneficial effects of TQ against renal diseases; however, well-designed clinical trials in humans are required to confirm these effects.

show abstract

“…As supported by evidence, curcumin prevents the brain stress induced by oxidative damage by increasing the GSH levels and the activity of the superoxide dismutase (SOD), GSH-peroxidase (GPx), GSH-reductase (GR) and catalase (CAT) antioxidant enzymes [90]. The anti-inflammatory property of curcumin manifests itself by increasing the levels of anti-inflammatory cytokines as well as the expression of the NF-κB transcription factor [91]. Although curcumin promotes the aforementioned activities and has strong neuroprotective compound, its use is limited by its poor absorption, rapid metabolism with systemic excretion and a limited permeability at the BBB level [92].…”

Section: Turmericmentioning

confidence: 95%

The Potential for Natural Antioxidant Supplementation in the Early Stages of Neurodegenerative Disorders

Oppedisano

Maiuolo

Gliozzi

et al. 2020

IJMS

View full text Add to dashboard Cite

The neurodegenerative process is characterized by the progressive ultrastructural alterations of selected classes of neurons accompanied by imbalanced cellular homeostasis, a process which culminates, in the later stages, in cell death and the loss of specific neurological functions. Apart from the neuronal cell impairment in selected areas of the central nervous system which characterizes many neurodegenerative diseases (e.g., Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Disease, etc.), some alterations may be found in the early stages including gliosis and the misfolding or unfolding accumulation of proteins. On the other hand, several common pathophysiological mechanisms can be found early in the course of the disease including altered oxidative metabolism, the loss of cross-talk among the cellular organelles and increased neuroinflammation. Thus, antioxidant compounds have been suggested, in recent years, as a potential strategy for preventing or counteracting neuronal cell death and nutraceutical supplementation has been studied in approaching the early phases of neurodegenerative diseases. The present review will deal with the pathophysiological mechanisms underlying the early stages of the neurodegenerative process. In addition, the potential of nutraceutical supplementation in counteracting these diseases will be assessed.

show abstract

Anti-oxidative effects of curcumin on immobilization-induced oxidative stress in rat brain, liver and kidney

Cited by 250 publications

References 45 publications

Protective effects of carnosol against oxidative stress induced brain damage by chronic stress in rats

Protective effects of carnosol against oxidative stress induced brain damage by chronic stress in rats

An Overview on Renoprotective Effects of Thymoquinone

The Potential for Natural Antioxidant Supplementation in the Early Stages of Neurodegenerative Disorders

Contact Info

Product

Resources

About